Journal
EMERGING INFECTIOUS DISEASES
Volume 28, Issue 9, Pages 1920-1923Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2809.220875
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Funding
- European Union's Horizon 2020 research and innovation program [874735, 101003589]
- ZonMW [10150062010005]
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This study reports the detection of a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised patient several months after the latest detection of the Alpha variant in the Netherlands. The patient remained infected for 42 weeks despite multiple treatment regimens and the disappearance of most clinical symptoms. Several potential immune escape mutations were identified in the spike protein.
We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.
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