Journal
TALANTA OPEN
Volume 6, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talo.2022.100161
Keywords
Carbon dots; Aptamer; Photodynamic therapy; Photosensitizer; Fluorescence; Cancer cells
Categories
Funding
- National Natural Science Foundations of China [52172033, 51772001, 22005280]
- Anhui Province Key Research and Development Plan Project International Science and Technology Cooperation Special Project [202004b11020015]
- National Key R&D Program of China [2021YFA1600202]
- Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education
- Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, China
- Key Laboratory of Environment-Friendly Polymer Materials of Anhui Province
- Anhui Key Laboratory of Modern Biomanufacturing, Anhui University, China
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This study chemically modified AS1411 aptamer onto the surface of Asp-CDs, creating Asp-CDs@AS1411 with specific recognition and significantly enhanced phototoxicity to tumor cells. This strategy provides a new approach for developing high-performance materials for photodynamic therapy.
Carbon dots (CDs) have emerged as promising materials for photodynamic therapy (PDT) because of their intriguing photochemical properties, high stability, and low toxicity. However, achieving accurate delivery of CDs based photosensitizers into tumor sites remains a grand challenge. Herein, AS1411 aptamer, a short oligonucleotide sequence with high binding specificity to tumor cells, was chemically decorated to the surface of Asp-CDs to obtain Asp-CDs@AS1411. The aptamer modified Asp-CDs@AS1411 not only retains the excellent properties of Asp-CDs such as high singlet oxygen quantum yield (up to 50%), bright photoluminescence, and good stability, but also features specific recognition and markedly enhanced phototoxicity (4 times) to tumor cells. These combined attributes make Asp-CDs@AS1411 a promising PDT agent for efficient tumor treatment. More importantly, the reported strategy paves a new avenue for developing high performance PDT materials from surface functionalized CDs featuring high photosensitivity and targeting ability.
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