Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 90, Pages 12560-12563Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc04905h
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This paper reports a chemoselective approach to catch and enrich amine-containing natural products, releasing them as underivatized compounds.
Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the specific release of amine-containing natural products.
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