Journal
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 129, Issue 1, Pages 26-32Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2020.1792505
Keywords
COVID-19; vitamin D; ACE2; diabetes; cardiovascular disease
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The risk of severe complications in COVID-19 patients is higher in individuals with low levels of vitamin D. Vitamin D supplementation may enhance the immune system and reduce the severity of the disease.
Coronavirus disease (COVID-19) is an infectious disease caused by a new virus that causes respiratory illness. Older adults and individuals who have pre-existing chronic medical conditions are at higher risk for more serious complications from COVID-19. Hypovitaminosis D is attributed to the increased risk of lung injury and acute respiratory distress syndrome (ARDS) as well as diabetes, cardiovascular events and associated comorbidities, which are the main causes of severe clinical complications in COVID-19 patients. Considering the defensive role of vitamin D, mediated through modulation of the innate and adaptive immune system as well as inhibition of the Renin Angiotensin System (RAS), vitamin D supplementation might boost the immune system of COVID-19 patients and reduce severity of the disease in vitamin D deficient individuals.
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