Journal
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 129, Issue 2, Pages 439-448Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2020.1835985
Keywords
Exercise; irisin; neurodegeneration; neuropathic pain; calcium
Ask authors/readers for more resources
This study aimed to investigate the role of irisin in the neuroprotective process of exercise training in diabetic rats. It was found that irisin may have a role in the neuroprotective effect of exercise training.
We aimed to investigate the contribution of irisin in the neuroprotective process of exercise training in diabetic rats. Serum irisin levels, thermal and mechanical pain thresholds and intracellular calcium ([Ca2+](i)) levels in sensory neurons were measured at different time intervals during the eight weeks of exercise sessions for the control, non-exercise diabetics (3 groups) and exercise performing (low and high intensity groups) diabetic rats (n = 7-10 for all groups). Non-exercise diabetic groups were treated with irisin in different doses (1, 10 and 20 mu g/kg respectively). Recovered pain thresholds at the end of the exercise sessions (p < .05), higher serum irisin levels that compared to control and diabetics (p < .05) and insignificant mean [Ca2(+)](i) peak amplitudes in sensory neurons (p > .05) obtained from experiments. Furthermore, irisin injection decreased the thermal pain threshold of diabetics only at 60th minutes (p < .05). Irisin may have a role in the neuroprotective effect of exercise training.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available