Related references
Note: Only part of the references are listed.Genetic variation in endocannabinoid signaling is associated with differential network-level functional connectivity in youth
Lucinda M. Sisk et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2022)
Fatty acid amide hydrolase is lower in young cannabis users
Maya R. Jacobson et al.
ADDICTION BIOLOGY (2021)
An adaptive randomized clinical trial in interstitial cystitis/bladder pain syndrome evaluating efficacy of ASP3652 and the relationship between disease characteristics and Hunner's lesions
Jos G. A. Houbiers et al.
WORLD JOURNAL OF UROLOGY (2021)
The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study
Mark E. Schmidt et al.
NEUROPSYCHOPHARMACOLOGY (2021)
Association of the Fatty Acid Amide Hydrolase C385A Polymorphism With Alcohol Use Severity and Coping Motives in Heavy-Drinking Youth
Laura M. Best et al.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2021)
CB2 Receptor in Microglia: The Guardian of Self-Control
Joanna Agnieszka Komorowska-Mueller et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial
Martin P. Paulus et al.
NEUROPSYCHOPHARMACOLOGY (2021)
Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase
Haley A. Vecchiarelli et al.
NEUROPSYCHOPHARMACOLOGY (2021)
Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study
Nathan J. Kolla et al.
TRANSLATIONAL PSYCHIATRY (2021)
Does irritable bowel syndrome increase the risk of interstitial cystitis/bladder pain syndrome? A cohort study of long term follow-up
Kun-Min Chang et al.
INTERNATIONAL UROGYNECOLOGY JOURNAL (2021)
Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals
Duncan G. J. Green et al.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE (2021)
Fear extinction learning and anandamide: an fMRI study in healthy humans
Jennifer Spohrs et al.
TRANSLATIONAL PSYCHIATRY (2021)
Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice
Leah M. Mayo et al.
MOLECULAR PSYCHIATRY (2020)
Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial
Leah M. Mayo et al.
BIOLOGICAL PSYCHIATRY (2020)
Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats
Ana Charrua et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)
D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction
Esmaeil Mansouri et al.
NEUROPSYCHOPHARMACOLOGY (2020)
FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence
Wei Zhang et al.
ANNALS OF HUMAN GENETICS (2020)
Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB
Laura M. Best et al.
NEUROPSYCHOPHARMACOLOGY (2020)
Regions of the brain activated in bladder filling vs rectal distention in healthy adults: A meta-analysis of neuroimaging studies
Priyanka Kadam Halani et al.
NEUROUROLOGY AND URODYNAMICS (2020)
Imaging Brain Fatty Acid Amide Hydrolase in Untreated Patients With Psychosis
Jeremy J. Watts et al.
BIOLOGICAL PSYCHIATRY (2020)
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP3652, a Reversible Fatty Acid Amide Hydrolase Inhibitor, in Healthy, Nonelderly, Japanese Men and Elderly, Japanese Men and Women: A Randomized, Double-blind, Placebo-controlled, Single and Multiple Oral Dose, Phase I Study
Masaomi Takizawa et al.
CLINICAL THERAPEUTICS (2020)
ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain
Tetsuo Kiso et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2020)
Development of an In Vivo Method to Estimate Effective Drug Doses and Quantify Fatty Acid Amide Hydrolase in Rodent Brain using Positron Emission Tomography Tracer [11C]DFMC
Tomoteru Yamasaki et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2020)
From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases
Eddie Cano-Gamez et al.
FRONTIERS IN GENETICS (2020)
Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [11C]CURB positron emission tomography study
N. J. Kolla et al.
NEUROPSYCHOPHARMACOLOGY (2020)
Resting state functional connectivity of the pain matrix and default mode network in irritable bowel syndrome: a graph theoretical analysis
Michiko Kano et al.
SCIENTIFIC REPORTS (2020)
Synthesis and preliminary evaluation of a novel positron emission tomography (PET) ligand for imaging fatty acid amide hydrolase (FAAH)
Zhen Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)
Multimodal Neuroimaging: Basic Concepts and Classification of Neuropsychiatric Diseases
Emine Elif Tulay et al.
CLINICAL EEG AND NEUROSCIENCE (2019)
Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity
Abdella M. Habib et al.
BRITISH JOURNAL OF ANAESTHESIA (2019)
Opportunities and challenges for transcriptome-wide association studies
Michael Wainberg et al.
NATURE GENETICS (2019)
A Cocktail Interaction Study Evaluating the Drug-Drug Interaction Potential of the Perpetrator Drug ASP8477 at Multiple Ascending Dose Levels
Nicoline Treijtel et al.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT (2019)
The influence of the brain-gut axis in inflammatory bowel disease and possible implications for treatment
Dowd J. Gracie et al.
LANCET GASTROENTEROLOGY & HEPATOLOGY (2019)
Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
Wen Zhang et al.
NATURE COMMUNICATIONS (2019)
Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene
Mariangela Pucci et al.
INTERNATIONAL JOURNAL OF EATING DISORDERS (2019)
Clinical epigenetics: seizing opportunities for translation
Maria Berdasco et al.
NATURE REVIEWS GENETICS (2019)
Activation of Peripheral Blood CD4+T-Cells in IBS is not Associated with Gastrointestinal or Psychological Symptoms
Yasmin Nasser et al.
SCIENTIFIC REPORTS (2019)
A Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Phase I Study of Analgesic/Antihyperalgesic Properties of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Healthy Female Subjects
Klaus Schaffler et al.
PAIN MEDICINE (2018)
Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers
Andrey Postnov et al.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2018)
Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance
Georgia Balsevich et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
Alvaro N. Barbeira et al.
NATURE COMMUNICATIONS (2018)
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
Tanbeena Imam et al.
FRONTIERS IN IMMUNOLOGY (2018)
Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history
Sara Anna Bonini et al.
JOURNAL OF ETHNOPHARMACOLOGY (2018)
The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents
Guy Griebel et al.
SCIENTIFIC REPORTS (2018)
Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats
Min Jee Kim et al.
MOLECULAR PAIN (2018)
Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant
Matthew E. Sloan et al.
ADDICTION BIOLOGY (2018)
The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations
Stefania Petrosino et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor
Tomonari Watabiki et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2017)
ASSESSMENT OF INTRA- AND INTER-REGIONAL INTERRELATIONS BETWEEN GABA plus , GLX AND BOLD DURING PAIN PERCEPTION IN THE HUMAN BRAIN - A COMBINED 1H FMRS AND FMRI STUDY
Marianne Cleve et al.
NEUROSCIENCE (2017)
The MOBILE Study-A Phase IIa Enriched Enrollment Randomized Withdrawal Trial to Assess the Analgesic Efficacy and Safety of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Patients with Peripheral Neuropathic Pain
Daniel Bradford et al.
PAIN MEDICINE (2017)
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Annelot C. M. van Esbroeck et al.
SCIENCE (2017)
Fatty Acid Amide Hydrolase Inhibitor Treatment in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: An Adaptive Double-blind, Randomized Controlled Trial
Florian M. E. Wagenlehner et al.
UROLOGY (2017)
Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation
Haidar Shamran et al.
BRAIN BEHAVIOR AND IMMUNITY (2017)
Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([11C]MPPO) Based on α-Ketoheterocyclic Scaffold
Lu Wang et al.
ACS CHEMICAL NEUROSCIENCE (2016)
URB937, a peripherally restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2-induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibres in rats
Naoki Aizawa et al.
BJU INTERNATIONAL (2016)
Neurobiological Interactions Between Stress and the Endocannabinoid System
Maria Morena et al.
NEUROPSYCHOPHARMACOLOGY (2016)
Abnormal functional connectivity in women with urgency urinary incontinence: Can we predict disease presence and severity in individual women using Rs-fcMRI/
Rahel Nardos et al.
NEUROUROLOGY AND URODYNAMICS (2016)
Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats
Claudius Fuellhase et al.
NEUROUROLOGY AND URODYNAMICS (2016)
Involvement of Endocannabinoids in Alcohol Binge Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists
Yan Zhou et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2016)
FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence
Primavera A. Spagnolo et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2016)
Abnormal Amygdala Resting-State Functional Connectivity in Irritable Bowel Syndrome
R. Qi et al.
AMERICAN JOURNAL OF NEURORADIOLOGY (2016)
Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [11C] CURB
Isabelle Boileau et al.
BIOLOGICAL PSYCHIATRY (2016)
The Impact of Exposure to Cannabinoids in Adolescence: Insights From Animal Models
Tiziana Rubino et al.
BIOLOGICAL PSYCHIATRY (2016)
N-(3,4-Dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[11C]methylphenyl)thiazol-2-yl]-1-carboxamide: A promising positron emission tomography ligand for fatty acid amide hydrolase
Yoko Shimoda et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans
Whitney E. Melroy-Greif et al.
DRUG AND ALCOHOL DEPENDENCE (2016)
FAAH inhibitors in the limelight, but regrettably
Christophe Mallet et al.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS (2016)
Liposome Based Intravesical Therapy Targeting Nerve Growth Factor Ameliorates Bladder Hypersensitivity in Rats with Experimental Colitis
Naoki Kawamorita et al.
JOURNAL OF UROLOGY (2016)
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
Zhihong Zhu et al.
NATURE GENETICS (2016)
Integrative approaches for large-scale transcriptome-wide association studies
Alexander Gusev et al.
NATURE GENETICS (2016)
Identifying Multimodal Intermediate Phenotypes Between Genetic Risk Factors and Disease Status in Alzheimer's Disease
Xiaoke Hao et al.
NEUROINFORMATICS (2016)
Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase
Anne Kerbrat et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species
Dylan G. Gee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Safety, Tolerability and Pharmacokinetics of FAAH Inhibitor V158866: A Double-Blind, Randomised, Placebo-Controlled Phase I Study in Healthy Volunteers
Stephen Pawsey et al.
DRUGS IN R&D (2016)
Cannabis Use and Risk of Psychiatric Disorders Prospective Evidence From a US National Longitudinal Study
Carlos Blanco et al.
JAMA PSYCHIATRY (2016)
The relationship between irritable bowel syndrome, functional dyspepsia, chronic fatigue and overactive bladder syndrome: a controlled study 6 years after acute gastrointestinal infection
Robert Persson et al.
BMC GASTROENTEROLOGY (2015)
Genome-wide association data classification and SNPs selection using two-stage quality-based Random Forests
Thanh-Tung Nguyen et al.
BMC GENOMICS (2015)
Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [11C]CURB
Isabelle Boileau et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)
The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB
Isabelle Boileau et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)
Corticotropin-Releasing Hormone Drives Anandamide Hydrolysis in the Amygdala to Promote Anxiety
J. Megan Gray et al.
JOURNAL OF NEUROSCIENCE (2015)
A gene-based association method for mapping traits using reference transcriptome data
Eric R. Gamazon et al.
NATURE GENETICS (2015)
Endocannabinoid signalling and the deteriorating brain
Vincenzo Di Marzo et al.
NATURE REVIEWS NEUROSCIENCE (2015)
Interoceptive predictions in the brain
Lisa Feldman Barrett et al.
NATURE REVIEWS NEUROSCIENCE (2015)
Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms
Sandra Sirrs et al.
ORPHANET JOURNAL OF RARE DISEASES (2015)
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279
John M. Keith et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Rare coding variants and X-linked loci associated with age at menarche
Kathryn L. Lunetta et al.
NATURE COMMUNICATIONS (2015)
FAAH genetic variation enhances fronto-amygdala function in mouse and human
Iva Dincheva et al.
NATURE COMMUNICATIONS (2015)
Development of [11C]MFTC for PET Imaging of Fatty Acid Amide Hydrolase in Rat and Monkey Brains
Katsushi Kumata et al.
ACS CHEMICAL NEUROSCIENCE (2015)
Attenuation of Cystitis and Pain Sensation in Mice Lacking Fatty Acid Amide Hydrolase
Zun-Yi Wang et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2015)
Synthesis and Preclinical Evaluation of [18F]FCHC for Neuroimaging of Fatty Acid Amide Hydrolase
Timothy M. Shoup et al.
MOLECULAR IMAGING AND BIOLOGY (2015)
Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture
Cyro Jose de Moraes Martins et al.
PLOS ONE (2015)
Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress
Gaurav Bedse et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2014)
Loss-of-Function Mutations in PNPLA6 Encoding Neuropathy Target Esterase Underlie Pubertal Failure and Neurological Deficits in Gordon Holmes Syndrome
A. Kemal Topaloglu et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH)
M. Salaga et al.
JOURNAL OF CROHNS & COLITIS (2014)
Decreased enteric fatty acid amide hydrolase activity is associated with colonic inertia in slow transit constipation
Shu-Cheng Zhang et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)
Association of cannabinoid type 1 receptor and fatty acid amide hydrolase genetic polymorphisms in Chinese patients with irritable bowel syndrome
Yingjie Jiang et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)
Whole-Body Radiation Dosimetry of C-11-Carbonyl-URB694: A PET Tracer for Fatty Acid Amide Hydrolase
Isabelle Boileau et al.
JOURNAL OF NUCLEAR MEDICINE (2014)
Inhibition of Peripheral FAAH Depresses Activities of Bladder Mechanosensitive Nerve Fibers of the Rat
Naoki Aizawa et al.
JOURNAL OF UROLOGY (2014)
Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures
Kora-Mareen Buehler et al.
MOLECULAR GENETICS AND GENOMICS (2014)
PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Nonhuman Primates
Benjamin H. Rotstein et al.
MOLECULAR PHARMACEUTICS (2014)
The Fatty Acid Amide Hydrolase Inhibitor Oleoyl Ethyl Amide Counteracts Bladder Overactivity in Female Rats
Giorgio Gandaglia et al.
NEUROUROLOGY AND URODYNAMICS (2014)
Association of the c. 385C>A (p. Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population
Tetsuya Ando et al.
MOLECULAR GENETICS & GENOMIC MEDICINE (2014)
Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase
Oleg Sadovski et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Metabolism of endocannabinoids and related N-acylethanolamines: Canonical and alternative pathways
Natsuo Ueda et al.
FEBS JOURNAL (2013)
Systematic review of the relationship between bladder and bowel function: implications for patient management
S. A. Kaplan et al.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2013)
Distribution and function of the endocannabinoid system in the rat and human bladder
Evangelia Bakali et al.
INTERNATIONAL UROGYNECOLOGY JOURNAL (2013)
Mapping human brain fatty acid amide hydrolase activity with PET
Pablo M. Rusjan et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)
Radiosynthesis and Evaluation of [11C-Carbonyl]-Labeled Carbamates as Fatty Acid Amide Hydrolase Radiotracers for Positron Emission Tomography
Alan A. Wilson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Spinal Cord FAAH in Normal Micturition Control and Bladder Overactivity in Awake Rats
Claudius Fuellhase et al.
JOURNAL OF UROLOGY (2013)
Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure
M. N. Hill et al.
MOLECULAR PSYCHIATRY (2013)
Rare Complete Knockouts in Humans: Population Distribution and Significant Role in Autism Spectrum Disorders
Elaine T. Lim et al.
NEURON (2013)
Synthesis and preclinical evaluation of [11C-carbonyl]PF-04457845 for neuroimaging of fatty acid amide hydrolase
Justin W. Hicks et al.
NUCLEAR MEDICINE AND BIOLOGY (2013)
Endocannabinoid and Cannabinoid-Like Fatty Acid Amide Levels Correlate with Pain-Related Symptoms in Patients with IBS-D and IBS-C: A Pilot Study
Jakub Fichna et al.
PLOS ONE (2013)
Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period
Tiffany T-Y Lee et al.
SYNAPSE (2013)
Amygdala FAAH and anandamide: mediating protection and recovery from stress
Ozge Gunduz-Cinar et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase
Ping Liu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
No association of candidate genes with cannabis use in a large sample of Australian twin families
Karin J. H. Verweij et al.
ADDICTION BIOLOGY (2012)
Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex
Leonora E. Long et al.
BMC NEUROSCIENCE (2012)
Positron emission tomography molecular imaging for drug development
Paul M. Matthews et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects
Gai Ling Li et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice
M. Bashashati et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Expression of Fatty Acid Amide Hydrolase (FAAH) in Human, Mouse, and Rat Urinary Bladder and Effects of FAAH Inhibition on Bladder Function in Awake Rats
Frank Strittmatter et al.
EUROPEAN UROLOGY (2012)
Relationship among metabolic syndrome, C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance
D. A. de Luis et al.
JOURNAL OF DIABETES AND ITS COMPLICATIONS (2012)
High frequency of overlap between functional dyspepsia and overactive bladder
J. Matsuzaki et al.
NEUROGASTROENTEROLOGY AND MOTILITY (2012)
Endocannabinoid Signaling and Synaptic Function
Pablo E. Castillo et al.
NEURON (2012)
TIMING IS EVERYTHING: EVIDENCE FOR A ROLE OF CORTICOLIMBIC ENDOCANNABINOIDS IN MODULATING HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVITY ACROSS DEVELOPMENTAL PERIODS
T. T. -Y. Lee et al.
NEUROSCIENCE (2012)
The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)
Marc B. Skaddan et al.
NUCLEAR MEDICINE AND BIOLOGY (2012)
An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee
John P. Huggins et al.
PAIN (2012)
Epigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease
Claudio D'Addario et al.
PLOS ONE (2012)
Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
Matthew T. Maurano et al.
SCIENCE (2012)
385 C/A polymorphism of the fatty acid amide hydrolase gene is associated with metabolic syndrome in the Chinese Han population
LinYang Zeng et al.
ARCHIVES OF MEDICAL SCIENCE (2011)
Brain Type 1 Cannabinoid Receptor Availability in Patients with Anorexia and Bulimia Nervosa
Nathalie Gerard et al.
BIOLOGICAL PSYCHIATRY (2011)
Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation
Fabiola Voznika Merriam et al.
BJU INTERNATIONAL (2011)
Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction
Chuan-Yun Li et al.
BMC GENOMICS (2011)
Synthesis and Application of Isocyanates Radiolabeled with Carbon-11
Alan A. Wilson et al.
CHEMISTRY-A EUROPEAN JOURNAL (2011)
Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients With Nonconstipated Irritable Bowel Syndrome
Banny S. Wong et al.
GASTROENTEROLOGY (2011)
Quantitative Meta-analysis Identifies Brain Regions Activated During Rectal Distension in Irritable Bowel Syndrome
Kirsten Tillisch et al.
GASTROENTEROLOGY (2011)
Approximating Protein Flexibility through Dynamic Pharmacophore Models: Application to Fatty Acid Amide Hydrolase (FAAH)
Anna L. Bowman et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain
Kay Ahn et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease
A. Di Sabatino et al.
MUCOSAL IMMUNOLOGY (2011)
Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss after a hypocaloric diet
Daniel Antonio de Luis et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2011)
[11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography
Alan A. Wilson et al.
NUCLEAR MEDICINE AND BIOLOGY (2011)
Differential Developmental Trajectories for CB1 Cannabinoid Receptor Expression in Limbic/Associative and Sensorimotor Cortical Areas
Lijun Heng et al.
SYNAPSE (2011)
Are Ulcerative and Nonulcerative Interstitial Cystitis/Painful Bladder Syndrome 2 Distinct Diseases? A Study of Coexisting Conditions
Kenneth M. Peters et al.
UROLOGY (2011)
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor
Douglas S. Johnson et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
Epigenetics and lifestyle
Jorge Alejandro Alegra-Torres et al.
EPIGENOMICS (2011)
Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects
Eva M. Marco et al.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2011)
Fine-Scale Survey of X Chromosome Copy Number Variants and Indels Underlying Intellectual Disability
Annabel C. Whibley et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2010)
Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
Timo D. Mueller et al.
BMC MEDICAL GENETICS (2010)
Cannabinoid-Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders
Javier Fernandez-Ruiz et al.
CNS NEUROSCIENCE & THERAPEUTICS (2010)
C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2
D. A. de Luis et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2010)
FAAH deficiency promotes energy storage and enhances the motivation for food
C. Tourino et al.
INTERNATIONAL JOURNAL OF OBESITY (2010)
X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase
Mauro Mileni et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Biomarkers of Endocannabinoid System Activation in Severe Obesity
Jack C. Sipe et al.
PLOS ONE (2010)
Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1
D. Proudnikov et al.
PHARMACOGENOMICS JOURNAL (2010)
The role of the endocannabinoid system in lipogenesis and fatty acid metabolism
Roberto Vettor et al.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Divergent Effects of Genetic Variation in Endocannabinoid Signaling on Human Threat- and Reward-Related Brain Function
Ahmad R. Hariri et al.
BIOLOGICAL PSYCHIATRY (2009)
Radiosynthesis, in vitro and in vivo evaluation of I-123-labeled anandamide analogues for mapping brain FAAH
Leonie Wyffels et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain
Kay Ahn et al.
CHEMISTRY & BIOLOGY (2009)
Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects
P. Monteleone et al.
GENES BRAIN AND BEHAVIOR (2009)
Synthesis, In Vitro and In Vivo Evaluation, and Radiolabeling of Aryl Anandamide Analogues as Candidate Radioligands for In Vivo Imaging of Fatty Acid Amide Hydrolase in the Brain
Leonie Wyffels et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Positron emission tomography neuroimaging for a better understanding of the biology of ADHD
Luc Zimmer
NEUROPHARMACOLOGY (2009)
Suppression of Amygdalar Endocannabinoid Signaling by Stress Contributes to Activation of the Hypothalamic-Pituitary-Adrenal Axis
Matthew N. Hill et al.
NEUROPSYCHOPHARMACOLOGY (2009)
Variants in the CNR1 and the FAAH Genes and Adiposity Traits in the Community
Wolfgang Lieb et al.
OBESITY (2009)
Ulcerative Colitis Induces Changes on the Expression of the Endocannabinoid System in the Human Colonic Tissue
Lucia Marquez et al.
PLOS ONE (2009)
Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent
Yi Zhang et al.
PHARMACOGENOMICS (2009)
The genetic landscape of intellectual disability arising from chromosome X
Jozef Gecz et al.
TRENDS IN GENETICS (2009)
Antecedent Nonbladder Syndromes in Case-Control Study,of Interstitial Cystitis/Painful Bladder Syndrome
John W. Warren et al.
UROLOGY (2009)
Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure
Miriam Schneider
ADDICTION BIOLOGY (2008)
Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation
Michael Camilleri et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Endocannabinoid system in food intake and metabolic regulation
David Jesudason et al.
CURRENT OPINION IN LIPIDOLOGY (2008)
Targeting endocannabinoid degradation protects against experimental colitis in mice:: involvement of CB1 and CB2 receptors
Martin A. Storr et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2008)
Cannabinoid receptors: Where they are and what they do
K. Mackie
JOURNAL OF NEUROENDOCRINOLOGY (2008)
Biological functions and metabolism of oleoylethanolamide
Clementine Thabuis et al.
LIPIDS (2008)
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
Christoph Buettner et al.
NATURE MEDICINE (2008)
Targeting the endocannabinoid system: to enhance or reduce?
Vincenzo Di Marzo
NATURE REVIEWS DRUG DISCOVERY (2008)
Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population
Emmanuelle Durand et al.
OBESITY FACTS (2008)
The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women
Palmiero Monteleone et al.
PSYCHONEUROENDOCRINOLOGY (2008)
Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa
Timo Müller et al.
Child and Adolescent Psychiatry and Mental Health (2008)
Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus
E. Soria-Gomez et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
The expression of receptors for endocannabinoids in human and rodent skeletal muscle
Paul Cavuoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
Jacqueline L. Blankman et al.
CHEMISTRY & BIOLOGY (2007)
Neural mechanisms of pelvic organ cross-sensitization
A. P. Malykhina
NEUROSCIENCE (2007)
Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
Shinya Iwasaki et al.
PSYCHIATRIC GENETICS (2007)
The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: Studies of drug use and dependence in Caucasians
Rachel F. Tyndale et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2007)
The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
Dorit P. Jensen et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2007)
Genetic variation in two proteins of the endocannabinoid system and their influence on body mass index and metabolism under low fat diet
J. Aberle et al.
HORMONE AND METABOLIC RESEARCH (2007)
The endogenous cannabinoid anandamide produces δ-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport
Marcello Solinas et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Critical enzymes involved in endocannabinoid metabolism
Balapal S. Basavarajappa
PROTEIN AND PEPTIDE LETTERS (2007)
Consensus nomenclature for in vivo imaging of reversibly binding radioligands
Robert B. Innis et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)
A second fatty acid amide hydrolase with variable distribution among placental mammals
Binqing Q. Wei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
Matthias Blueher et al.
DIABETES (2006)
The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction
Jonathan M. Flanagan et al.
HUMAN GENETICS (2006)
Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization
EE Ustinova et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit
YH Jo et al.
NEURON (2005)
Activation of the peripheral endocannabinoid system in human obesity
S Engeli et al.
DIABETES (2005)
Fatty acid amide hydrolase controls mouse intestinal motility in vivo
R Capasso et al.
GASTROENTEROLOGY (2005)
Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH)
JC Sipe et al.
INTERNATIONAL JOURNAL OF OBESITY (2005)
Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa
P Monteleone et al.
NEUROPSYCHOPHARMACOLOGY (2005)
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
D Osei-Hyiaman et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia
Y Morita et al.
NEUROSCIENCE LETTERS (2005)
Structure and function of fatty acid amide hydrolase
MK McKinney et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2005)
The endogenous cannabinoid system protects against colonic inflammation
F Massa et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use
KP Chiang et al.
HUMAN MOLECULAR GENETICS (2004)
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders
M van der Stelt et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Modulation of anxiety through blockade of anandamide hydrolysis
S Kathuria et al.
NATURE MEDICINE (2003)
AGA technical review on irritable bowel syndrome
DA Drossman et al.
GASTROENTEROLOGY (2002)
American gastroenterological association medical position statement: Irritable bowel syndrome
GASTROENTEROLOGY (2002)
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling
MH Bracey et al.
SCIENCE (2002)
A missense mutation in human fatty acid amide hydrolase associated with problem drug use
JC Sipe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Cognitive functioning of long-term heavy cannabis users seeking treatment
N Solowij et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)
Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
AA Izzo et al.
BRITISH JOURNAL OF PHARMACOLOGY (2001)
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
BF Cravatt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Localization of CB1-cannabinoid receptor immunoreactivity in the porcine enteric nervous system
A Kulkarni-Narla et al.
CELL AND TISSUE RESEARCH (2000)
The endogenous cannabinoid system and brain development
J Fernandez-Ruiz et al.
TRENDS IN NEUROSCIENCES (2000)
Share Paper
