☆ 4.7 Review

Epstein-Barr virus and multiple sclerosis

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The Incubation Period of Primary Epstein-Barr Virus Infection: Viral Dynamics and Immunologic Events

Samantha K. Dunmire et al.

PLOS PATHOGENS (2015)

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Review Immunology

Involvement of CD8+ T Cells in Multiple Sclerosis

Marion Salou et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Review Neurosciences

Epigenetics of Multiple Sclerosis: An Updated Review

Cem Ismail Kucukali et al.

NEUROMOLECULAR MEDICINE (2015)

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EBNA2 Binds to Genomic Intervals Associated with Multiple Sclerosis and Overlaps with Vitamin D Receptor Occupancy

Vito A. G. Ricigliano et al.

PLOS ONE (2015)

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Article Clinical Neurology

Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis

Marion Salou et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)

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Article Hematology

Role for early-differentiated natural killer cells in infectious mononucleosis

Tarik Azzi et al.

BLOOD (2014)

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Article Evolutionary Biology

Genome-Wide Analysis of Wild-Type Epstein-Barr Virus Genomes Derived from Healthy Individuals of the 1000 Genomes Project

Gabriel Santpere et al.

GENOME BIOLOGY AND EVOLUTION (2014)

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Article Clinical Neurology

Oligoclonal bands in multiple sclerosis reactive against two herpesviruses and association with magnetic resonance imaging findings

J. O. Virtanen et al.

MULTIPLE SCLEROSIS JOURNAL (2014)

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Article Clinical Neurology

Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis

Michael P. Pender et al.

MULTIPLE SCLEROSIS JOURNAL (2014)

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Article Clinical Neurology

Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis

Michael P. Pender et al.

MULTIPLE SCLEROSIS JOURNAL (2014)

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Article Multidisciplinary Sciences

Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass et al.

NATURE (2014)

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Article Biochemistry & Molecular Biology

G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation

Pierre Murat et al.

NATURE CHEMICAL BIOLOGY (2014)

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Article Multidisciplinary Sciences

Quantitative Detection of Epstein-Barr Virus DNA in Cerebrospinal Fluid and Blood Samples of Patients with Relapsing-Remitting Multiple Sclerosis

Clementina E. Cocuzza et al.

PLOS ONE (2014)

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Review Oncology

Epigenetic regulation of EBV persistence and oncogenesis

Italo Tempera et al.

SEMINARS IN CANCER BIOLOGY (2014)

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Article Genetics & Heredity

Modelling the structure of full-length Epstein-Barr virus nuclear antigen 1

Mushtaq Hussain et al.

VIRUS GENES (2014)

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Article Microbiology

mRNA Structural Constraints on EBNA1 Synthesis Impact on In Vivo Antigen Presentation and Early Priming of CD8+ T Cells

Judy T. Tellam et al.

PLOS PATHOGENS (2014)

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Article Immunology

Age-Specific Prevalence of Epstein-Barr Virus Infection Among Individuals Aged 6-19 Years in the United States and Factors Affecting Its Acquisition

Henry H. Balfour et al.

JOURNAL OF INFECTIOUS DISEASES (2013)

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Article Clinical Neurology

B-Cell Enrichment and Epstein-Barr Virus Infection in Inflammatory Cortical Lesions in Secondary Progressive Multiple Sclerosis

Roberta Magliozzi et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)

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Article Clinical Neurology

Epstein-Barr virus in oral shedding of children with multiple sclerosis

Carmen Yea et al.

NEUROLOGY (2013)

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Article Cell Biology

Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection

Obinna Chijioke et al.

CELL REPORTS (2013)

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Article Microbiology

Increased CD8+T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis

Daniela F. Angelini et al.

PLOS PATHOGENS (2013)

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Peptide matching between Epstein-Barr virus and human proteins

Giovanni Capone et al.

PATHOGENS AND DISEASE (2013)

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Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation

Ekaterina Doubrovina et al.

BLOOD (2012)

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Epstein-Barr Virus Genotypes and Strains in Central Nervous System Demyelinating Disease and Epstein-Barr Virus-Related Illnesses in Australia

Meav-Lang J. Lay et al.

INTERVIROLOGY (2012)

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Letter Clinical Neurology

CD8 T cell deficiency impairs control of Epstein-Barr virus and worsens with age in multiple sclerosis

Michael P. Pender et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2012)

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Review Clinical Neurology

The initiation and prevention of multiple sclerosis

Alberto Ascherio et al.

NATURE REVIEWS NEUROLOGY (2012)

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Association of innate immune activation with latent Epstein-Barr virus in active MS lesions

J. S. Tzartos et al.

NEUROLOGY (2012)

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The EBV Immunoevasins vIL-10 and BNLF2a Protect Newly Infected B Cells from Immune Recognition and Elimination

Simon Jochum et al.

PLOS PATHOGENS (2012)

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Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1

Judy T. Tellam et al.

PLOS PATHOGENS (2012)

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Article Clinical Neurology

Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytes

Michael P. Pender et al.

BMC NEUROLOGY (2011)

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Article Clinical Neurology

Epstein-Barr virus in the multiple sclerosis brain: a controversial issue-report on a focused workshop held in the Centre for Brain Research of the Medical University of Vienna, Austria

Hans Lassmann et al.

BRAIN (2011)

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Article Immunology

Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases

Diego Franciotta et al.

JOURNAL OF NEUROIMMUNOLOGY (2011)

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Negative association of Epstein-Barr virus or herpes simplex virus-1 with tumefactive central nervous system inflammatory demyelinating disease

Takao Kiriyama et al.

JOURNAL OF NEUROVIROLOGY (2011)

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Article Medicine, General & Internal

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

Ludwig Kappos et al.

LANCET (2011)

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Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel

K. L. Munger et al.

MULTIPLE SCLEROSIS JOURNAL (2011)

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Stephen Sawcer et al.

NATURE (2011)

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The Essential Role of Epstein-Barr Virus in the Pathogenesis of Multiple Sclerosis

Michael P. Pender

NEUROSCIENTIST (2011)

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The myelin basic protein gene in multiple sclerosis: identification of discrete alleles of a 1.3 kb tetranucleotide repeat sequence

B. He et al.

ACTA NEUROLOGICA SCANDINAVICA (2010)

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Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients

Helen E. Heslop et al.

BLOOD (2010)

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Letter Clinical Neurology

Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis

Laura A. N. Peferoen et al.

BRAIN (2010)

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Upregulation of Immunoglobulin-related Genes in Cortical Sections from Multiple Sclerosis Patients

Oivind Torkildsen et al.

BRAIN PATHOLOGY (2010)

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Epstein-Barr virus antibodies in serum and cerebrospinal fluid from Multiple sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Amyotrophic Lateral Sclerosis

V. Nociti et al.

JOURNAL OF NEUROIMMUNOLOGY (2010)

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Article Clinical Neurology

Epstein-Barr Virus Latent Infection and BAFF Expression in B Cells in the Multiple Sclerosis Brain: Implications for Viral Persistence and Intrathecal B-Cell Activation

Barbara Serafini et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)

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Article Clinical Neurology

Strains of Epstein-Barr virus infecting multiple sclerosis patients

R. M. Brennan et al.

MULTIPLE SCLEROSIS JOURNAL (2010)

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Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis

S. A. Sargsyan et al.

NEUROLOGY (2010)

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Epstein Barr Virus-Encoded EBNA1 Interference with MHC Class I Antigen Presentation Reveals a Close Correlation between mRNA Translation Initiation and Antigen Presentation

Sebastien Apcher et al.

PLOS PATHOGENS (2010)

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Article Clinical Neurology

Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain

Simon N. Willis et al.

BRAIN (2009)

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Priming of protective T cell responses against virus-induced tumors in mice with human immune system components

Till Strowig et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

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Quantitative PCR for Epstein-Barr virus DNA and RNA in multiple sclerosis

J. W. Lindsey et al.

MULTIPLE SCLEROSIS JOURNAL (2009)

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Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

Melanie Bahlo et al.

NATURE GENETICS (2009)

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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

Philip L. De Jager et al.

NATURE GENETICS (2009)

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Editorial Material Clinical Neurology

Immune responses to EBNA1 Biomarkers in MS?

Jan D. Luenemann et al.

NEUROLOGY (2009)

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EBV BMRF-2 facilitates cell-to-cell spread of virus within polarized oral epithelial cells

Jianqiao Xiao et al.

VIROLOGY (2009)

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Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis

Samantha Jilek et al.

BRAIN (2008)

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EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

Jan D. Luenemann et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

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Article Clinical Neurology

Repeated subcutaneous injections of IL12/23 P40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

Benjamin M. Segal et al.

LANCET NEUROLOGY (2008)

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B-cell depletion with Rituximab in relapsing-remitting multiple sclerosis

Stephen L. Hauser et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Phase I trial of a CD8+ T-Cell peptide epitope-based vaccine for infectious mononucleosis

Suzanne L. Elliott et al.

JOURNAL OF VIROLOGY (2008)

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Recombinant gp350 vaccine for infectious mononucleosis: A phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults

Etienne M. Sokal et al.

JOURNAL OF INFECTIOUS DISEASES (2007)

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Extralymphatic virus sanctuaries as a consequence of potent T-cell activation

Mike Recher et al.

NATURE MEDICINE (2007)

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Risk alleles for multiple sclerosis identified by a genomewide study

David A. Hafler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Phase I/II studies to evaluate safety and immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy adults

Michel Moutschen et al.

VACCINE (2007)

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Characterization of the Epstein-Barr virus glycoprotein BMRF-2

Jianqiao Xiao et al.

VIROLOGY (2007)

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Treatment of solid organ transplant recipients with autologolus Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs)

Barbara Savoldo et al.

BLOOD (2006)

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Cell target genes of Epstein-Barr virus transcription factor EBNA-2:: induction of the p55α regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells

Lindsay C. Spender et al.

JOURNAL OF GENERAL VIROLOGY (2006)

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Article Clinical Neurology

Increased frequency and broadened specificity of latent EBV nuclear antigen-I-specific T cells in multiple sclerosis

Jan D. Lunemann et al.

BRAIN (2006)

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Article Clinical Neurology

Epstein-Barr virus and disease activity in multiple sclerosis

D Buljevac et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2005)

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Interferon regulatory factor 7 is negatively regulated by the Epstein-Barr virus immediate-early gene, BZLF-1

AM Hahn et al.

JOURNAL OF VIROLOGY (2005)

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Article Clinical Neurology

A randomized clinical trial of valacyclovir in multiple sclerosis

JE Friedman et al.

MULTIPLE SCLEROSIS (2005)

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Temporal relationship between elevation of Epstein-Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis

LI Levin et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

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Article Hematology

The immune response to primary EBV infection: a role for natural killer cells

H Williams et al.

BRITISH JOURNAL OF HAEMATOLOGY (2005)

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Article Biochemistry & Molecular Biology

Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis

U Dirmeier et al.

ONCOGENE (2005)

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Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells

F Pagès et al.

BLOOD (2005)

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Acute infection with Epstein-Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells

D Hochberg et al.

JOURNAL OF VIROLOGY (2004)

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Article Clinical Neurology

Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion

MH Barnett et al.

ANNALS OF NEUROLOGY (2004)

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Epstein-Barr virus and cancer

MP Thompson et al.

CLINICAL CANCER RESEARCH (2004)

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Epstein-Barr virus: 40 years on

LS Young et al.

NATURE REVIEWS CANCER (2004)

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Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases

JF Bach

NEW ENGLAND JOURNAL OF MEDICINE (2002)

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Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1

X Feng et al.

JOURNAL OF NEUROIMMUNOLOGY (2002)

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A randomized, double-blind, placebo-controlled MRI study of anti-herpes virus therapy in MS

E Bech et al.

NEUROLOGY (2002)

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The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

D Chabas et al.

SCIENCE (2001)

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Differential immunogenicity of Epstein-Barr virus latent-cycle proteins for human CD4+ T-helper 1 responses

A Leen et al.

JOURNAL OF VIROLOGY (2001)

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EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function

K Bickham et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

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Review Virology

Epstein-Barr virus entry into cells

P Speck et al.

VIROLOGY (2000)

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Article Clinical Neurology

Association between clinical disease activity and Epstein-Barr virus reactivation in MS

KP Wandinger et al.

NEUROLOGY (2000)

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Article Immunology

Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis

JM van Noort et al.

JOURNAL OF NEUROIMMUNOLOGY (2000)

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Article Immunology

Human CD4+ T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1

C Münz et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

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