Modelling and analysis of fractional-order vaccination model for control of COVID-19 outbreak using real data

In this paper, we construct the SV1V2EIR model to reveal the impact of two-dose vaccination on COVID-19 by using Caputo fractional derivative. The feasibility region of the proposed model and equilibrium points is derived. The basic reproduction number of the model is derived by using the next-generation matrix method. The local and global stability analysis is performed for both the disease-free and endemic equilibrium states. The present model is validated using real data reported for COVID-19 cumulative cases for the Republic of India from 1 January 2022 to 30 April 2022. Next, we conduct the sensitivity analysis to examine the effects of model parameters that affect the basic reproduction number. The Laplace Adomian decomposition method (LADM) is implemented to obtain an approximate solution. Finally, the graphical results are presented to examine the impact of the first dose of vaccine, the second dose of vaccine, disease transmission rate, and Caputo fractional derivatives to support our theoretical results.

Automated summary

In this paper, the SV1V2EIR model is constructed to reveal the impact of two-dose vaccination on COVID-19 using Caputo fractional derivative. The model is validated and sensitivity analysis is conducted. Results show that vaccine dosage, disease transmission rate, and Caputo fractional derivative have significant effects on the vaccine efficacy.