Distinguishing mesorectal tumor deposits from metastatic lymph nodes by using diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging in rectal cancer

Objectives This study aimed to identify whether apparent diffusion coefficient (ADC) values and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters are helpful in distinguishing mesorectal tumor deposits (TD) from metastatic lymph nodes (MLN) in rectal cancer (RC). Methods Thirty patients (59 lesions, including 30 TD and 29 MLN) with RC who underwent pretreatment-MRI between February 2016 and August 2018 were enrolled. The morphological features, ADC values, and semi-quantitative parameters of DCE-MRI, including relative enhancement (RE), maximum enhancement (ME), maximum relative enhancement (MRE), time to peak (TTP), wash-in rates (WIR), wash-out rates (WOR), brevity of enhancement (BRE), and area under the curve (AUC) were measured on lesions (TD or MLN) and RC. The parameters were compared between TD and MLN, tumor with and without TD group by using Fisher's exact test, independent-samples t-test, and Mann-Whitney U test. The ratio (lesion-to-tumor) of the parameters was compared between TD and MLN. Receiver operating characteristic curve analysis and binary logistic regression analysis were used to assess the diagnostic ability of single and combined metrics for distinguishing TD from MLN. Results The morphological features, including size, shape, and border, were significantly different between TD and MLN. TD exhibited significantly lower RE, MRE, RE-ratio, MRE-ratio, ADC(min)-ratio, and ADC(mean)-ratio than MLN. RE-ratio showed the highest AUC (0.749) and accuracy (77.97%) among single parameters. The combination of DCE-MRI and DWI parameters together showed higher diagnostic efficiency (AUC = 0.825). Conclusions Morphological features, ADC values, and DCE-MRI parameters can preoperatively help distinguish TD from MLN in RC. Key Points DWI and DCE-MRI can facilitate early detection and distinguishing mesorectal TD (tumor deposits) from MLN (metastaticlymph nodes) in rectal cancer preoperatively. TD has some specific morphological features, including relatively larger size, lower short- to long-axis ratio, irregular shape,and ill-defined border on T2-weighted MR images in rectal cancer. The combination of ADC values and semi-quantitative parameters of DCE-MRI (RE, MRE) can help to improve the diagnosticefficiency of TD in rectal cancer

Automated summary

This study aimed to investigate the role of ADC values and DCE-MRI parameters in distinguishing mesorectal tumor deposits from metastatic lymph nodes in rectal cancer. By comparing the differences in morphological features, ADC values, and DCE-MRI parameters, it was found that these parameters can help in identifying mesorectal tumor deposits and metastatic lymph nodes in advance.