Journal
JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
Volume 19, Issue 2, Pages 551-561Publisher
KOREAN SOC APPLIED ENTOMOLOGY
DOI: 10.1016/j.aspen.2016.05.003
Keywords
Healthspan; Parkinson's disease; Drosophila; Rotenone; Odor response
Categories
Funding
- Cooperative Research Program for Agriculture Science & Technology Development (Project title: Elucidation the health improvement effects of boiled silk worm larvae) Rural Development Administration [PJ010828012016]
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Recent improvements in hygiene and innovations in medical technology have dramatically extended the average lifespan of humans in developed countries. However, extension of lifespan does not correlate with increased healthspan. In this study, we examined the health benefits of mature silk worm larvae enriched with diverse functional materials. We found that Drosophila reared on food containing boiled and freeze-dried mature silk worm larval powder (BMSPF) showed a significantly increased healthspan with an extended lifespan compared to normal food (NF) flies. In addition, BMSPF flies showed a significantly increased resistance to rotenone induced Parkinson's disease symptoms compared with NF flies. The results from microarray gene profiling, quantitative real-time PCR (QRT-PCR), and odorant response assays suggested that BMSPF flies may have improved olfactory responses compared with NF flies. In addition, integrity of mitochondria was significantly enhanced in BMSPF flies. Taken together, our data suggest that BMSP can be used to extend healthspan and prevent onset and progression of PD symptoms induced in Drosophila. (C) 2016 Published by Elsevier B.V. on behalf of Korean Society of Applied Entomology, Taiwan Entomological Society and Malaysian Plant Protection Society.
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