Journal
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Volume 5, Issue 6, Pages -Publisher
WILEY-BLACKWELL
DOI: 10.1161/JAHA.116.003371
Keywords
atherosclerosis; cardiac biomarkers; cardiac computed tomography; coronary artery calcium; coronary artery disease; coronary computed tomography scan; epidemiology; HIV; HIV infection; inflammation
Categories
Funding
- National Heart Lung and Blood Institute (NHLBI) [RO1 HL095129]
- National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH) [UL1 RR 025005]
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Cancer Institute (NCI) [UO1-AI-35042, UL1-RR025005, UM1-AI-35043, UO1-AI-35039, UO1-AI-35040, UO1-AI-35041]
- CTSI grant [UL1TR000124]
- National Heart, Lung, and Blood Institute grant [5K23HL128164A]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB) training grant [5T32EB009035-06A1]
- NIH Roadmap for Medical Research
Ask authors/readers for more resources
Background-Despite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575 HIV+ and 348 HIV- men) who underwent noncontrast computed tomography scans for coronary artery calcification, the majority (n=692) also undergoing coronary computed tomography angiography. Methods and Results-Outcomes included presence and extent of coronary artery calcification, plus computed tomography angiography analysis of presence, composition, and extent of coronary plaques and severity of coronary stenosis. HIV+ men had significantly higher levels of interleukin-6 (IL-6), intercellular adhesion molecule-1, C-reactive protein, and soluble-tumor necrosis factor-a receptor (sTNF alpha R) I and II (all P<0.01) and a higher prevalence of noncalcified plaque (63% versus 54%, P=0.02) on computed tomography angiography. Among HIV+ men, for every SD increase in log-interleukin-6 and log intercellular adhesion molecule-1, there was a 30% and 60% increase, respectively, in the prevalence of coronary stenosis >= 50% (all P<0.05). Similarly, sTNF alpha R I and II in HIV+ participants were associated with an increase in prevalence of coronary stenosis >= 70% (P<0.05). Higher levels of interleukin-6, sTNF alpha R I, and sTNF alpha R II were also associated with greater coronary artery calcification score in HIV+ men (P<0.01). Conclusions-Higher inflammatory marker levels are associated with greater prevalence of coronary stenosis in HIV+ men. Our findings underscore the need for further study to elucidate the relationships of inflammatory pathways with coronary artery disease in HIV+ individuals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available