Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1870, Issue 1, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2023.166858
Keywords
Alzheimer's disease; Rlip protein; Mitochondrial dysfunction; Oxidative stress
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Alzheimer's disease is a common neurodegenerative disease, and RalBP1 protein plays an important role in it. Mutations in APP and Tau proteins interact with the Rlip protein, leading to decreased Rlip function.
Alzheimer's disease (AD) is a neurodegenerative disease that affects a large proportion of the aging population. RalBP1 (Rlip) is a stress-activated protein, that plays an important role in aging and neurodegenerative diseases such as Alzheimer's disease. Mutant APP and mutant Tau interact with the Rlip protein which leads to decreased wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease. Rlip is a promising new target for aging, Alzheimer's disease, and other neurological diseases.
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