Journal
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Volume 5, Issue 7, Pages -Publisher
WILEY
DOI: 10.1161/JAHA.116.003328
Keywords
atherosclerotic cardiovascular diseases; cardiovascular diseases; estimated glomerular filtration rate; Framingham Risk Score; reduced kidney function
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Funding
- National Clinical Research Center for Metabolic Diseases [2013BAI09B13]
- Ministry of Health [201502007]
- Ministry of Science and Technology [2015BAI12B14]
- National Basic Research Program of China (973 Program) [2015CB553601]
- National Natural Science Foundation of China [81321001, 81390350, 81130016, 81561128019]
- Chenxing Plan of Shanghai Jiaotong University
- Shuguang Plan [15SG15]
- Gaofeng Clinical Medicine Grant from Shanghai Municipal Education Commission [20152202]
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Background-Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear. Methods and Results-This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10-year Framingham risk for coronary heart disease (CHD), and 10-year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239 832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer-assisted questionnaire, we collected information on CVD, including reported CHD, stroke, or myocardial infarction. Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation was used to calculate eGFR. Compared with individuals with normal eGFR (>= 90 mL/min per 1.73 m(2)), those with decreased eGFR (75-89, 60-74, and <60 mL/min per 1.73 m(2)) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.001). Moreover, a significantly higher 10-year Framingham risk for CHD and 10-year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60-89 mL/min per 1.73 m(2)). Conclusions-Even mildly reduced eGFR (under 90 mL/min per 1.73 m(2)) is associated with elevated 10-year Framingham risk for CHD and 10-year ASCVD risk among Chinese adults.
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