Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 66, Issue 5, Pages 221-234Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1201765
Keywords
Cell sheet detachment; physical adsorption; poly (N-isopropylacrylamide); thermoresponsive polymers
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Funding
- Irish Research Council [RCS810]
- Program for Research in Third Level Institutions (PRTLI) cycle [5]
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Physical adsorption was used to produce nanometer thick thermoresponsive films with a view to nonenzymatic cell detachment. Two polymers were investigated, poly-(N-isopropylacrylamide) and poly (N-isopropylacrylamide-co-N-tertbutylacrylamide). Substrates were prepared above and below the polymers' LCST to investigate the effect of polymer conformation on the prepared substrates. Endothelial cells were seeded on the prepared films; cell proliferation was higher on the films produced below the polymers' LCST than on those prepared above and cells detached from the surfaces upon temperature reduction. Physical adsorption of poly-(N-isopropylacrylamide)-based films is a viable approach to produce substrates compliant with cell growth and temperature modulated detachment. [GRAPHICS] .
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