Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 65, Issue 15, Pages 751-758Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1163568
Keywords
Charge tunable; chitosan; particles; tartaric acid; water soluble
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Funding
- NSF [NSF-CBET 1159500]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1159500] Funding Source: National Science Foundation
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The authors report the spontaneous formation of water-soluble chitosan-tartaric acid (CS-TA) spherical particles. Particles are formed by heating chitosan in the presence of tartaric acid under hydrothermal conditions. Tartaric acid serves as an ionic cross-linker, a depolymerizing agent, and a particle stabilizer in aqueous phase. The CS-TA particles exhibit superior colloidal stability at a wide pH range due to their surface charge tunability, which is due to the colocalization of surface hydroxyl, amine, and carboxyl groups. At physiological pH condition, particles have zwitterionic structure as determined by the zeta potential measurements. Still, CS-TA maintains colloidal stability at neutral pH due to the abundance of surface hydroxyl groups. As a proof-of-concept study, the CS-TA particles were labeled with a model insoluble cargo (fluorescein isothiocyanate [FITC]) to demonstrate their capacity for solubilizing hydrophobic drugs. The CS-TA/FITC conjugates were found to remain well dispersed at neutral pH, while maintaining FITC fluorescence properties. [GRAPHICS] .
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