Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 66, Issue 3, Pages 139-148Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1190929
Keywords
Electrospun nanofiber; covalent immobilization; poly(m-antranilic acid); RGD peptide; in vitro cell studies
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Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) [213M469, 2211C]
- Portuguese Foundation for Science and Technology (FCT) [PEst-OE/FIS/UI0068/2011]
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RGD functionalized nanofibers of poly(epsilon-caprolactone)/poly(m-anthranilic acid) (PCL/P3ANA) were fabricated to address the mechanical, structural and functional requirements of bone tissue engineering. Nanofibers containing the highest amount of P3ANA with more carboxyl groups for functionalization have exhibited higher surface area and better mechanical properties. FTIR-ATR and UV-visible measurements evidenced the covalent RGD immobilization. After RGD peptide immobilization, the surface properties of nanofibers changed as evidenced by contact angle and electrochemical impedance spectroscopy (EIS). The effects of RGD functionalized nanofibers (PCL/P3ANA-RGD) on Saos-2 cell attachment, proliferation, and osteogenic activity were investigated. PCL/P3ANA-RGD nanofibers favored cell attachment, proliferation, and osteogenic activity.
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