Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 66, Issue 2, Pages 61-70Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1182912
Keywords
Chitosan; pullulan; sponge; wound dressing
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Funding
- National Natural Science Foundation of China [21174054, 21004030, 51503001]
- Natural Science Foundation of Anhui Province of China [1408085MB26]
- Research Foundation for Key Program of Education Department of Anhui Province of China [KJ2016A030]
- Doctor Research Foundation of Anhui University [J10113190075]
- Academic and Technology Introduction Project of Anhui University [AU02303203]
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The crosslinked succinyl pullulan-carboxymethyl chitosan composite sponges (Pullulan-CMCS) were fabricated for potential wound dressing. The structure and micromorphology of Pullulan-CMCS sponges were investigated by FTIR spectroscopy and SEM. Pullulan-CMCS sponges had lots of porous structures, making it absorb much liquid and quickly reach swelling equilibrium. WVTR results showed that Pullulan-CMCS sponges can reduce the accumulation of wound exudates in a certain degree. Biocompatibility test showed these sponges had no cytotoxicity or hemolytic potential. In vivo experiments demonstrated that Pullulan-CMCS sponges can effectively heal full-layer wound of skin defects of male ICR mice with accelerated fibroblast proliferation and enhanced epithelial migration.
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