NH4I-promoted electrosynthesis of 2-aminothiazole derivatives from ketone compounds and NH4SCN

A novel and efficient electrochemical synthesis of 2-aminothiazole derivatives from ketones and NH4SCN is described. Under the co-action of NH3 and iodine free radicals or iodine (I-2) electrochemically generated in situ, the target product 2-aminothiazole derivatives could be successfully obtained in good to excellent yields.

Automated summary

A novel and efficient electrochemical synthesis method was reported for the synthesis of 2-aminothiazole derivatives from ketones and NH4SCN. The target product could be obtained in good to excellent yields through the co-action of NH3 and iodine free radicals or electrochemically generated iodine (I-2).