☆ 4.7 Article

Safety and antidiabetic activity of Lagenaria siceraria (Molina) Standl. juice in streptozotocin-induced diabetic rats

JOURNAL OF ETHNOPHARMACOLOGY (2024)

Related references

Note: Only part of the references are listed.

Article Plant Sciences

Combining LC-MS/MS profiles with network pharmacology to predict molecular mechanisms of the hyperlipidemic activity of Lagenaria siceraria stand

Subhadip Banerjee et al.

Summary: Lagenaria siceraria Stand. (bottle gourd) is traditionally used in Ayurvedic medicine for hypertension and obesity. This study investigated the lead compounds from bottle gourd and their mechanisms of action in obesity and hypertension. Metabolite screening, animal studies, and network pharmacology analyses were performed. The results showed that the compounds from bottle gourd improved lipid profiles in hyperlipidemic animals and acted through the insulin and ErbB signaling pathways. These findings suggest that bottle gourd could be a natural alternative for managing hyperlipidemia.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

Add to Collection

Review Endocrinology & Metabolism

A Century-long Journey From the Discovery of Insulin to the Implantation of Stem Cell-derived Islets

Adam Ramzy et al.

Summary: Insulin injections have saved many lives, but glycemic instability remains a challenge for people with diabetes. Islet transplantation research suggests that replacing insulin-producing beta cells can restore normal blood sugar levels. Pluripotent stem cells could provide an unlimited supply of beta cells, but more research and development is needed.

ENDOCRINE REVIEWS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Nuclear factor-kappa B (NF-ΚB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases

Khalid Saad Alharbi et al.

Summary: Nutraceuticals, as dietary supplements, have the potential to improve health, prevent diseases, and maintain normal body function. This review discusses the medical value of nutraceuticals in targeting the NF-kappa B pathway to mitigate inflammatory lung diseases.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Lipid-induced monokine cyclophilin-A promotes adipose tissue dysfunction implementing insulin resistance and type 2 diabetes in zebrafish and mice models of obesity

Dipanjan Banerjee et al.

Summary: Research suggests that the interaction between macrophages and adipocytes in obese individuals can lead to insulin resistance. This study found that a lipid-induced compound called CyPA significantly impairs adipocyte functions and insulin sensitivity. Inhibition of CyPA reduces adipose tissue inflammation and restores adipocyte function, improving insulin sensitivity. Mechanistically, the interaction between CyPA and its receptor CD147 activates a signaling pathway that promotes adipocyte inflammation and inhibits adipocyte differentiation. Inhibiting CyPA or CD147 can restore adipose tissue function and insulin sensitivity.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Add to Collection

Article Food Science & Technology

Exploring the potential of bottle gourd (Lagenaria siceraria) flour as a fat mimetic in biscuits with improved physicochemical and nutritional characteristics and anti-diabetic properties

Syed Muhammad Ghufran Saeed et al.

Summary: The study investigated the effect of bottle gourd flour as a fat mimetic in biscuits. Results showed that it had potential bioactivity and anti-diabetic properties. It did not affect the storage stability and sensory properties of the biscuits.

ITALIAN JOURNAL OF FOOD SCIENCE (2022)

Add to Collection

Article Food Science & Technology

Dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucagon-like peptide (GLP-1) secretion in arsenically safe pigmented red rice (Oryza sativa L.) and its product

Duyi Samyor et al.

Summary: This study assessed the effects of pigmented and non-pigmented rice, as well as an extruded food product, on DPP-4 inhibition and GLP-1 secretion. The results showed that the ethanol/water extract of rice bran had the highest DPP-4 inhibitory activity, while the extruded products stimulated GLP-1 secretion mostly through n-hexane or ethanol extraction. The extruded food items also had a lower arsenic content.

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2022)

Add to Collection

Article Plant Sciences

Antidiabetic effects of Psidium x durbanensis Baijnath & Ramcharun ined. (Myrtaceae) leaf extract on streptozotocin-induced diabetes in rats

Kingsley C. Mbara et al.

Summary: This study demonstrates the antioxidant and antidiabetic effects of PD leaf extracts on streptozotocin-induced diabetes in rats. The PD leaf extracts can improve glucose metabolism and alleviate oxidative stress in rats. Additionally, PD is found to improve insulin resistance by increasing glucose uptake in gastrocnemius muscles.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Add to Collection

Article Plant Sciences

Antidiabetic effects of Psidium x durbanensis Baijnath & Ramcharun ined. (Myrtaceae) leaf extract on streptozotocin-induced diabetes in rats

Kingsley C. Mbara et al.

Summary: The leaf extracts of Psidium x durbanensis have shown significant improvement in diabetes symptoms and oxidative stress in rats, by increasing glucose uptake in muscles and restoring histological aberrations in the pancreas and liver.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Add to Collection

Review Chemistry, Medicinal

A Comprehensive Review on the Medicinal Importance; Biological and Therapeutic Efficacy of Lagenaria siceraria (Mol.) (Bottle Gourd) Standley Fruit

Muhammad Zahoor et al.

Summary: Bottle gourd, a domestic plant from the Cucurbitaceae family, has been traditionally used as a medicinal plant with various pharmacological activities. Research on Bottle gourd has revealed its potential in treating a wide range of diseases, which highlights the importance of further studies on this plant for potential therapeutic benefits.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

α-Glucosidase, α-amylase, and tyrosinase inhibitory potential of capsaicin and dihydrocapsaicin

Kesinee Nanok et al.

JOURNAL OF FOOD BIOCHEMISTRY (2020)

Add to Collection

Article Food Science & Technology

Anti-hyperglycemic and liver protective effects of flavonoids from Psidium guajava L. (guava) leaf in diabetic mice

Xiaoai Zhu et al.

FOOD BIOSCIENCE (2020)

Add to Collection

Article Food Science & Technology

Effects of microwave combined with ultrasound treatment on the pasteurization and nutritional properties of bottle gourd (Lagenaria siceraria) juice

Manas Jyoti Das et al.

JOURNAL OF FOOD PROCESSING AND PRESERVATION (2020)

Add to Collection

Article Plant Sciences

In vitro antioxidant, antidiabetic, antiacetylcholine esterase, anticancer activities and RP-HPLC analysis of phenolics from the wild bottle gourd (Lagenaria siceraria (Molina) Standl.)

U. A. Attar et al.

SOUTH AFRICAN JOURNAL OF BOTANY (2019)

Add to Collection

Review Medicine, General & Internal

Mapping the evidence of hepatoprotective properties of Moringa oleifera from sub-Saharan African countries: a systematic review protocol

Willy Tambwe Muzumbukilwa et al.

SYSTEMATIC REVIEWS (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Antidiabetic Potential of Monoterpenes: A Case of Small Molecules Punching above Their Weight

Solomon Habtemariam

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents beta-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats

Muthukumaran Jayachandran et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Add to Collection

Article Agricultural Engineering

Antioxidant, anti-diabetic, acetylcholinesterase inhibitory potential and estimation of alkaloids (lycorine and galanthamine) from Crinum species: An important source of anticancer and anti-Alzheimer drug

S. G. Ghane et al.

INDUSTRIAL CROPS AND PRODUCTS (2018)

Add to Collection

Article Food Science & Technology

EFFECT OF THERMAL AND ALTERNATE THERMAL PROCESSING ON BOTTLE GOURD (LAGENARIA SICERARIA) JUICE

Suheela Bhat et al.

JOURNAL OF FOOD PROCESSING AND PRESERVATION (2017)

Add to Collection

Review Pharmacology & Pharmacy

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes

Sachin V. Suryavanshi et al.

FRONTIERS IN PHARMACOLOGY (2017)

Add to Collection

Review Tropical Medicine

Antihyperglycemic effect of Ocimum plants: A short review

Raiya Adiba Antora et al.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2017)

Add to Collection

Review Biochemistry & Molecular Biology

The Traditional Medicine and Modern Medicine from Natural Products

Haidan Yuan et al.

MOLECULES (2016)

Add to Collection

Article Medicine, General & Internal

Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links

Abdo Jurjus et al.

BBA CLINICAL (2016)

Add to Collection

Article Critical Care Medicine

Acute and sub-acute toxicity studies of aqueous and methanol extracts of Nelsonia campestris in rats

Janet Mobolaji Olaniyan et al.

JOURNAL OF ACUTE DISEASE (2016)

Add to Collection

Article Multidisciplinary Sciences

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

P. S. Unnikrishnan et al.

FRONTIERS IN LIFE SCIENCE (2015)

Add to Collection

Article Critical Care Medicine

Evaluation of acute and subacute toxicity induced by methanol extract of Terminalia citrina leaves in Sprague Dawley rats

Narhari Das et al.

JOURNAL OF ACUTE DISEASE (2015)

Add to Collection

Review Pharmacology & Pharmacy

Advanced Glycation End Products and Diabetic Complications

Varun Parkash Singh et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2014)

Add to Collection

Review Endocrinology & Metabolism

Insulin resistance and hyperglycaemia in cardiovascular disease development

Markku Laakso et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Add to Collection

Article Agriculture, Multidisciplinary

Antioxidant and α-Glucosidase Inhibitory Activities of Cucurbit Fruit Vegetables and Identification of Active and Major Constituents from Phenolic-rich Extracts of Lagenaria siceraria and Sechium edule

Shaida Fariza Suaiman et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2013)

Add to Collection

Article Integrative & Complementary Medicine

Alleviation of diabetes induced dyslipidemia by Lagenaria siceraria fruit extract in human type 2 diabetes

Charu Katare et al.

JOURNAL OF HERBAL MEDICINE (2013)

Add to Collection

Article Nutrition & Dietetics

Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy

Vivian Soetikno et al.

NUTRITION & METABOLISM (2011)

Add to Collection

Article Medicine, Research & Experimental

DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats

Xiaodong Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2010)

Add to Collection

Review Biochemistry & Molecular Biology

Inflammation and insulin resistance

Carl de Luca et al.

FEBS LETTERS (2008)

Add to Collection

Review Biochemistry & Molecular Biology

Free radicals, metals and antioxidants in oxidative stress-induced cancer

M Valko et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2006)

Add to Collection

Correction Biochemistry & Molecular Biology

Streptozotocin-induced diabetic nephropathy in rats: The role of inflammatory cytokines (vol 31, pg 180, 2005)

E. P. K. Mensah-Brown et al.

CYTOKINE (2006)

Add to Collection

Article Plant Sciences

Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats

A Shirwaikar et al.

JOURNAL OF ETHNOPHARMACOLOGY (2004)

Add to Collection

Review Biotechnology & Applied Microbiology

Oxidative DNA damage and disease: induction, repair and significance

MD Evans et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2004)

Add to Collection

Review Biochemistry & Molecular Biology

NF-κB as a therapeutic target in chronic inflammation:: recent advances

SS Makarov

MOLECULAR MEDICINE TODAY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.