☆ 4.7 Review

mRNA vaccines in disease prevention and treatment

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Phenylalanine hydroxylase mRNA rescues the phenylketonuria phenotype in mice

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Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Yuncong Shi et al.

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mRNA-based therapeutics: powerful and versatile tools to combat diseases

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A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

Christina Krienke et al.

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Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA

Fatima Rizvi et al.

Summary: The study introduces a potentially translatable therapeutic intervention for liver regeneration, utilizing mRNA-LNP delivery to induce hepatocyte proliferation and accelerate liver function recovery in murine models of acute and chronic liver injury.

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Nanomaterial Delivery Systems for mRNA Vaccines

Michael D. Buschmann et al.

Summary: This review highlights the recent success of mRNA vaccines in SARS-CoV-2 clinical trials, emphasizing the crucial role of lipid nanoparticles in the delivery systems and providing an analysis of the determinants of lipid nanoparticles' performance in mRNA vaccines.

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BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

Yingnan Geng et al.

Summary: The study explores the potential of using chemically modified mRNAs encoding hBMP-2 and VEGF-A to therapeutically heal bone injuries. By inoculating bone marrow stem cells treated with these modRNAs in a collagen scaffold, superior healing properties were observed, showcasing the synergistic effects of hBMP-2 and VEGF-A in driving osteogenic and angiogenic pathways for potential clinical applications in bone injury treatment.

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

Peng Zhang et al.

Summary: An mRNA vaccine platform showed promising results in generating broadly neutralizing antibodies in non-human primates and reducing the risk of infection, highlighting its potential for developing an effective HIV-1 vaccine.

NATURE MEDICINE (2021)

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mRNA vaccine for cancer immunotherapy

Lei Miao et al.

Summary: mRNA vaccines have emerged as a promising platform for cancer immunotherapy, showcasing high potency, safe administration, rapid development potentials, and cost-effective manufacturing. However, challenges such as stability, innate immunogenicity, and inefficient in vivo delivery restrict their applications. In addressing these challenges, structural modifications and formulation methods are being researched to enhance the anti-tumor immune response.

MOLECULAR CANCER (2021)

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mRNA in cancer immunotherapy: beyond a source of antigen

Lien Van Hoecke et al.

Summary: mRNA therapeutics have become a focus in molecular medicine research, particularly in the field of immuno-oncology. The versatility and advantages of mRNA go beyond cancer vaccine development, with potential for endless therapeutic applications through smart design and pharmaceutical formulations. Novel immunotherapeutic strategies are now exploring the use of mRNA beyond tumor antigens as a source, showing promise for clinical applications.

MOLECULAR CANCER (2021)

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Review Virology

The Past, the Present, and the Future of the Size Exclusion Chromatography in Extracellular Vesicles Separation

Hussein Kaddour et al.

Summary: Extracellular vesicles (EVs) are cell-derived membranous particles that carry and transport bioactive cargoes to recipient cells, playing important roles in physiological and pathophysiological processes. Efficient protocols for EV separation are currently lacking, but SEC-based methods show promise and future development of PPLC system for improved separation is suggested.

VIRUSES-BASEL (2021)

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Review Oncology

Immunomodulating Therapies in Breast Cancer-From Prognosis to Clinical Practice

Marcus Schmidt et al.

Summary: The immune system plays a crucial role in breast cancer, particularly in triple negative breast cancer. Personalized mRNA vaccines targeting tumor-specific neoantigens and immune checkpoint inhibitors are emerging as promising treatment strategies.

CANCERS (2021)

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Article Immunology

Development of multivalent mRNA vaccine candidates for seasonal or pandemic influenza

Sudha Chivukula et al.

Summary: The recent approval of mRNA vaccines for emergency use against COVID-19 is likely to accelerate the development of mRNA-based vaccines targeting a wide range of infectious diseases. This vaccine modality promises comparable potency while accelerating the development and deployment of vaccine doses. Demonstrated successfully for single antigen vaccines, the technology could be optimized for complex multi-antigen vaccines.

NPJ VACCINES (2021)

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mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients

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Summary: mRNA vaccines are considered a modern option for cancer treatment, with advantages such as rapid production, low manufacturing costs, and the ability to induce both cellular and humoral immune responses. However, their use is also associated with challenges that require extensive trials to validate their efficacy.

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A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice

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Summary: The LUNAR-COV19 vaccine has been successfully developed to induce strong antibody response and cell-mediated immune response in mice. The vaccine at different doses can completely protect mice from SARS-CoV-2 challenge.

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mRNA vaccines manufacturing: Challenges and bottlenecks

Sara Sousa Rosa et al.

Summary: mRNA vaccines are emerging as a new alternative to conventional vaccines, with their precision, safety profile, and flexible manufacturing. They have been used to combat the Covid-19 pandemic and are being studied for other diseases as well. However, challenges in manufacturing, technology platform, and cost-effective production need to be addressed to fully utilize this new vaccination technology.

VACCINE (2021)

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Review Oncology

Exploiting Tumor Neoantigens to Target Cancer Evolution: Current Challenges and Promising Therapeutic Approaches

Ravi G. Gupta et al.

Summary: Immunotherapeutic manipulation targets genomic instability in cancer by activating T cells, but tumors can evade immune recognition through immunoediting and immunosuppressive mechanisms. Challenges in neoantigen-directed therapy include low frequency of immunogenic neoantigens and tumor cell immune evasion mechanisms.

CANCER DISCOVERY (2021)

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Article Immunology

mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents

Susanne Rauch et al.

Summary: mRNA technologies have shown clinical efficacy against COVID-19, with the CVnCoV vaccine demonstrating strong immune responses and protection against SARS-CoV-2 in preclinical studies. Overall, CVnCoV represents a potent and safe candidate for a COVID-19 vaccine.

NPJ VACCINES (2021)

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Review Chemistry, Multidisciplinary

From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer

Madiha Saeed et al.

Summary: This article discusses how nanotechnology-based methods can promote anti-tumor immune responses, with a focus on the importance of normalizing the tumor immune microenvironment. By targeting immunosuppressive cells and signaling pathways, nanomedicine has the potential to enhance the impact of cancer immunotherapy.

ADVANCED MATERIALS (2021)

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Article Cell & Tissue Engineering

Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)

S. Michaela Rikard et al.

Summary: This study developed a mathematical model predicting the spatial distribution of VEGF-A to accelerate diabetic wound healing. Experimental and simulated results suggest the critical importance of drug delivery location and drug diffusivity in treating diabetic wounds.

CELLULAR AND MOLECULAR BIOENGINEERING (2021)

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Review Oncology

Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response

Tong Fu et al.

Summary: Tumors are not only collections of malignant cells, but also organized complex ecosystems. With the emergence of innovative technologies, researchers can more accurately understand the spatial architecture of the tumor immune microenvironment (TIME), improving our knowledge of tumor biology. The spatial architecture of TIME plays a crucial role in tumor biology and is influenced by the gradient of extracellular nonspecific chemicals (ENSCs).

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Medicine, General & Internal

Cystic fibrosis

Michal Shteinberg et al.

LANCET (2021)

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Review Medicine, General & Internal

Prostate cancer

Shahneen Sandhu et al.

Summary: Management of prostate cancer is rapidly evolving with advances in understanding the genomic landscape, improved imaging methods, and personalised therapeutics targeting DNA repair pathways. The therapeutic framework for metastatic disease has shifted, with oligometastatic disease being evaluated for metastatic-directed therapies, and novel androgen pathway inhibitors showing significant survival benefits as first-line therapy for metastatic disease. Emerging research into molecular characterisation and novel therapeutics, such as targeted radioisotopes and immunotherapy, hold promise for improving patient outcomes.

LANCET (2021)

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Review Biotechnology & Applied Microbiology

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

Namit Chaudhary et al.

Summary: mRNA vaccines have been established as a rapid, effective, and safe approach for protecting individuals from infectious diseases, especially during the COVID-19 pandemic. Further research is needed to optimize mRNA vaccine design, delivery, and applications for a range of infectious diseases.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Immunology

Pre-existing immunity to cytomegalovirus in macaques influences human CMV vaccine responses in preclinical models

Helen Webster et al.

Summary: The study shows that species-specific CMV variant-specific antibody responses contribute to the immunogenicity of HCMV vaccines, indicating the necessity of considering pre-existing immunity in non-human primate models and the impact of different species' immune responses post-vaccination.

VACCINE (2021)

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Article Medicine, General & Internal

Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2 A phase 1 randomized clinical trial

Peter G. Kremsner et al.

Summary: The RNActive technology platform was used to prepare CVnCoV, a COVID-19 vaccine containing optimized mRNA encoding for a stabilized form of SARS-CoV-2 spike protein. The dosage escalation phase 1 study showed that 12 µg of CVnCoV vaccine elicited immune responses comparable to those seen in convalescent sera from COVID-19 patients, with acceptable safety and reactogenicity.

WIENER KLINISCHE WOCHENSCHRIFT (2021)

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Article Multidisciplinary Sciences

mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease

Jingsong Cao et al.

Summary: Glycogen Storage Disease 1a (GSD1a) is a rare inherited metabolic disorder characterized by hypoglycemia and high risk of liver cancer. In this study, researchers developed an mRNA-based G6Pase-alpha delivery therapy that was shown to be efficacious and safe in a mouse model of GSD1a.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema

Daniel Szoke et al.

Summary: Dysfunction of the lymphatic system leads to secondary lymphedema and decreases quality of life. Researchers demonstrate that delivery of nucleoside-modified Vascular Endothelial Growth Factor C (VEGFC) mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema.

NATURE COMMUNICATIONS (2021)

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Article Medicine, General & Internal

Phenylketonuria

Francjan J. van Spronsen et al.

Summary: Phenylketonuria is an inherited disorder of phenylalanine metabolism that can lead to severe neurological dysfunction if left untreated. Early diagnosis and treatment have a significant impact on patients' intelligence, with dietary restriction being the mainstay of current treatment.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Pharmacology & Pharmacy

mRNA-Based Anti-TCR CDR3 Tumour Vaccine for T-Cell Lymphoma

Marina Tusup et al.

Summary: Efficient vaccination with ivt mRNA can trigger immunity against TCR CDR3 regions in T-cell lymphomas, offering protection and potential therapeutic effects against the disease.

PHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

Hui Zhao et al.

Summary: mRNA vaccine technology has shown effectiveness in preventing the ongoing COVID-19 pandemic, with the ARCoV vaccine demonstrating protective efficacy in mouse and macaque models. Notably, ARCoV showed the ability to maintain stability at refrigerator temperatures for extended periods of time, supporting its ongoing clinical trial.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy

Tianyu Tang et al.

Summary: The tumor immune microenvironment plays a critical role in cancer immunity, and regulators within it could be promising targets for cancer immunotherapy, alone or in combination with immune checkpoint-targeting drugs.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Immunology

A guide to vaccinology: from basic principles to new developments

Andrew J. Pollard et al.

Summary: Immunization is vital for public health policy and there are challenges ahead for immunologists in developing new vaccines. Although immunology has not contributed significantly to vaccine development so far, a better understanding of protective immunity is urgently needed to tackle difficult-to-target pathogens.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Immunology

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

Ronen Alon et al.

Summary: The understanding of COVID-19 clinical manifestations requires knowledge of how immune cells are recruited to virus-infected lungs and how this recruitment varies among individuals. The orchestration of leukocyte trafficking to respiratory system is controlled by specific molecules, which can lead to pathological complications when uncontrolled. The incomplete understanding of trafficking signals in response to SARS-CoV-2 infection calls for further research for potential therapeutic interventions.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

A phase 1, randomized, placebo-controlled study to evaluate the safety and immunogenicity of an mRNA-based RSV prefusion F protein vaccine in healthy younger and older adults

Antonios O. Aliprantis et al.

Summary: This study evaluated the safety, tolerability, and immunogenicity of a new RSV vaccine in healthy younger and older adults. All doses of the vaccine were well tolerated and induced both humoral and cell-mediated immune responses.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Review Biochemistry & Molecular Biology

Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response

Sergio Linares-Fernandez et al.

TRENDS IN MOLECULAR MEDICINE (2020)

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Article Virology

Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccine Elicits Antibody Responses with Greater Durability and Breadth than MF59-Adjuvanted gB Protein Immunization

Cody S. Nelson et al.

JOURNAL OF VIROLOGY (2020)

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Article Oncology

TriMix and tumor antigen mRNA electroporated dendritic cell vaccination plus ipilimumab: link between T-cell activation and clinical responses in advanced melanoma

Brenda De Keersmaecker et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Pharmacology & Pharmacy

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Abishek Wadhwa et al.

PHARMACEUTICS (2020)

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Review Immunology

The promise of mRNA vaccines: a biotech and industrial perspective

Nicholas A. C. Jackson et al.

NPJ VACCINES (2020)

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Article Immunology

Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection

Amy S. Espeseth et al.

NPJ VACCINES (2020)

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Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Cell Biology

Priorities for developing respiratory syncytial virus vaccines in different target populations

Simon B. Drysdale et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Immunology

Current Status of Zika Virus Vaccines: Successes and Challenges

Aryamav Pattnaik et al.

VACCINES (2020)

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Article Oncology

A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases

Yanina Jansen et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

A Thermostable mRNA Vaccine against COVID-19

Na-Na Zhang et al.

CELL (2020)

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Review Immunology

Current Challenges in Vaccinology

Richard B. Kennedy et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins

Andrew S. Khalil et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Kizzmekia S. Corbett et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

Mark J. Mulligan et al.

NATURE (2020)

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Article Multidisciplinary Sciences

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

Ugur Sahin et al.

NATURE (2020)

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Article Medicine, General & Internal

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Kizzmekia S. Corbett et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

An mRNA Vaccine against SARS-CoV-2-Preliminary Report

L. A. Jackson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

DNA-based fluorescent probes of NOS2 activity in live brains

Aneesh T. Veetil et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Immunology

Immunogenicity generated by mRNA vaccine encoding VZV gE antigen is comparable to adjuvanted subunit vaccine and better than live attenuated vaccine in nonhuman primates

Morgan A. Monslow et al.

VACCINE (2020)

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Review Biochemistry & Molecular Biology

mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection

Shuqin Xu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Medicine, Research & Experimental

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Gal Cafri et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Chemistry, Multidisciplinary

Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection

Gustavo Lou et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Medicine, General & Internal

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

Edward E. Walsh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

E. J. Anderson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia

Lei Jiang et al.

NATURE COMMUNICATIONS (2020)

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Article Immunology

Therapeutic vaccines for colorectal cancer: The progress and future prospect

Mina Shahnazari et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Immunology

Toll-like receptor 7/8-matured RNA-transduced dendritic cells as post-remission therapy in acute myeloid leukaemia: results of a phase I trial

Felix S. Lichtenegger et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

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Article Cell & Tissue Engineering

An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis In Vitro and In Vivo

Wen Zhang et al.

TISSUE ENGINEERING PART A (2019)

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Article Oncology

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer

Martin Sebastian et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

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Article Pharmacology & Pharmacy

Phenylketonuria: Current Treatments and Future Developments

Uta Lichter-Konecki et al.

DRUGS (2019)

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Review Medicine, Research & Experimental

How mRNA therapeutics are entering the monoclonal antibody field

Lien Van Hoecke et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

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Review Biotechnology & Applied Microbiology

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

Giulietta Maruggi et al.

MOLECULAR THERAPY (2019)

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Review Biotechnology & Applied Microbiology

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Piotr S. Kowalski et al.

MOLECULAR THERAPY (2019)

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Article Oncology

Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer

Alexandros Papachristofilou et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Meeting Abstract Oncology

A phase I multicenter study to assess the safety, tolerability, and immunogenicity of mRNA-4157 alone in patients with resected solid tumors and in combination with pembrolizumab in patients with unresectable solid tumors.

Howard A. Burris et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Meeting Abstract Oncology

Immunogenicity and tolerability of personalized mRNA vaccine mRNA-4650 encoding defined neoantigens expressed by the autologous cancer.

Gal Cafri et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Review Endocrinology & Metabolism

Clinical and biochemical footprints of inherited metabolic diseases. II. Metabolic liver diseases

Carlos R. Ferreira et al.

MOLECULAR GENETICS AND METABOLISM (2019)

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Review Genetics & Heredity

Systematic literature review and meta-analysis on the epidemiology of methylmalonic acidemia (MMA) with a focus on MMA caused by methylmalonyl-CoA mutase (mut) deficiency

Timea Almasi et al.

ORPHANET JOURNAL OF RARE DISEASES (2019)

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Article Immunology

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

Robert A Feldman et al.

VACCINE (2019)

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Review Respiratory System

Emerging gene therapies for cystic fibrosis

Kamran M. Miah et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2019)

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Article Medicine, General & Internal

Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemia

Ding An et al.

EBIOMEDICINE (2019)

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Review Pharmacology & Pharmacy

Recent advances in polymeric materials for the delivery of RNA therapeutics

David Ulkoski et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Review Biochemistry & Molecular Biology

mRNA cap regulation in mammalian cell function and fate

Alison Galloway et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2019)

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Review Biochemistry & Molecular Biology

mRNA as novel technology for passive immunotherapy

Thomas Schlake et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Engineering, Biomedical

A bioactive collagen membrane that enhances bone regeneration

Behnoush Khorsand et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Hybrid nanovaccine for the co-delivery of the mRNA antigen and adjuvant

Jingnan Yang et al.

NANOSCALE (2019)

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Review Microbiology

The evolution of seasonal influenza viruses

Velislava N. Petrova et al.

NATURE REVIEWS MICROBIOLOGY (2018)

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Review Cell & Tissue Engineering

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

Robert L. Bowman et al.

CELL STEM CELL (2018)

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Article Biotechnology & Applied Microbiology

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

Ema Robinson et al.

MOLECULAR THERAPY (2018)

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Article Biotechnology & Applied Microbiology

Targeted mRNA Therapy for Ornithine Transcarbamylase Deficiency

Mary G. Prieve et al.

MOLECULAR THERAPY (2018)

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Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

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Article Clinical Neurology

Epidemiology of Brain Tumors

Jill S. Barnholtz-Sloan et al.

NEUROLOGIC CLINICS (2018)

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Article Biochemistry & Molecular Biology

Arginase I mRNA therapy - a novel approach to rescue arginase 1 enzyme deficiency

Kirtika H. Asrani et al.

RNA BIOLOGY (2018)

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Review Multidisciplinary Sciences

Personalized vaccines for cancer immunotherapy

Ugur Sahin et al.

SCIENCE (2018)

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Article Immunology

Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity

Shinu John et al.

VACCINE (2018)

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Review Medicine, General & Internal

Melanoma

Dirk Schadendorf et al.

LANCET (2018)

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Review Oncology

Combination treatment of advanced pancreatic cancer using novel vaccine and traditional therapies

Hiroto Matsui et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2018)

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Article Medicine, General & Internal

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Spencer L. G. James et al.

LANCET (2018)

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Review Biochemistry & Molecular Biology

Structural and molecular mechanisms for the control of eukaryotic 5 '-3 ' mRNA decay

Jeffrey S. Mugridge et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

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Review Biochemistry & Molecular Biology

Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

S. Guan et al.

GENE THERAPY (2017)

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Article Biotechnology & Applied Microbiology

ICTV Virus Taxonomy Profile: Pneumoviridae

Bert Rima et al.

JOURNAL OF GENERAL VIROLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

Gregory A. Roth et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Medicine, General & Internal

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

Martin Alberer et al.

LANCET (2017)

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Review Endocrinology & Metabolism

Propionyl-CoA carboxylase - A review

Parith Wongkittichote et al.

MOLECULAR GENETICS AND METABOLISM (2017)

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Article Biotechnology & Applied Microbiology

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

Kapil Bahl et al.

MOLECULAR THERAPY (2017)

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Article Multidisciplinary Sciences

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

Ugur Sahin et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

Norbert Pardi et al.

NATURE (2017)

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Review Biochemistry & Molecular Biology

Type I lnterferons Modulate CD8+ T Cell Immunity to mRNA Vaccines

Ans De Beuckelaer et al.

TRENDS IN MOLECULAR MEDICINE (2017)

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Article Cell Biology

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

Ding An et al.

CELL REPORTS (2017)

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Article Immunology

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

Johannes Lutz et al.

NPJ VACCINES (2017)

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Article Hematology

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

Sebastien Anguille et al.

BLOOD (2017)

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Article Oncology

Immune Responses and Long-Term Disease Recurrence Status After Telomerase-Based Dendritic Cell Immunotherapy in Patients With Acute Myeloid Leukemia

Hanna J. Khoury et al.

CANCER (2017)

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Article Biochemistry & Molecular Biology

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

Justin M. Richner et al.

CELL (2017)

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Article Pharmacology & Pharmacy

A Comparative Study of the Bone Regenerative Effect of Chemically Modified RNA Encoding BMP-2 or BMP-9

Behnoush Khorsand et al.

AAPS JOURNAL (2017)

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Article Biochemistry & Molecular Biology

Modified mRNA Vaccines Protect against Zika Virus Infection

Justin M. Richner et al.

CELL (2017)

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Article Critical Care Medicine

The Eighth Edition Lung Cancer Stage Classification

Frank C. Detterbeck et al.

CHEST (2017)

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Article Engineering, Biomedical

Chemically modified RNA induces osteogenesis of stem cells and human tissue explants as well as accelerates bone healing in rats

Elizabeth R. Balmayor et al.

BIOMATERIALS (2016)

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Review Microbiology

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

Alice Panchaud et al.

CLINICAL MICROBIOLOGY REVIEWS (2016)

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Review Pediatrics

Methylmalonic and propionic acidemias: clinical management update

Jamie L. Fraser et al.

CURRENT OPINION IN PEDIATRICS (2016)

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Article Immunology

Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial

Rajesh T. Gandhi et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2016)

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Article Chemistry, Multidisciplinary

Materials for non-viral intracellular delivery of messenger RNA therapeutics

Kevin J. Kauffman et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Medicine, General & Internal

Cystic fibrosis

J. Stuart Elborn

LANCET (2016)

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Article Clinical Neurology

Epidemiology of Brain Tumors

Katharine A. McNeill

NEUROLOGIC CLINICS (2016)

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Article Medicine, General & Internal

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

Eric Tran et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Infectious Diseases

An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs

Margit Schnee et al.

PLOS NEGLECTED TROPICAL DISEASES (2016)

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Article Microbiology

Varicella-Zoster Virus Glycoproteins: Entry, Replication, and Pathogenesis

Stefan L. Oliver et al.

CURRENT CLINICAL MICROBIOLOGY REPORTS (2016)

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Article Oncology

Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial

Yoshinari Maeda et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)

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Article Oncology

A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile

Regina Heidenreich et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

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Article Chemistry, Multidisciplinary

Chemically modified RNA activated matrices enhance bone regeneration

Satheesh Elangovan et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Editorial Material Biotechnology & Applied Microbiology

mRNA: Fulfilling the Promise of Gene Therapy

Drew Weissman et al.

MOLECULAR THERAPY (2015)

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Article Biotechnology & Applied Microbiology

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

Andreas Thess et al.

MOLECULAR THERAPY (2015)

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Article Multidisciplinary Sciences

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

Duane A. Mitchell et al.

NATURE (2015)

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Article Biochemistry & Molecular Biology

Toll-like receptor 8 senses degradation products of single-stranded RNA

Hiromi Tanji et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

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Article Biochemistry & Molecular Biology

Toll-like receptor 8 senses degradation products of single-stranded RNA

Hiromi Tanji et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

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Article Immunology

Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice

E. Hattinger et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2015)

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Article Biotechnology & Applied Microbiology

Mutanome Engineered RNA Immunotherapy (MERIT)

Ugur Sahin et al.

HUMAN GENE THERAPY CLINICAL DEVELOPMENT (2015)

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Article Medicine, General & Internal

Varicella zoster virus infection

Anne A. Gershon et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

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Review Immunology

The ReNAissanCe of mRNA-based cancer therapy

Sandra Van Lint et al.

EXPERT REVIEW OF VACCINES (2015)

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Review Immunology

Regulation of antiviral T cell responses by type I interferons

Josh Crouse et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Review Oncology

Optimized dendritic cell-based immunotherapy for melanoma: the TriMix-formula

Sandra Van Lint et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2014)

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Review Biochemical Research Methods

Ribonucleic acid purification

R. Martins et al.

JOURNAL OF CHROMATOGRAPHY A (2014)

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Review Biotechnology & Applied Microbiology

mRNA-based therapeutics - developing a new class of drugs

Ugur Sahin et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

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Article Oncology

Measures of Outcome in Metastatic Breast Cancer: Insights From a Real-World Scenario

Marta Bonotto et al.

ONCOLOGIST (2014)

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Review Biotechnology & Applied Microbiology

mRNA vaccine CV9103 and CV9104 for the treatment of prostate cancer

Steffen Rausch et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

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Article Oncology

A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients

S. Wilgenhof et al.

ANNALS OF ONCOLOGY (2013)

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Article Oncology

Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma

Einar Osland Vik-Mo et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)

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Review Microbiology

The Silent Global Burden of Congenital Cytomegalovirus

Sheetal Manicklal et al.

CLINICAL MICROBIOLOGY REVIEWS (2013)

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Review Chemistry, Physical

Delivery materials for siRNA therapeutics

Rosemary Kanasty et al.

NATURE MATERIALS (2013)

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Article Immunology

Generation of CTL responses against pancreatic cancer in vitro using dendritic cells co-transfected with MUC4 and survivin RNA

Jiang Chen et al.

VACCINE (2013)

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Review Biotechnology & Applied Microbiology

A novel, disruptive vaccination technology Self-adjuvanted RNActive® vaccines

Karl-Josef Kallen et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2013)

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Review Pharmacology & Pharmacy

Cationic lipids activate intracellular signaling pathways

Caroline Lonez et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Article Oncology

Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients

Erik H. J. G. Aarntzen et al.

CLINICAL CANCER RESEARCH (2012)

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Editorial Material Pharmacology & Pharmacy

Glycogen storage disease type Ia: Linkage of glucose, glycogen, lactic acid, triglyceride, and uric acid metabolism

Sakine Sever et al.

JOURNAL OF CLINICAL LIPIDOLOGY (2012)

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Article Biotechnology & Applied Microbiology

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

Benjamin Petsch et al.

NATURE BIOTECHNOLOGY (2012)

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Review Microbiology

Conventional and unconventional mechanisms for capping viral mRNA

Etienne Decroly et al.

NATURE REVIEWS MICROBIOLOGY (2012)

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Article Oncology

hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes

Else M. Inderberg Suso et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2011)

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Article Oncology

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

Mariola Fotin-Mleczek et al.

JOURNAL OF IMMUNOTHERAPY (2011)

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Article Oncology

Induction of cytotoxic T lymphocytes primed with Tumor RNA-loaded Dendritic Cells in esophageal squamous cell carcinoma: preliminary step for DC vaccine design

Mehran Gholamin et al.

BMC CANCER (2010)

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Review Allergy

Prophylactic mRNA vaccination against allergy

Richard Weiss et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Multidisciplinary Sciences

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

Viggo F. Van Tendeloo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Microbiology

Genome-Wide Mutagenesis Reveals That ORF7 Is a Novel VZV Skin-Tropic Factor

Zhen Zhang et al.

PLOS PATHOGENS (2010)

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Review Chemistry, Multidisciplinary

Nonviral Vectors for Gene Delivery

Meredith A. Mintzer et al.

CHEMICAL REVIEWS (2009)

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Article Cell & Tissue Engineering

Clinical-grade manufacturing of autologous mature mRNA-electroporated dendritic cells and safety testing in acute myeloid leukemia patients in a phase I dose-escalation clinical trial

Ann Van Driessche et al.

CYTOTHERAPY (2009)

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Article Allergy

Immunize and disappear-Safety-optimized mRNA vaccination with a panel of 29 allergens

Elisabeth Roesler et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

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Article Oncology

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

Benjamin Weide et al.

JOURNAL OF IMMUNOTHERAPY (2009)

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Article Medicine, Research & Experimental

A novel immunotherapy to hepatocellular carcinoma: CD40-activated B lymphocytes transfected with AFPmRNA

Yafeng Wan et al.

MEDICAL HYPOTHESES (2009)

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Article Biotechnology & Applied Microbiology

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Katalin Kariko et al.

MOLECULAR THERAPY (2008)

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Article Immunology

Modification of CEA with both CRT and TAT PTD induces potent anti-tumor immune responses in RNA-pulsed DC vaccination

Sung-Guh Kim et al.

VACCINE (2008)

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Article Biochemistry & Molecular Biology

Role of poly (A) tail as an identity element for mRNA nuclear export

Hiroyuki Fuke et al.

NUCLEIC ACIDS RESEARCH (2008)

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Article Biochemistry & Molecular Biology

Improved native affinity purification of RNA

Robert T. Batey et al.

RNA (2007)

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Article Oncology

T cell responses in melanoma patients after vaccination with tumor-mRNA transfected dendritic cells

Jon Amund Kyte et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2007)

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Article Biotechnology & Applied Microbiology

Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA

J. A. Kyte et al.

CANCER GENE THERAPY (2006)

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Article Medical Laboratory Technology

Induction of cytotoxic T-lymphocyte responses using dendritic cells transfected with hepatocellular carcinoma mRNA

B-G. Peng et al.

BRITISH JOURNAL OF BIOMEDICAL SCIENCE (2006)

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Article Multidisciplinary Sciences

Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism

D Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Public, Environmental & Occupational Health

Washing our hands of the congenital cytomegalovirus disease epidemic

MJ Cannon et al.

BMC PUBLIC HEALTH (2005)

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Article Oncology

Evaluation of dendritic cells loaded with apoptotic cancer cells or expressing tumour mRNA as potential cancer vaccines against leukemia -: art. no. 20

S Jarnjak-Jankovic et al.

BMC CANCER (2005)

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Article Multidisciplinary Sciences

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

F Heil et al.

SCIENCE (2004)

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Article Oncology

Apoptotic tumor cells are superior to tumor cell lysate, and tumor cell RNA in induction of autologous T cell response in B-CLL

P Kokhaei et al.

LEUKEMIA (2004)

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Article Oncology

Tumor mRNA-loaded dendritic cells elicit tumor-specific CD8+ cytotoxic T cells in patients with malignant glioma

T Kobayashi et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2003)

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Article Chemistry, Organic

Synthesis and application of a chain-terminating dinucleotide mRNA cap analog

ZH Peng et al.

ORGANIC LETTERS (2002)

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