Journal
AGING-US
Volume 15, Issue 16, Pages 7909-7921Publisher
IMPACT JOURNALS LLC
Keywords
circadian rhythms; aging; RNA transcriptomics; pancreas
Categories
Ask authors/readers for more resources
The circadian control of pancreatic function may be influenced by aging. This study shows that the pancreatic transcriptome undergoes reorganization during aging, with the aged pancreas exhibiting gain of rhythms in extrinsic cellular pathways and potential involvement of fibroblast-associated mechanisms.
The evolutionarily conserved circadian system allows organisms to synchronize internal processes with 24-h cycling environmental timing cues, ensuring optimal adaptation. Like other organs, the pancreas function is under circadian control. Recent evidence suggests that aging by itself is associated with altered circadian homeostasis in different tissues which could affect the organ's resiliency to aging-related pathologies. Pancreas pathologies of either endocrine or exocrine components are age-related. Whether pancreas circadian transcriptome output is affected by age is still unknown. To address this, here we profiled the impact of age on the pancreatic transcriptome over a full circadian cycle and elucidated a circadian transcriptome reorganization of pancreas by aging. Our study highlights gain of rhythms in the extrinsic cellular pathways in the aged pancreas and extends a potential role to fibroblast-associated mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available