Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 21, Issue 9, Pages 2327-2338Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jtha.2023.06.007
Keywords
cell adhesion; endoglin; hemostasis; HHT; integrins; platelets; vascular homeostasis
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This study suggests that membrane-bound endoglin and circulating endoglin play important roles in vascular homeostasis and hemostasis.
Endoglin, alias CD105, is a human membrane glycoprotein highly expressed in vascular endothelial cells. It is involved in angiogenesis and angiogenesis-related diseases, including the rare vascular pathology known as hereditary hemorrhagic telangiectasia type 1. Although endoglin acts as an accessory receptor for members of the transforming growth factor-beta family, in recent years, emerging evidence has shown a novel functional role for this protein beyond the transforming growth factor-beta system. In fact, endoglin has been found to be an integrin counterreceptor involved in endothelial cell adhesion processes during pathological inflammatory conditions and primary hemostasis. Furthermore, a circulating form of endoglin, also named as soluble endoglin, whose levels are abnormally increased in different pathological conditions, such as preeclampsia, seems to act as an antagonist of membrane-bound endoglin and as a competitor of the fibrinogen-integrin interaction in platelet-dependent thrombus formation. These studies suggest that membrane-bound endoglin and circulating endoglin are important components involved in vascular homeostasis and hemostasis.
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