Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 21, Issue 38, Pages 7702-7706Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3ob01247f
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In this study, three model hydantoin-based universal peptidomimetics were designed, synthesized, and investigated for their antibacterial activities against Gram-positive and Gram-negative bacteria strains. The results demonstrated that these compounds could potentially serve as promising antibiotics to combat emerging drug resistance.
Three model hydantoin-based universal peptidomimetics were designed and synthetized. Their preferred amphiphilic beta-turn conformation was assessed using molecular modeling and NMR experiments, and their antibacterial activity was tested against Gram-positive and Gram-negative bacteria strains, which demonstrated that these compounds could be a captivating class of antibiotics to fight emergent drug resistance. Three model hydantoin-based universal peptidomimetics were designed, synthetized, and investigated as Gram positive and Gram negative antimicrobial agents.
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