☆ 4.7 Article

Xihuang pill ameliorates colitis in mice by improving mucosal barrier injury and inhibiting inflammatory cell filtration through network regulation

JOURNAL OF ETHNOPHARMACOLOGY (2024)

Related references

Note: Only part of the references are listed.

Article Plant Sciences

Systems biology strategy and experimental validation to uncover the pharmacological mechanism of Xihuang Pill in treating non-small cell lung cancer

Zhenjie Zhuang et al.

Summary: The present study aimed to investigate the pharmacological mechanisms involved in treating non-small cell lung cancer (NSCLC) with Xihuang Pill (XHP), a representative anticancer Chinese patented medicine. XHP was found to suppress cancer cell growth in NSCLC by regulating pathways associated with cell proliferation and immunity. In addition, XHP may increase the expression of CACNA1C to suppress immune cell infiltration and regulate the expression of checkpoint-related genes, thereby improving the overall survival of NSCLC patients.

PHYTOMEDICINE (2023)

Add to Collection

Article Plant Sciences

Xihuang pill in the treatment of cancer: TCM theories, pharmacological activities, chemical compounds and clinical applications

Hong-Bin Xu et al.

Summary: This study aims to summarize recent advances in research on the anti-cancer efficacies of Xihuang pill, a famous traditional Chinese formula, based on the theoretical basis of traditional Chinese medicine, pharmacological activities, chemical components, and clinical application. The study found that Xihuang pill exerts anti-cancer effects by inducing cancer cell apoptosis, inhibiting cell proliferation, migration, invasion, and angiogenesis, improving immune function and tumor microenvironment, and regulating related signaling pathways. Clinically, Xihuang pill, as an adjuvant drug in combination with chemotherapy, can prolong survival, enhance response rate, improve quality of life, regulate immune function, and alleviate chemotherapy-induced toxicities.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

Add to Collection

Review Pathology

Infectious Mimics of Inflammatory Bowel Disease

Nicole C. Panarelli

Summary: Distinguishing inflammatory bowel disease (IBD) from its mimics is challenging for surgical pathologists due to overlapping inflammatory patterns produced by several gastrointestinal infections. Clinical tests may not always be available or reflect ongoing infections. Therefore, surgical pathologists should be knowledgeable about infectious mimics of IBD to generate accurate diagnoses and guide clinical follow-up. This review focuses on bacterial, fungal, and protozoal infections in the differential diagnosis of IBD.

MODERN PATHOLOGY (2023)

Add to Collection

Review Gastroenterology & Hepatology

Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis

Juan S. Lasa et al.

Summary: This study compares the efficacy and safety of biologics and small molecule drugs for the treatment of moderate-to-severe ulcerative colitis. The findings show that Upadacitinib performs well in inducing clinical remission, while Vedolizumab performs best in terms of safety.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced Drosophila Ulcerative Colitis Model by Inhibiting the JNK Signaling

Tian Wei et al.

Summary: Ursolic acid (UA), a bioactive molecule found in fruits and vegetables, has therapeutic potential in ulcerative colitis (UC) induced by toxic chemicals. In this study, using a Drosophila UC model, the protective effect of UA on intestinal damage induced by sodium dodecyl sulfate (SDS) was investigated. The results showed that UA could protect against SDS-induced damage by reducing oxidative stress and restoring the activity of antioxidant enzymes. Additionally, UA inhibited the excessive activation of the JNK-dependent JAK/STAT signaling pathway. These findings suggest that UA has potential for the development of functional food or natural medicine for UC.

ANTIOXIDANTS (2022)

Add to Collection

Article Cell Biology

STING1 is essential for an RNA-virus triggered autophagy

Rui Zhang et al.

Summary: The study reveals that during foot-and-mouth disease virus (FMDV) infection, the integrated stress response in cells is initiated by the cellular pattern recognition receptor DDX58/RIG-I, which signals to the ER-anchored adaptor protein STING1. This activation leads to reticulophagy and degradation of STING1, which is essential for FMDV genome replication and viral protein expression.

AUTOPHAGY (2022)

Add to Collection

Review Immunology

The influence of cytokines on the complex pathology of ulcerative colitis

Hiroshi Nakase et al.

Summary: Ulcerative colitis (UC) is specifically affected by genetic alterations, environmental factors, microbiota, and mucosal immune dysregulation, leading to a lack of response in 30%-55% of patients to current therapies. The expression levels of cytokines associated with treatment depend on disease stage and patient characteristics, suggesting that future targeted therapies should focus on these differences and individual cytokine profiles.

AUTOIMMUNITY REVIEWS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro

Rongfu Tu et al.

Summary: The study reveals that USP49 promotes the survival of colorectal cancer cells by stabilizing BAG2 and may become a potential therapeutic target for CRC.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Add to Collection

Article Gastroenterology & Hepatology

Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management

Shailja C. Shah et al.

Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Chronic inflammation plays a key role in the development of neoplastic progression, resulting in dysplastic precursor lesions. Colitis-associated CRC shares molecular similarities with sporadic CRC and the microbiome and host immune system may also play a role. However, further research is needed to understand the specific molecular differences and their role in inflammation-associated cancers.

GASTROENTEROLOGY (2022)

Add to Collection

Article Endocrinology & Metabolism

Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice

Shuiping Liu et al.

Summary: Melatonin (MT) pretreatment alleviates AFB1-induced liver injury by regulating gut microbiota/intestinal FXR/liver TLR4 signaling axis.

JOURNAL OF PINEAL RESEARCH (2022)

Add to Collection

Article Medicine, Research & Experimental

Xihuang Pill enhances anticancer effect of anlotinib by regulating gut microbiota composition and tumor angiogenesis pathway

Bo Cao et al.

Summary: Lung cancer is a serious threat to human health. Combination therapy of XHW and anlotinib significantly inhibits tumor growth in lung cancer mice models. XHW enhances the anticancer effect of anlotinib by regulating gut microbiota composition and tumor angiogenesis pathway.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Article Gastroenterology & Hepatology

Safety and efficacy of long-term tofacitinib treatment in East Asian patients with ulcerative colitis in OCTAVE Open

Katsuyoshi Matsuoka et al.

Summary: This study presents safety and efficacy data of tofacitinib for the treatment of ulcerative colitis in East Asian patients. The results show that the safety and efficacy of tofacitinib are consistent with the global study population, although the occurrence rate of herpes zoster is slightly higher in East Asian patients.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Mannose ameliorates experimental colitis by protecting intestinal barrier integrity

Lijun Dong et al.

Summary: The study shows that mannose supplementation can alleviate symptoms of inflammatory bowel disease, including colitis. It improves intestinal barrier integrity, reduces the release of proteins, and prevents mitochondrial dysfunction. Mannose also synergizes with the conventional drug mesalamine in colitis treatment.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Cell Biology

ENO2 Promotes Colorectal Cancer Metastasis by Interacting with the LncRNA CYTOR and Activating YAP1-Induced EMT

Chunwei Lv et al.

Summary: This study found that upregulation of the glycolytic enzyme enolase 2 (ENO2) in colorectal cancer (CRC) samples was negatively associated with prognosis. Furthermore, the study showed that ENO2 promotes CRC cell migration and invasion through its interaction with the long noncoding RNA (lncRNA) CYTOR. CYTOR mediates the binding of ENO2 to large tumor suppressor 1 (LATS1) and competitively inhibits the phosphorylation of Yes-associated protein 1 (YAP1), ultimately triggering epithelial-mesenchymal transition (EMT).

CELLS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Pioglitazone Attenuates the Effects of Peripheral Inflammation in a Human In Vitro Blood-Brain Barrier Model

Gustavo Henrique Oliveira da Rocha et al.

Summary: This study investigated the effects of plasma from inflammatory bowel disease (IBD) patients and tumor necrosis factor alpha (TNF alpha) on the blood-brain barrier (BBB), as well as the anti-inflammatory role of pioglitazone. The results showed that TNF alpha increased BBB permeability, while pioglitazone attenuated these effects. Plasma from IBD patients also increased BBB permeability, which was reversed by pioglitazone. These findings demonstrate the potential of pioglitazone in controlling peripheral BBB inflammation associated with inflammatory conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Gastroenterology & Hepatology

Impact of Bowel Urgency on Quality of Life and Clinical Outcomes in Patients With Ulcerative Colitis

Marla C. Dubinsky et al.

Summary: The absence of bowel urgency is strongly associated with improved quality of life, clinical outcomes, and reduced levels of inflammatory biomarkers in patients with ulcerative colitis.

CROHNS & COLITIS 360 (2022)

Add to Collection

Article Integrative & Complementary Medicine

Research Advances in Protective Effects of Ursolic Acid and Oleanolic Acid Against Gastrointestinal Diseases

Yajing Shi et al.

Summary: The intestinal tract plays a crucial role in protecting tissues from external harmful substances, but damage to the intestinal barrier can lead to systemic complications. Research indicates that ursolic acid and oleanolic acid can alleviate intestinal pathological injury and restore intestinal barrier function.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Add to Collection

Article Oncology

Cyclosporine modulates neutrophil functions via the SIRT6-HIF-1α-glycolysis axis to alleviate severe ulcerative colitis

Huiying Lu et al.

Summary: The study revealed that CsA alleviates ASUC by promoting neutrophil HIF-1 alpha expression and restricting excessive neutrophil activation in a SIRT6-HIF-1 alpha-glycolysis axis, suggesting SIRT6 as a candidate target for maintaining mucosal homeostasis and treating intestinal inflammation.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Chemistry, Applied

Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon

Cuiling Guo et al.

Summary: The study found that GLP can reduce AOM/DSS-induced colitis and tumorigenesis, improve dysbiosis, increase short-chain fatty acid production, and enhance gut barrier function.

CARBOHYDRATE POLYMERS (2021)

Add to Collection

Article Immunology

Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells

Liraz Shmuel-Galia et al.

Summary: Alterations in the cGAS-STING DNA-sensing pathway can affect intestinal homeostasis and lead to inflammation. Increased STING expression is a feature of intestinal inflammation in both mice with colitis and humans with inflammatory bowel disease. STING accumulation in intestinal myeloid cells can be triggered by dysbiosis and bacterial products, leading to a positive feedback loop that drives intestinal inflammation.

IMMUNITY (2021)

Add to Collection

Review Pharmacology & Pharmacy

Neutrophil extracellular traps in inflammatory bowel diseases: Implications in pathogenesis and therapeutic targets

Anderson dos Santos Ramos et al.

Summary: Neutrophils, particularly their ability to form extracellular traps (NETs), play a significant role in the pathophysiology of inflammatory bowel disease (IBD). Studies have shown increased levels of NETs in tissue and serum samples from IBD patients, indicating their involvement in disease progression. This highlights the potential of targeting NETs as a therapeutic strategy to expand the current spectrum of IBD therapies.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection

Article Multidisciplinary Sciences

Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease

Debashis Sahoo et al.

Summary: Modeling human diseases as networks and utilizing machine learning successfully predicted outcomes and identified a novel therapy for inflammatory bowel disease, improving the integrity of the gut epithelial barrier.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Oncology

Metastasis Risk Assessment Using BAG2 Expression by Cancer-Associated Fibroblast and Tumor Cells in Patients with Breast Cancer

Chang-Ik Yoon et al.

Summary: The study found that the expression of BAG2 in cancer-associated fibroblasts (CAFs) and tumor cells is closely associated with distant metastasis-free survival in breast cancer patients, and evaluating this expression can help determine the risk of metastasis.

CANCERS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

A diet based on cured acorn-fed ham with oleic acid content promotes anti-inflammatory gut microbiota and prevents ulcerative colitis in an animal model

J. Fernandez et al.

LIPIDS IN HEALTH AND DISEASE (2020)

Add to Collection

Article Nutrition & Dietetics

Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation

Marica Cariello et al.

NUTRIENTS (2020)

Add to Collection

Article Medicine, Research & Experimental

Modulatory effects of Xihuang Pill on lung cancer treatment by an integrative approach

Chunyu Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Article Medicine, General & Internal

Ulcerative colitis

Taku Kobayashi et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer

Yan Zheng et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Article Cell Biology

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion

Yu Xia et al.

AUTOPHAGY (2019)

Add to Collection

Article Microbiology

Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways

Melinda A. Engevik et al.

MBIO (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis

Eleonora Cremonini et al.

REDOX BIOLOGY (2019)

Add to Collection

Article Medicine, Research & Experimental

Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway

Liang Su et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Article Nutrition & Dietetics

Small Intestinal Permeability and Gut-Transit Time Determined with Low and High Molecular Weight Fluorescein Isothiocyanate-Dextrans in C3H Mice

Anni Woting et al.

NUTRIENTS (2018)

Add to Collection

Article Integrative & Complementary Medicine

Clinical Effects of Xihuang Pill Combined with Chemotherapy in Patients with Advanced Colorectal Cancer

Dan Yu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

Add to Collection

Article Multidisciplinary Sciences

INNATE IMMUNITY A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

George M. H. Birchenough et al.

SCIENCE (2016)

Add to Collection

Review Integrative & Complementary Medicine

Review on the Applications and Molecular Mechanisms of Xihuang Pill in Tumor Treatment

Qiujun Guo et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

Add to Collection

Review Gastroenterology & Hepatology

Current and Emerging Biologics for Ulcerative Colitis

Sung Chul Park et al.

GUT AND LIVER (2015)

Add to Collection

Article Immunology

Oleanolic acid ameliorates dextran sodium sulfate-induced colitis in mice by restoring the balance of Th17/Treg cells and inhibiting NF-κB signaling pathway

Geum-Dan Kang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2015)

Add to Collection

Article Multidisciplinary Sciences

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Sergei I. Grivennikov et al.

NATURE (2012)

Add to Collection

Article Medicine, Research & Experimental

Xanthorrhizol attenuates dextran sulfate sodium-induced colitis via the modulation of the expression of inflammatory genes in mice

Jae Young Cho et al.

LIFE SCIENCES (2011)

Add to Collection

Article Biochemistry & Molecular Biology

Nitrated oleic acid up-regulates PPARγ and attenuates experimental inflammatory bowel disease

Sara Borniquel et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Add to Collection

Article Gastroenterology & Hepatology

Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis

C. Anthoni et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Add to Collection

© Peeref 2019-2024. All rights reserved.