4.4 Review

Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Mechanisms of cardiac dysfunction in diabetic cardiomyopathy: molecular abnormalities and phenotypical variants

Francesca Romana Prandi et al.

Summary: Diabetic cardiomyopathy is a diabetes-induced condition that leads to changes in cardiac structure, function, and metabolism, potentially causing heart failure. Metabolic alterations and cellular molecular mechanisms play crucial roles in its development. Further research is needed to understand the underlying mechanisms and identify therapeutic targets for preventing and reversing heart failure in diabetic patients.

HEART FAILURE REVIEWS (2023)

Article Cardiac & Cardiovascular Systems

Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system

Elmir Omerovic et al.

Summary: This scientific statement from the Heart Failure Association (HFA) of the European Society of Cardiology focuses on the pathophysiology of Takotsubo syndrome. It provides an overview of the disease and discusses the role of catecholamines and the sympathetic nervous system, as well as their direct effects on myocardial biology. The statement also explores the integrated effects on ventricular haemodynamics.

EUROPEAN JOURNAL OF HEART FAILURE (2022)

Review Andrology

The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes

Teresa Vezza et al.

Summary: This review explores the molecular mechanisms of mitochondrial fusion and fission processes, their role in type 2 diabetes, and the therapeutic potential of targeting mitochondrial dynamics in this complex metabolic disorder.

WORLD JOURNAL OF MENS HEALTH (2022)

Article Peripheral Vascular Disease

Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance

Danan Sun et al.

Summary: Coronary microvascular endothelial dysfunction in diabetes is a complex pathological process involving mitochondrial function, dynamics, and autophagy. Abnormalities in the mitochondrial quality surveillance system may lead to the accumulation of unhealthy mitochondria and activation of apoptosis, accelerating the progression of coronary microvascular complications.

ANGIOGENESIS (2022)

Article Nutrition & Dietetics

Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis

Sabine Kleissl-Muir et al.

Summary: Diabetic cardiomyopathy (DMCM) is associated with elevated blood glucose levels, insulin resistance, and hyperinsulinemia. Low carbohydrate diets may improve insulin resistance and glycemic control, leading to improvements in cardiovascular function in patients with DMCM.

FRONTIERS IN NUTRITION (2022)

Review Biochemistry & Molecular Biology

Metabolic Remodeling and Implicated Calcium and Signal Transduction Pathways in the Pathogenesis of Heart Failure

Antoine H. Chaanine

Summary: Mitochondria in the heart, especially the intermyofibrillar mitochondria, play a crucial role in cellular metabolism and signaling, regulating ATP production. These mitochondria are closely linked to the endoplasmic reticulum, enabling efficient calcium signaling and maintaining mitochondrial function. Perturbations in this ER-mitochondrial crosstalk can lead to dysregulation of calcium homeostasis and mitochondrial function, contributing to the pathogenesis of heart failure.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cardiac & Cardiovascular Systems

Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death

Priya Umapathi et al.

Summary: Excessive O-GlcNAcylation contributes to cardiomyopathy, at least in part, due to defective energetics. Enhanced OGA activity is well tolerated, and attenuation of O-GlcNAcylation is beneficial against pressure overload-induced pathologic remodeling and heart failure.

CIRCULATION (2021)

Article Endocrinology & Metabolism

Relationships between inflammation, hemodynamic function and RAAS in longstanding type 1 diabetes and diabetic kidney disease

Jaya Prakash Nath Ambinathan et al.

Summary: The study found that individuals with long standing type 1 diabetes had lower urinary excretion of certain inflammatory biomarkers compared to controls, while DKD patients had higher levels of IL-6 in their urine. In T1D, lower GFR levels correlated with greater excretion of proinflammatory biomarkers, growth factors, and chemokines.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2021)

Review Pharmacology & Pharmacy

Hyperkalemia with RAAS inhibition: Mechanism, clinical significance, and management

Gregory L. Hundemer et al.

Summary: RAAS inhibitors are evidence-based treatments for various conditions, but can lead to hyperkalemia, which increases the risk for cardiovascular events. Managing hyperkalemia while maintaining the benefits of RAAS inhibitors is essential to prevent adverse outcomes.

PHARMACOLOGICAL RESEARCH (2021)

Review Cardiac & Cardiovascular Systems

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases

Jun Ren et al.

Summary: This review summarizes the role of endoplasmic reticulum stress and protein response in cardiovascular diseases, discussing potential therapeutic strategies for restoring ER proteostasis.

NATURE REVIEWS CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Cardiac Energy Metabolism in Heart Failure

Gary D. Lopaschuk et al.

Summary: Changes in cardiac energy metabolism are complex and depend on the severity and type of heart failure, as well as the presence of common comorbidities such as obesity and type 2 diabetes. The failing heart experiences an energy deficit due to decreased mitochondrial oxidative capacity, compensated for by increased ATP production from glycolysis. Alterations in mitochondrial ATP production fuels and fatty acid oxidation contribute to the inefficiency of the failing heart, with potential therapeutic targets in energy metabolic pathways to improve cardiac function.

CIRCULATION RESEARCH (2021)

Correction Endocrinology & Metabolism

Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes (vol 45, pg 146, 2021)

Jin Joo Park

DIABETES & METABOLISM JOURNAL (2021)

Review Endocrinology & Metabolism

Cardiac autonomic neuropathy and risk of cardiovascular disease and mortality in type 1 and type 2 diabetes: a meta-analysis

Mahin Chowdhury et al.

Summary: This study identified a significant prognostic association between cardiac autonomic neuropathy (CAN) and cardiovascular disease events (CVE) and mortality in type 1 and type 2 diabetes through a systematic review and meta-analysis. Implementing population-based CAN screening can help identify a subgroup with disproportionately higher cardiovascular and mortality risk, allowing for earlier targeted interventions.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

Review Cardiac & Cardiovascular Systems

SGLT-2 Inhibitors in Heart Failure: Guide for Prescribing and Future Perspectives

Vishnu Vardhan Garla et al.

Summary: SGLT-2 inhibitors have demonstrated significant benefits in reducing mortality and hospitalization rates associated with heart failure, with clinical trials showing positive outcomes. Guidelines recommend their preferential use for patients with a history of cardiovascular disease, highlighting their potential as game changers in heart failure treatment.

CURRENT CARDIOLOGY REPORTS (2021)

Review Endocrinology & Metabolism

Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes

Jin Joo Park

Summary: Diabetes increases the risk of cardiovascular disease by affecting vascular homeostasis and myocardial function. Prognosis is worse in heart failure patients with diabetes compared to those without diabetes.

DIABETES & METABOLISM JOURNAL (2021)

Review Cell Biology

Chronic low-grade inflammation in heart failure with preserved ejection fraction

Thassio Mesquita et al.

Summary: HFpEF is the predominant form of heart failure with a significant increase in risk with age. Low-grade inflammation, termed inflammaging, is a common feature of HFpEF pathology. Suppression of proinflammatory pathways has been associated with attenuated disease severity and improved outcomes in HFpEF. Inflammasome signaling plays a central role in mediating chronic inflammation and cardiovascular disease progression.

AGING CELL (2021)

Article Endocrinology & Metabolism

Cohort profile: National Diabetes Audit for England and Wales

Naomi Holman et al.

Summary: The National Diabetes Audit collects and analyzes data on the quality of care and outcomes for people with diabetes, providing valuable information for clinical and public health priorities; By March 31, 2020, over 5 million people diagnosed with diabetes had participated in NDA data collection, offering insights into disease trends and outcomes.

DIABETIC MEDICINE (2021)

Article Endocrinology & Metabolism

Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study

Symen Ligthart et al.

Summary: Genetic variants play a role in estimating the lifetime risk of type 2 diabetes while normal weight helps partially offset the adverse effects of high genetic risk.

DIABETIC MEDICINE (2021)

Review Cardiac & Cardiovascular Systems

PPAR control of metabolism and cardiovascular functions

David Montaigne et al.

Summary: Novel PPAR agonists offer new opportunities for managing metabolic and cardiovascular diseases by regulating gene expression, lipid metabolism, insulin sensitivity, glucose metabolism, and cardiovascular health. Activation of PPARs by specific ligands can have antiatherogenic, anti-inflammatory, and metabolic benefits, making them important therapeutic targets in the treatment of various diseases.

NATURE REVIEWS CARDIOLOGY (2021)

Review Physiology

Oxidative Stress, Kinase Activation, and Inflammatory Pathways Involved in Effects on Smooth Muscle Cells During Pulmonary Artery Hypertension Under Hypobaric Hypoxia Exposure

Patricia Siques et al.

Summary: High-altitude exposure leads to hypobaric hypoxia, affecting pulmonary artery smooth muscle cells through oxidative stress, inflammation, and kinase activation, ultimately contributing to the development of high-altitude pulmonary hypertension.

FRONTIERS IN PHYSIOLOGY (2021)

Article Urology & Nephrology

SGLT2 Inhibitors: Physiology and Pharmacology

Ernest M. Wright

Summary: SGLTs are glucose transporters found on the luminal membrane of the proximal tubule, and SGLT2 inhibitors can reduce glucose reabsorption, lower blood sugar levels, and protect heart and kidney function in patients with type 2 diabetes mellitus.

KIDNEY360 (2021)

Article Cardiac & Cardiovascular Systems

Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure

Senthil Selvaraj et al.

CIRCULATION (2020)

Review Cardiac & Cardiovascular Systems

Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities

Ilona Cuijpers et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure

Anis Hanna et al.

CARDIOVASCULAR DRUGS AND THERAPY (2020)

Review Biochemistry & Molecular Biology

Oxidative Stress, Kinase Activity and Inflammatory Implications in Right Ventricular Hypertrophy and Heart Failure under Hypobaric Hypoxia

Eduardo Pena et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, Research & Experimental

Empagliflozin ameliorates ethanol-induced liver injury by modulating NF-cB/Nrf-2/PPAR-γ interplay in mice

Amir Mohamed Abdelhamid et al.

LIFE SCIENCES (2020)

Article Multidisciplinary Sciences

Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function

Brooke C. Wilson et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications

Aitor Almanza et al.

FEBS JOURNAL (2019)

Editorial Material Cardiac & Cardiovascular Systems

Diabetic Cardiomyopathy What Is It and Can It Be Fixed?

Wolfgang H. Dillmann

CIRCULATION RESEARCH (2019)

Review Biochemistry & Molecular Biology

ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy

Simona Gallo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cardiac & Cardiovascular Systems

70-year legacy of the Framingham Heart Study

Charlotte Andersson et al.

NATURE REVIEWS CARDIOLOGY (2019)

Article Cardiac & Cardiovascular Systems

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure

Mariya Kronlage et al.

CIRCULATION (2019)

Review Chemistry, Medicinal

Mechanisms of Protective Effects of SGLT2 Inhibitors in Cardiovascular Disease and Renal Dysfunction

Ban Liu et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)

Article Pharmacology & Pharmacy

Carvacrol Attenuates Diabetic Cardiomyopathy by Modulating the PI3K/AKT/GLUT4 Pathway in Diabetic Mice

Ning Hou et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Treating oxidative stress in heart failure: past, present and future

Atze van der Pol et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

Review Multidisciplinary Sciences

Structure and function of the insulin receptor-a personal perspective

Masato Kasuga

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2019)

Article Cardiac & Cardiovascular Systems

Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis

Lindsay T. McDonald et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Cardiovascular Effects of New Oral Glucose-Lowering Agents DPP-4 and SGLT-2 Inhibitors

Andre J. Scheen

CIRCULATION RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity

Guanghong Jia et al.

CIRCULATION RESEARCH (2018)

Article Anesthesiology

Nutritional ketosis delays the onset of isoflurane induced anesthesia

Csilla Ari et al.

BMC ANESTHESIOLOGY (2018)

Review Biochemistry & Molecular Biology

The PI3K/AKT pathway in obesity and type 2 diabetes

Xingjun Huang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Review Medicine, Research & Experimental

Mitochondrial dysfunction in pathophysiology of heart failure

Bo Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Medicine, General & Internal

Risk Factors, Mortality, and Cardiovascular Outcomes in Patients with Type 2 Diabetes

Aidin Rawshani et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Food Science & Technology

Uremia Impacts VE-Cadherin and ZO-1 Expression in Human Endothelial Cell-to-Cell Junctions

Rayana A. P. Maciel et al.

TOXINS (2018)

Review Endocrinology & Metabolism

Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease

Guanghong Jia et al.

DIABETOLOGIA (2018)

Article Endocrinology & Metabolism

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling

Mingming Zhang et al.

JOURNAL OF PINEAL RESEARCH (2017)

Review Medicine, General & Internal

Ketogenic diet in endocrine disorders: Current perspectives

L. Gupta et al.

JOURNAL OF POSTGRADUATE MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Atrial Fibrillation and Arterial Hypertension: Gender Differences of Ventriculoatrial Remodeling with Preserved Ejection Fraction

Zhanna D. Kobalava et al.

RATIONAL PHARMACOTHERAPY IN CARDIOLOGY (2017)

Article Medicine, General & Internal

Diabetes Mellitus and Heart Failure

Michael Lehrke et al.

AMERICAN JOURNAL OF MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure

Shun-Guang Wei et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Chronic Heart Failure and Inflammation What Do We Really Know?

Sarah A. Dick et al.

CIRCULATION RESEARCH (2016)

Review Medicine, Research & Experimental

Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis

Mostafa Samak et al.

MEDICAL SCIENCE MONITOR BASIC RESEARCH (2016)

Review Cardiac & Cardiovascular Systems

Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes

Stephen C. Kolwicz et al.

CIRCULATION RESEARCH (2013)

Article Cardiac & Cardiovascular Systems

Oxidative Stress, Nox Isoforms and Complications of Diabetes-Potential Targets for Novel Therapies

Mona Sedeek et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2012)

Review Cardiac & Cardiovascular Systems

Coronary artery calcium and cardiovascular risk in diabetes

R. S. Elkeles

ATHEROSCLEROSIS (2010)

Review Cardiac & Cardiovascular Systems

Mitochondria in the diabetic heart

Heiko Bugger et al.

CARDIOVASCULAR RESEARCH (2010)

Review Cell Biology

Angiotensin II and the development of insulin resistance: Implications for diabetes

J. Alberto Olivares-Reyes et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)

Article Biochemistry & Molecular Biology

Mitochondrial creatine kinase: Properties and function

TY Lipskaya

BIOCHEMISTRY-MOSCOW (2001)