Influence of TDN on conventional aptasensors

Article Chemistry, Analytical

Dual-detection of miRNAs in living cells via hybridization chain reaction on DNA tetrahedron

Liuting Mo et al.

Summary: In this study, a 3D hybridization chain reaction (HCR) on a binary DNA tetrahedron (DTN) system was used for multiplexed detection of miR-21 and miR-203, enabling accurate, sensitive, and rapid analysis of intracellular miRNA levels.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Chemistry, Analytical

Fluorescent/electrochemical dual-signal response biosensing strategy mediated by DNAzyme-ferrocene-triggered click chemistry for simultaneous rapid screening and quantitative detection of Vibrio parahaemolyticus

Shuai Wang et al.

Summary: To ensure food safety, rapid screening and quantitative detection of foodborne pathogens are essential. This study developed a dual-signal response biosensing strategy that combines visual fluorescent signal and quantitative electrochemical signal for simultaneous detection. A signal probe consisting of deoxyribozyme (DNAzyme)-ferrocene immobilized on MXene/gold nanobipyramid/antimicrobial peptide was used. The DNAzyme enabled a click reaction to produce visual fluorescent signal, while ferrocene provided an electrochemical detection signal to confirm foodborne pathogen contamination. This dual-signal biosensing strategy exhibited a wide detectable range and low detection limit, making it a useful tool for on-site detection of foodborne pathogens.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Chemistry, Analytical

Electrochemiluminescence sensor based on graphdiyne quantum dots functionalized MOF-derived ZnO with self-enhancing effect for the detection of radical scavenging drugs

Yu Lin et al.

Summary: Graphdiyne oxide quantum dots (GDYO QDs) with active acetylene units show excellent biological activity. MOF-derived ZnO (M-ZnO) enhances the capacity of GDYO QDs and promotes co-reactions. The ECL intensity of GDYO QDs @M-ZnO modified electrode is significantly higher compared to GDYO QDs alone. The ECL sensor constructed using GDYO QDs @M-ZnO detects radical scavenging drugs with good sensitivities, specificities, reproducibilities, and stabilities.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Chemistry, Analytical

A colorimetric biosensor to track Trop-2 status of tumor cells for diagnosis of breast cancer

Tianyu Zeng et al.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Chemistry, Analytical

A potential-resolved ratiometric electrochemiluminescence aptasensor for Pb2+: Gold nanoclusters and amino-terminated perylene derivative as both emitters and resonance energy transfer donor-acceptor pair

Panao Jiang et al.

Summary: Finding a pair of electrochemiluminescence emitters that can act as both energy donor and acceptor simultaneously is crucial for the development of ratiometric ECL aptasensors based on ECL resonance energy transfer strategy (ECL-RET). In this study, aggregation-induced emission gold nanoclusters (AuNCs) and amino-terminated perylene derivative (PTC-NH2) with broad absorption range were combined as a novel ECL-RET donor-acceptor pair. By measuring the ratio of AuNCs and PTC-NH2 ECL intensities, a potential-resolved ratiometric ECL aptasensor for detecting lead ions (Pb2+) was successfully developed with low detection limit and excellent selectivity. The proposed aptasensor demonstrated favorable feasibility for Pb2+ assays in soil samples.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Chemistry, Analytical

Sandwich-type electrochemical aptasensor based on polydopamine-Au-metal ions as signal label and coralloid Au-conductive carbon architecture-modified electrode for the simultaneous detection of cardiac troponin I and myoglobin

Kaicha Chen et al.

Summary: A sandwich-type electrochemical aptasensor was constructed for the simultaneous detection of cardiac troponin I (cTnI) and myoglobin (Myo). The aptasensor demonstrated excellent performance in clinical diagnosis of acute myocardial infarction. The results showed wide linear ranges and low detection limits, indicating the potential application of the aptasensor.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Chemistry, Multidisciplinary

Metallointercalators-DNA Tetrahedron Supramolecular Self-Assemblies with Increased Serum Stability

M. Andrey Joaqui-Joaqui et al.

Summary: Self-assembly of metallointercalators into DNA nanocages can synthesize bioinorganic structures with high stability and cell penetration, making them suitable as metallodrugs.

ACS NANO (2022)

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Article Biochemical Research Methods

Ultrasensitive fluorescent detection of telomerase activity based on tetrahedral DNA nanostructures as carriers for DNA-templated silver nanoclusters

Wenting Cheng et al.

Summary: This study presents a tetrahedral DNA nanostructure combined with fluorescence signal amplification of DNA-templated silver nanoclusters for accurate detection of telomerase activity. By introducing single-strand extension of telomerase, the fluorescence of silver nanoclusters can be quickly activated, achieving a low detection limit of 1 cell.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)

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Article Biophysics

Catalytic hairpin assembled polymeric tetrahedral DNA frameworks for MicroRNA imaging in live cells

Yao Wang et al.

Summary: The study developed a method for imaging cellular miR-155 through the assembly of DNA frameworks driven by miR-155, leading to successful detection and imaging of miR-155 in live cells. The method significantly enhanced resistance to nuclease digestion and stable ability with exclusive interference.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

Multi-armed tetrahedral DNA probes for visualizing the whole-course of cell apoptosis by simultaneously fluorescence imaging intracellular cytochrome c and telomerase

Chen Dong et al.

Summary: Visualization of cell apoptosis is important for early disease diagnosis and understanding pathogenic mechanisms. A novel tetrahedral DNA probe is proposed to accurately visualize both early and late stages of cell apoptosis, with highly temporal and spatial consistency. The probe shows good sensitivity, selectivity, stability, and biocompatibility, making it a potential tool for studying apoptosis regulation and screening apoptosis-based drugs.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Nanoscience & Nanotechnology

Co-delivery of Chemotherapeutic Drugs and Immune Adjuvants by Nanoscale DNA Tetrahedrons for Synergistic Cancer Therapy

Qian Wang et al.

Summary: DNA nanostructures are used as drug delivery systems to achieve synergistic therapeutic effects in chemoimmunotherapy, showing excellent biocompatibility and superior treatment efficacy.

ACS APPLIED NANO MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Simultaneous Imaging of Dual microRNAs in Cancer Cells through Catalytic Hairpin Assembly on a DNA Tetrahedron

Chun Hong Li et al.

Summary: Simultaneous detection and imaging of two miRNAs was achieved using a DTN probe, showing great potential for improving detection accuracy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Analytical

DNA Logic Nanodevices for the Sequential Imaging of Cancer Markers through Localized Catalytic Hairpin Assembly Reaction

Li Li Li et al.

Summary: A DNA nanodevice with logic-responsive and signal amplifying capability has been developed for sequential imaging of tumor biomarkers in cells. The nanodevice shows better molecular targeting and recognition ability, making it useful for early cancer diagnosis and cell identification.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Tetrahedral DNA Supported Walking Nanomachine for Ultrasensitive miRNA Detection in Cancer Cells and Serums

Hua Chai et al.

Summary: Ultra-sensitive electrochemical analysis of miRNA is achieved through the construction of a three-dimensional DNA tetrahedral nanostructure, and successfully applied for the detection of miRNA in cell and serum samples.

ANALYTICAL CHEMISTRY (2022)

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Article Agriculture, Multidisciplinary

Fluorescence Resonance Energy Transfer Aptasensor of Ochratoxin A Constructed Based on Gold Nanorods and DNA Tetrahedrons

Liling Hao et al.

Summary: This study proposes a simple and novel strategy to improve the sensitivity of FRET aptasensors by using DNA tetrahedron and gold nanorods. The method exhibits linear detection sensitivity in the concentration range of 0.01-10 ng/mL, with a limit of detection of 0.005 ng/mL. The developed biosensor demonstrates efficient specificity, good accuracy and stability, and performs well in real samples.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Metal-Organic Framework UiO-66-Mediated Dual-Signal Ratiometric Electrochemical Sensor for microRNA Detection with DNA Walker Amplification

Fa-Ting Xie et al.

Summary: In this paper, an ultrasensitive ratiometric electrochemical biosensor was developed for the detection of miRNA using a DNA-walker mechanism and Zr MOF (UiO-66) signal tags. The biosensor exhibited high sensitivity, selectivity, and reproducibility, and could eliminate environmental disturbances and provide accurate signals.

LANGMUIR (2022)

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Article Chemistry, Analytical

Fully integrated FET-type gas sensor with optimized signal-to-noise ratio for H2S gas detection

Wonjun Shin et al.

Summary: This study proposes a novel gas sensing amplifier circuit composed of resistor-and FET-type gas sensors. The amplifier circuit utilizes Indium-gallium-zinc oxide (IGZO) as a sensing material for detecting hydrogen sulfide (H2S) gas. The low-frequency noise characteristics of the sensors are analyzed, and the signal-to-noise ratio and limit of detection of the amplifier circuit are determined. This methodology can contribute to the advancement of integrated gas sensing systems.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Nanoscience & Nanotechnology

MOF-Based Dual Sensor for the Electrochemical and Fluorescence Detection of Nicotine

T. Leeasree et al.

Summary: A dual sensor based on metal-organic frameworks has been developed for highly selective detection of nicotine. The sensor can efficiently detect nicotine using fluorescence and electrochemical sensing technique with a low detection limit, and shows high selectivity towards other interfering analytes.

ACS APPLIED NANO MATERIALS (2022)

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Article Nanoscience & Nanotechnology

DNA Tetrahedron-Based MNAzyme for Sensitive Detection of microRNA with Elemental Tagging

Shaocheng Liu et al.

Summary: A novel multicomponent nucleic acid enzyme system based on magnetic beads was designed for highly sensitive quantification of miRNA-155 by ICP-MS. Improvements in detection sensitivity and signal-to-noise ratio were achieved by carefully designing functionalized magnetic beads and gold nanoparticle probes.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Rapid SARS-CoV-2 Nucleic Acid Testing and Pooled Assay by Tetrahedral DNA Nanostructure Transistor

Xuejun Wang et al.

Summary: The TDN-LG FETs technology enables fast and frequent direct SARS-CoV-2 nucleic acid testing without the need for nucleic acid extraction and amplification, while also achieving unamplified 10-in-1 pooled nucleic acid testing with results consistent with PCR.

NANO LETTERS (2021)

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Article Nanoscience & Nanotechnology

Aptamer-Pendant DNA Tetrahedron Nanostructure Probe for Ultrasensitive Detection of Tetracycline by Coupling Target-Triggered Rolling Circle Amplification

Chengyi Hong et al.

Summary: The study developed a highly selective and sensitive method for detecting TET, applicable for TET determination in animal-derived foods, with results consistent with commercial ELISA kits.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Analytical

Electrochemiluminescence Biosensor Based on Entropy-Driven Amplification and a Tetrahedral DNA Nanostructure for miRNA-133a Detection

Linying Yu et al.

Summary: An electrochemiluminescence biosensor based on ETSD and TDN was developed for the rapid detection of the AMI biomarker microRNA-133a, showing a good linear response range and detection limit.

ANALYTICAL CHEMISTRY (2021)

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Article Nanoscience & Nanotechnology

An Aptamer-Modified DNA Tetrahedron-Based Nanogel for Combined Chemo/Gene Therapy of Multidrug-Resistant Tumors

Wantao Tang et al.

Summary: DNA-based nanogels have been used as a platform for combined chemo/gene therapy of multidrug-resistant tumors in this study, showing efficient targeted cellular internalization and stimuli-responsive release. The incorporation of aptamer and disulfide bridges in the design of DNA-based nanogels enables targeted drug delivery and combined tumor therapy, providing a new strategy for intelligent drug delivery.

ACS APPLIED BIO MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Tetrahedral DNA Nanostructures Inhibit Ferroptosis and Apoptosis in Cisplatin-induced Renal Injury

Jiaying Li et al.

Summary: This study demonstrated that tetrahedral DNA nanostructures (TDNs) can protect renal tubular cells from cisplatin-induced damage through multiple pathways, providing a reliable approach for treating acute kidney injury.

ACS APPLIED BIO MATERIALS (2021)

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Article Nanoscience & Nanotechnology