4.7 Article

High-resolution neuraminidase inhibition profiling of Arnebia euchroma (Royle) IM Johnst. based on HR-MS and target isolation: An example study of anti-infectious constituents in traditional Chinese medicine

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Antivirals Targeting the Neuraminidase

Larisa Gubareva et al.

Summary: The neuraminidase (NA) of influenza A and B viruses plays a crucial role in viral replication. Several NA inhibitors have been developed to treat influenza infections, but the emergence of drug resistance highlights the need for new antiviral strategies targeting NA.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2022)

Article Medicine, Research & Experimental

Emerging HxNy Influenza A Viruses

William J. Liu et al.

Summary: This study summarizes and discusses the characteristics of different subtypes of influenza viruses in various hosts, as well as the key molecular features of emerging infectious influenza viruses. This enhances our understanding of the potential threats of these viruses to public health and provides recommendations for prevention, control, and research.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2022)

Article Plant Sciences

A novel high-resolution monophenolase/diphenolase/radical scavenging profiling for the rapid screening of natural whitening candidates from Peaonia lactiflora root and their mechanism study with molecular docking

Chu Chu et al.

Summary: This study focused on identifying active components from the root of Paeonia lactiflora, discovering tyrosinase inhibitors and antioxidants, and exploring their mechanisms for skin whitening, offering a new approach for developing natural whitening agents.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Review Biochemistry & Molecular Biology

Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents

Asim Najmi et al.

Summary: Natural products are an important source of new lead compounds in drug discovery research, especially those derived from plants. Despite pharmaceutical companies' lack of attention to natural product drug discovery, recent technological advancements have revived scientific interest. This review provides a comprehensive overview of the various approaches used in selecting, authenticating, extracting/isolating, screening, and developing natural products, with a focus on bioactivity-guided fractionation. The integration of interdisciplinary approaches, technological advances, and new methods holds great potential for the future development of therapeutic drugs.

MOLECULES (2022)

Article Chemistry, Medicinal

Sialidase Inhibitors with Different Mechanisms

Joseph M. Keil et al.

Summary: Sialidases are enzymes that hydrolyze sialic acid-containing molecules and play important roles in biological pathways. Inhibitors of sialidases, such as transition-state analogues, mechanism-based inhibitors, suicide substrate inhibitors, product analogue inhibitors, and natural product inhibitors, have been developed and studied for their potential therapeutic applications.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Plant Sciences

Investigating the hemostatic effect of medicinal plant Arnebia euchroma (Royle) IMJohnst extract in a mouse model

Nuramatjan Ablat et al.

Summary: The ethyl acetate extract of Arnebia euchroma showed potential hemostatic effects in mice by shortening bleeding and clotting time, increasing platelet count, inducing platelet aggregation, adhesion, and PF-4 secretion, as well as increasing fibrinogen levels while shortening TT.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Review Plant Sciences

Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: A review

Anil Kumar et al.

Summary: This study explores the phytochemical composition, distribution, and ethno-medicinal uses of Arnebia euchroma (Royle) I.M. Johnst, commonly known as Ratanjot in the Indian subcontinent. The plant has traditional uses in Unani, Ayurvedic, and Chinese medicines for its anti-fungal and anti-microbial properties. Further research is needed to fully understand its medicinal importance and potential applications in treating various diseases.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Chemistry, Medicinal

AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings

Jerome Eberhardt et al.

Summary: AutoDock Vina is a widely used open-source program for molecular docking with new features such as support for macrocycles and explicit water molecules. The latest version also includes support for AutoDock4.2 scoring function, simultaneous docking of multiple ligands, and a batch mode for docking a large number of ligands. Python bindings have been implemented to facilitate scripting and workflow development.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)

Article Plant Sciences

Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-PDA-HRMS-SPE-NMR Analysis for the Identification of Potentially Antidiabetic Chromene Meroterpenoids from Rhododendron capitatum

Chao Liang et al.

Summary: Thirteen new chromene meroterpenoids were identified from ethyl acetate extract of Rhododendron capitatum, along with one known compound and other compounds. The structures of the new compounds were elucidated through NMR analysis and their absolute configurations were determined through ECD spectroscopy analysis. Some of the compounds exhibited inhibitory activity against α-glucosidase and PTP1B.

JOURNAL OF NATURAL PRODUCTS (2021)

Review Immunology

Sialidases From Clostridium perfringens and Their Inhibitors

Yan-hua Wang

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Article Chemistry, Organic

Archromones A-F, unusual polycyclic dearomatic geranylquinol derivatives from the roots of Arnebia euchroma

Hai-Wei Yan et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2020)

Review Immunology

Colistin and its role in the Era of antibiotic resistance: an extended review (2000-2019)

Mohamed Abd El-Gawad El-Sayed Ahmed et al.

EMERGING MICROBES & INFECTIONS (2020)

Review Plant Sciences

Combating influenza: natural products as neuraminidase inhibitors

Nisha Singh et al.

PHYTOCHEMISTRY REVIEWS (2019)

Review Infectious Diseases

Neuraminidase inhibitor resistance in influenza: a clinical perspective

Nelson Lee et al.

CURRENT OPINION IN INFECTIOUS DISEASES (2018)

Article Plant Sciences

The effects of Arnebia euchroma ointment on second-degree burn wounds: a randomized clinical trial

Ebrahim Nasiri et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

Review Biochemistry & Molecular Biology

The Traditional Medicine and Modern Medicine from Natural Products

Haidan Yuan et al.

MOLECULES (2016)

Article Dermatology

Effect of Arnebia euchroma ointment on post-laser wound healing in rats

Jale Aliasl et al.

JOURNAL OF COSMETIC AND LASER THERAPY (2015)

Editorial Material Biotechnology & Applied Microbiology

Sialidase inhibitors DAMPen sepsis

James C. Paulson et al.

NATURE BIOTECHNOLOGY (2011)

Article Biochemical Research Methods

A rapid HPLC/ESI-MS/MS method for quantitative analysis of isovalerylshikonin in rat plasma

MeiXiang Zhu et al.

BIOMEDICAL CHROMATOGRAPHY (2010)

Article Biotechnology & Applied Microbiology

Effect of pharynx epithelial cells surface desialylation on receptor-mediated adherence of Staphylococcus aureus

S. Sakarya et al.

JOURNAL OF APPLIED MICROBIOLOGY (2010)

Article Immunology

The NanA Neuraminidase of Streptococcus pneumoniae Is Involved in Biofilm Formation

Dane Parker et al.

INFECTION AND IMMUNITY (2009)

Article Chemistry, Multidisciplinary

Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design

Rommie E. Amaro et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Medicine, Research & Experimental

Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production

Grace Soong et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)