Journal
GENETICS
Volume 203, Issue 2, Pages 649-665Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.114.169748
Keywords
Tetrahymena thermophila; ciliates; model organism; genetics; amitosis; somatic polyploidy
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Funding
- National Institutes of Health-National Institute of General Medical Sciences [GM099820]
- Pew Biomedical Scholars Program
- Boettcher Foundation
- University of California Santa Barbara Academic Senate Research Award
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Tetrahymena thermophila is a ciliate model organism whose study has led to important discoveries and insights into both conserved and divergent biological processes. In this review, we describe the tools for the use of Tetrahymena as a model eukaryote, including an overview of its life cycle, orientation to its evolutionary roots, and methodological approaches to forward and reverse genetics. Recent genomic tools have expanded Tetrahymena's utility as a genetic model system. With the unique advantages that Tetrahymena provide, we argue that it will continue to be a model organism of choice.
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