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Summary: Chemodynamic therapy (CDT) relies on the transformation of intracellular hydrogen peroxide (H2O2) to hydroxyl radicals (OH) under the catalysis of Fenton/Fenton-like reagents, which amplifies oxidative stress and induces cellular apoptosis. However, CDT efficacy is limited by overexpressed GSH and insufficient endogenous H2O2 in tumors. Cu2+ and glucose oxidase (GOD) co-delivery can lead to GSH depletion and amplify the Fenton-like reaction. pH-responsive metal-organic frameworks (MOFs) are ideal for delivering Fenton/Fenton-like ions to tumors. However, it is challenging to abundantly dope Cu2+ in ZIF-8 MOF nanoparticles in aqueous conditions. This study developed a biomimetic mineralization method to synthesize GOD@Cu-ZIF-8, which showed promising antitumor capability through enhanced CDT in vitro and in vivo.
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Summary: In this study, a dual-targeted, multifunctional nanoplatform (FAA@CM) was successfully synthesized for trimodal imaging-guided photothermal/chemodynamic synergistic therapy. The nanoplatform achieved highly precise tumor-specific delivery through dual-targeting capability derived from 4T1 cell membrane cloaking and magnetic targeting. It exhibited trimodal imaging capabilities and enabled complete elimination of 4T1 tumors in mice.
ACS APPLIED MATERIALS & INTERFACES
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Summary: A novel nanozyme, A-NiB@C-IrOx, consisting of amorphous NiB alloy core completely coated with an ultrathin layer of IrOx shell, demonstrates efficient self-cascade catalysis for continuous generation of ROS and depletion of GSH, leading to high therapeutic efficiency.
ACTA BIOMATERIALIA
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Nguyen Thi Nguyen et al.
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Article
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Miao Wang et al.
Summary: Co-CeO2@PEG hollow nanospheres are synthesized for H2O2 replenishment in tumor microenvironment (TEM). The Co doping increases oxygen vacancy and promotes ROS generation. The hollow structure introduces extra cavitation nucleus for enhanced cavitation effect and ROS generation. Co-CeO2@PEG also exhibits mimic peroxidase and catalase behavior for chemodynamic therapy (CDT) and O-2 supplementation. Synergetic CDT/starvation/sonodynamic therapy (SDT) shows remarkable anticancer efficiency and immune response for metastasis inhibition.
CHEMICAL ENGINEERING JOURNAL
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Shirui Zhang et al.
Summary: In this study, a heterojunction-enhanced nanocatalytic-sonodynamic therapy platform based on Co3O4@TiO2-x Z-scheme heterojunctions was reported. The platform possesses ultrasound-triggered ROS generation ability and triple enzyme-mimic activities, resulting in amplified ROS levels and relief of tumor hypoxia. The construction of Z-scheme heterojunctions effectively enhances the enzyme-mimic activities and sonodynamic properties, leading to complete tumor eradication. This work opens up a promising approach for the development of semiconductor heterojunctions with both sonodynamic and enzyme-mimic activities for enhanced nanocatalytic-sonodynamic combination therapy.
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Summary: A light-controlled oxidative stress amplifier system is designed in this study, showing synergistic antitumor activity in solid tumors. The system self-produces H2O2 and transforms cold tumors, and the combination of photothermal therapy, chemotherapy, and nanozyme-based catalytic therapy further enhances tumor immunogenic death and antitumor immunity.
ADVANCED FUNCTIONAL MATERIALS
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Summary: In this study, a sonosensitizer AuNPs@Ir1 was developed by hybridizing an organometallic Ir(III) complex with ultrasmall gold nanoparticles for efficient tumor sonodynamic therapy. AuNPs@Ir1 rapidly entered cancer cells under ultrasound irradiation and induced cancer cell oncosis. The results demonstrated the excellent in-vitro and in-vivo anticancer profile of AuNPs@Ir1, which has the potential to expand the scope of sonodynamic therapy for metal-based anticancer drugs.
CHINESE CHEMICAL LETTERS
(2022)
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Xiaoyu Yuan et al.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
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Review
Engineering, Biomedical
Lu Zhang et al.
Summary: Chemodynamic therapy (CDT) is a novel cancer therapeutic strategy using a Fenton or Fenton-like reaction to generate highly cytotoxic hydroxyl radicals (·OH) from endogenous hydrogen peroxide (H2O2) to kill cancer cells, but its low catalytic efficiency and off-target side effects limit its biomedical application, so various strategies are needed to enhance its therapeutic effect.
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Summary: In this study, a nanozyme resembling cytochrome c oxidase was demonstrated for nanocatalytic cancer therapy. By loading a bioreductive predrug, it simultaneously achieved starvation, ferroptosis, and chemical therapy, resulting in significant tumor elimination and increased survival rate in tumor-bearing mice.
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Summary: The novel CuMo2S3-PEG-Gd nanocomposites have shown promising results in cancer treatment, with high photothermal conversion efficiency, excellent biocompatibility, and good biosecurity. They also demonstrate clear MRI performance for tumor guidance and a remarkable synergistic effect in both in vitro and in vivo PTT/PDT/CDT, efficiently inhibiting tumor growth. Overall, CuMo2S3-PEG-Gd nanocomposites have great potential as theranostic agents for tumors.
Article
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Xiao-Xin Yang et al.
Summary: This study presents an efficient chemodynamic therapy strategy based on dihydroartemisinin (DHA) as a substitute for H2O2 and recruiter of iron ions, leading to greatly increased reactive oxygen species generation for synergistic cancer therapy. Results demonstrate that DHA@MIL-101 nanoreactor significantly enhances intracellular iron ions and induces ferroptosis through ROS and LPO accumulation, ultimately causing DNA and mitochondria damage to induce apoptosis of malignant cells, with minimal systemic toxicity observed in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
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Wentao Dang et al.
Summary: In this study, 3D printed hydrogel scaffolds incorporating Gel-SA-CuO were developed for efficient inhibition of postoperative liver cancer recurrence. CuO nanoparticles released Cu2+ to produce ROS and served as photothermal agents to generate heat, enhancing the tumor inhibition through Fenton-like reaction and inducing ferroptosis via GSH depletion.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
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Zhongmin Tang et al.
Summary: In the field of nanomedicine, it is important to match designed nanomaterials with suitable orthotopic cancer models. Understanding the specific features of the chosen cancer model and introducing a proper therapy strategy using designed nanomaterials are crucial. Combining Fenton chemistry with zinc peroxide nanoparticles in the treatment of orthotopic liver cancer shows promising results of customized and enhanced chemodynamic therapy and protection of normal liver cells.
Article
Chemistry, Multidisciplinary
Tongtong Nie et al.
Summary: This study developed a ferroptosis-inducing agent that can trigger ferroptosis-like cancer cell death through sonodynamic therapy. The agent promotes the accumulation of lipid peroxide through ultrasound stimulation and enhances ferroptosis by depleting glutathione. Experimental results demonstrate that the agent has significant ability to reduce intracellular glutathione content and enhance sonodynamic therapy-triggered ferroptosis-like cancer cell death.
ADVANCED MATERIALS
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Haoying Ge et al.
Summary: The complex environment of cisplatin-resistant tumors requires a comprehensive and effective strategy to overcome resistance. In this study, a smart network combining sonodynamic therapy and a nanoenzyme was developed to reverse cisplatin resistance and enhance ovarian cancer treatment. The network effectively inhibited detoxification of cisplatin and prevented its efflux, while also disrupting ATP production and inhibiting DNA repair.
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Xiaoxiong Xiao et al.
Summary: In this study, a new DNA nanozyme was developed for enhanced photodynamic therapy (PDT) and synergistic tumor ferroptosis. The nanozyme exhibited catalase-mimic activity and was able to generate reactive oxygen species (ROS) upon light triggering. It also had high biological stability and compatibility, and could effectively target tumor cells for therapy. By catalyzing the decomposition of H2O2, the nanozyme relieved hypoxia and achieved glutathione depletion and cell ferroptosis for synergistic tumor therapy. The nanostructure showed excellent biocompatibility and could accumulate effectively in tumors for multi-modal tumor therapy.
JOURNAL OF NANOBIOTECHNOLOGY
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Sakthivel Perumal et al.
Summary: Dispersion of ultrafine iridium oxide nanoparticles over nanosheet-shaped zeolitic imidazolate framework (ZIF) surface of bimetallic Ni/Co-ZIF-67 leads to superior oxygen evolution electrocatalysis performance. The optimized electrode assembly with high IrOx loading amount and evenly dispersed IrOx nanoparticles exhibits excellent catalytic parameters.
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Summary: A novel all-in-one Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is designed for synergistic chemodynamic, photodynamic, and photothermal therapy in the tumor microenvironment, demonstrating outstanding therapeutic outcomes. The mechanisms of intraparticulate interactions, sustainability, and self-replenishment are carefully revealed, providing new insights into the design of novel nanozymes for efficient nanocatalytic therapy with high specificity and low side effects.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Yaofeng Zhou et al.
Summary: Various strategies have been developed to increase the efficiency of the intratumoral Fenton reaction in chemodynamic therapy (CDT), enhancing the therapeutic efficacy. The introduction of reinforcement strategies can improve treatment efficiency and promote the development of enhanced CDT-based multimodal anticancer therapies.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Zhongmin Tang et al.
Summary: This review provides a comprehensive overview of the importance and representative applications of Fenton chemistry in the field of biomedicine, as well as future directions for development, which is essential for further advancement in this field.
Review
Chemistry, Multidisciplinary
Chenyang Zhang et al.
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Chemistry, Multidisciplinary
Shu-Lan Li et al.
Summary: Chemodynamic therapy (CDT) uses endogenous chemical energy in the tumor microenvironment for treatment, converting hydrogen peroxide into reactive oxygen species for oncotherapy. However, limitations in the tumor microenvironment hinder CDT efficacy, and the development of nanotechnology offers potential solutions to improve CDT efficiency.
ADVANCED FUNCTIONAL MATERIALS
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Juan Ruan et al.
Summary: The Fenton-like reactions driven by manganese-based nanostructures can be tuned by a controllable release of Mn ions, leading to specific toxicity to cancer cells. The ZnxMn1-xS@PDA composites show potential for synergistic chemodynamic and photothermal therapies for cancer treatment.
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Wenyao Zhen et al.
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