Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF-κB activation

Article Oncology

Protective effect of restrictive resuscitation on vascular endothelial glycocalyx in pigs with traumatic hemorrhagic shock

Yunfei Chi et al.

Summary: Restrictive resuscitation can inhibit the shedding of vascular endothelial glycocalyx and achieve similar tissue oxygen supply effect as full resuscitation in prehospital treatment of traumatic hemorrhagic shock pigs.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Review Immunology

NF-?B: blending metabolism, immunity, and inflammation

Daria Capece et al.

Summary: This review discusses the central role of NF-KB transcription factors in the immune and metabolic systems, and how their understanding can lead to better diagnostics and therapeutics for human diseases.

TRENDS IN IMMUNOLOGY (2022)

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Article Respiratory System

PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-κB signaling pathway

Zhirong Huan et al.

Summary: This study demonstrated that PTPRO knockdown may contribute to attenuating inflammation in HS-induced lung injury via inhibiting NF-kappa B pathway activation.

RESPIRATORY RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

Hantae Jo et al.

Summary: MSCs play a key role in promoting repair of damaged and aging skin by increasing cell proliferation, neovascularization, collagen and elastic fiber production. iPSC-derived MSCs are considered advanced MSCs for cell therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination

Lingyun Zhang et al.

Summary: Inflammasomes are important for innate immunity against infections but can also contribute to inflammatory diseases when deregulated. Peli1, as an E3 ubiquitin ligase, plays a critical role in regulating the activation of NLRP3 inflammasome by promoting ASC ubiquitination and facilitating inflammasome assembly. Deficiency in Peli1 impairs NLRP3-induced caspase-1 activation and IL-1 beta maturation, highlighting its significance as an inflammasome regulator.

CELL REPORTS (2021)

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Article Cell & Tissue Engineering

RIPK1 Coordinates Bone Marrow Mesenchymal Stem Cell Survival by Maintaining Mitochondrial Homeostasis via p53

Qing Tian et al.

Summary: The research highlights the essential role of RIPK1 in the survival of bone marrow mesenchymal stem cells, as its knockdown affects cell proliferation, differentiation, and migration, leading to mitochondrial dysfunction and apoptosis. Moreover, the p53-PUMA axis pathway is involved in mitochondrial dysfunction in RIPK1-deficient bone marrow MSCs.

STEM CELLS INTERNATIONAL (2021)

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Review Neurosciences

Effects of Mdivi-1 on Neural Mitochondrial Dysfunction and Mitochondria-Mediated Apoptosis in Ischemia-Reperfusion Injury After Stroke: A Systematic Review of Preclinical Studies

Nguyen Thanh Nhu et al.

Summary: This systematic review evaluated the effects of Mdivi-1 on neural mitochondrial dysfunction and neural mitochondria-mediated apoptosis in I/R-induced brain injury after ischemic stroke. The findings suggest that Mdivi-1 can protect neural mitochondrial functions and reduce neural mitochondria-mediated apoptosis.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Article Cell & Tissue Engineering

PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm

Sharon Muggeo et al.

Summary: PBX1 plays a crucial role in regulating the balance between self-renewal and differentiation in hematopoietic stem cells, as well as maintaining proto-oncogenic transcriptional pathways. Studies have shown that lack of PBX1 can prevent the development of MPN caused by the JAK2V617F mutation, suggesting that modulation of the PBX1-driven transcriptional program could be a novel therapeutic approach.

STEM CELL REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction

Zheng Xiao et al.

Summary: This study demonstrates that Fer-1 can improve sepsis-induced cardiac dysfunction through multiple mechanisms, such as inhibiting ferroptosis, reducing cardiac damage and inflammatory responses.

BIOENGINEERED (2021)

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Review Immunology

Therapeutic Potential of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Prevention of Organ Injuries Induced by Traumatic Hemorrhagic Shock

Guillaume Valade et al.

Summary: Severe trauma leading to hemorrhagic shock is the main cause of death among young people worldwide. Traumatic hemorrhagic shock is a complex phenomenon involving secondary injuries and immune dysfunction. Mesenchymal stromal cells and their extracellular vesicles show potential therapeutic benefits in treating shock by modulating immune response.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

Centhaquine Restores Renal Blood Flow and Protects Tissue Damage After Hemorrhagic Shock and Renal Ischemia

Amaresh K. Ranjan et al.

Summary: The study shows that Centhaquine (CQ) can increase renal blood flow, enhance hypoxia response, reduce tissue damage and apoptosis, and may be used for prevention/treatment of acute kidney injury.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Immunology

NLRP3 inflammasome activation and cell death

Yi Huang et al.

Summary: The NLRP3 inflammasome is a cytosolic multiprotein complex that responds to microbial infection, endogenous danger signals, and environmental stimuli. Its activation can induce pyroptosis and release of inflammatory cytokines, contributing to innate immune defense. However, aberrant activation of the NLRP3 inflammasome is associated with inflammatory diseases, and there is a close relationship between cell death pathways and NLRP3 inflammasome activation.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Cell & Tissue Engineering

IL-1β primed mesenchymal stromal cells moderate hemorrhagic shock-induced organ injuries

Clotilde Aussel et al.

Summary: The study evaluated the effects of naïve MSC and interleukin (IL)-1 beta-primed MSC in HS-induced organ injury, finding that early administration of MSCp reduced kidney and liver damage and enhanced the immunomodulatory activity of MSCs. These findings suggest that IL-1 beta priming could be a potential therapeutic strategy to prevent organ injuries following HS.

STEM CELL RESEARCH & THERAPY (2021)

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Article Endocrinology & Metabolism

Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Sepsis-Induced Acute Kidney Injury by Promoting Mitophagy of Renal Tubular Epithelial Cells via the SIRT1/Parkin Axis

Jun Guo et al.

Summary: The study showed that BMSCs could alleviate sepsis-induced acute kidney injury by inhibiting inflammation, promoting mitophagy, and upregulating SIRT1/Parkin. These findings provide evidence for the role of BMSCs in treating SI-AKI.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Review Cell Biology

The Therapeutic Potential of Mesenchymal Stromal Cells for Regenerative Medicine: Current Knowledge and Future Understandings

Makram Merimi et al.

Summary: Research on the therapeutic potential of progenitor cells, particularly mesenchymal stromal cells (MSCs), has significantly advanced in recent decades. MSCs have shown promise in regenerative medicine due to their ability to support tissue repair and regeneration through various therapeutic functions. The fate and behavior of MSCs are regulated by their microenvironment, and their therapeutic effects may be achieved through a paracrine pathway involving the release of various messengers.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell & Tissue Engineering

Mesenchymal stem cells inhibited the differentiation of MDSCs via COX2/PGE2 in experimental sialadenitis

Jingjing Qi et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cell & Tissue Engineering

Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis

E. Xiang et al.

STEM CELL RESEARCH & THERAPY (2020)

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Review Immunology

Immunomodulatory Effects of Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Extracellular Vesicles in Rheumatoid Arthritis

Huan Liu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB ActivationviaGPR81-Mediated Signaling

Kun Yang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Cell Biology

Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Sahar Esfandyari et al.

CELLS (2020)

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Review Cell & Tissue Engineering

Mesenchymal stem cells: amazing remedies for bone and cartilage defects

Parisa Kangari et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Biochemistry & Molecular Biology

An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells

Valentina Perotti et al.

ONCOGENE (2019)

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Article Gastroenterology & Hepatology

Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury

Yang Xie et al.

HEPATOLOGY (2019)

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Review Immunology

Caspases in Cell Death, Inflammation, and Disease

Nina Van Opdenbosch et al.

IMMUNITY (2019)

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Article Cell & Tissue Engineering

PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

Yixu Jiang et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Cell Biology

NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling

Feilin Liu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Review Immunology

NLRP3 Inflammasome and Inflammatory Bowel Disease

Yu Zhen et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages

Weiming Zhao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Article Medicine, Research & Experimental

The rescue effect of mesenchymal stem cell on sodium iodate-induced retinal pigment epithelial cell death through deactivation of NF-kappa B-mediated NLRP3 inflammasome

Xiying Mao et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Nanoscience & Nanotechnology

Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol-co-polycaprolactone-co-polyethylenimine nanoparticles for diabetic nephropathy therapy

Danfei Chen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Critical Care Medicine

Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma

Rebecca Halbgebauer et al.

JOURNAL OF CRITICAL CARE (2018)

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Article Medicine, General & Internal

Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-kappa B and improving mitochondrial function

Xiaowen Yu et al.

EBIOMEDICINE (2018)

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Article Multidisciplinary Sciences

REV-ERB alpha integrates colon clock with experimental colitis through regulation of NF-kappa B/NLRP3 axis

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NATURE COMMUNICATIONS (2018)

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Review Physiology

Biomarkers in acute kidney injury - pathophysiological basis and clinical performance

E. V. Schrezenmeier et al.

ACTA PHYSIOLOGICA (2017)

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Article Urology & Nephrology

Targeted Exome Sequencing Identifies PBX1 as Involved in Monogenic Congenital Anomalies of the Kidney and Urinary Tract

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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Hypoxia Inducible Factor-1α Regulates the Migration of Bone Marrow Mesenchymal Stem Cells via Integrin α4

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STEM CELLS INTERNATIONAL (2016)

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Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan

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Stromal Cell-Derived Factor-1β Mediates Cell Survival through Enhancing Autophagy in Bone Marrow-Derived Mesenchymal Stem Cells

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PLOS ONE (2013)

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Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence

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CELL STEM CELL (2008)

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NATURE REVIEWS IMMUNOLOGY (2008)

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Clinical review: Hemorrhagic shock

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Pbxl regulates nephrogenesis and ureteric branching in the developing kidney

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DEVELOPMENTAL BIOLOGY (2003)

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Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF-κB activation

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