Journal
JACC-CLINICAL ELECTROPHYSIOLOGY
Volume 9, Issue 8, Pages 1235-1245Publisher
ELSEVIER
DOI: 10.1016/j.jacep.2023.02.014
Keywords
conduction velocity; ischemic; cardiomyopathy; lipomatous metaplasia; myocardial infarction; ventricular; tachycardia
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Myocardial lipomatous metaplasia (LM) is associated with post-infarct ventricular tachycardia (VT) circuitry, possibly mediated by slowing nearby corridor conduction velocity (CV) to facilitate circuit re-entry.
BACKGROUND Myocardial lipomatous metaplasia (LM) has been reported to be associated with post-infarct ventricular tachycardia (VT) circuitry. OBJECTIVES This study examined the association of scar versus LM composition with impulse conduction velocity (CV) in putative VT corridors that traverse the infarct zone in post-infarct patients. METHODS The cohort included 31 post-infarct patients from the prospective INFINITY (Intra-Myocardial Fat Deposition and Ventricular Tachycardia in Cardiomyopathy) study. Myocardial scar, border zone, and potential viable corridors were defined by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR), and LM was defined by computed tomography. Images were registered to electroanatomic maps, and the CV at each electroanatomic map point was calculated as the mean CV between that point and 5 adjacent points along the activation wave front. RESULTS Regions with LM exhibited lower CV than scar (median = 11.9 vs 13.5 cm/s; P < 0.001). Of 94 corridors computed from LGE-CMR and electrophysiologically confirmed to participate in VT circuitry, 93 traversed through or near LM. These critical corridors displayed slower CV (median 8.8 [IQR: 5.9-15.7] cm/s vs 39.2 [IQR: 28.1-58.5]) cm/s; P < 0.001) than 115 noncritical corridors distant from LM. Additionally, critical corridors demonstrated low-peripheral, high-center (mountain shaped, 23.3%) or mean low-level (46.7%) CV patterns compared with 115 noncritical corridors distant from LM that displayed high-peripheral, low-center (valley shaped, 19.1%) or mean high-level (60.9%) CV patterns. CONCLUSIONS The association of myocardial LM with VT circuitry is at least partially mediated by slowing nearby corridor CV thus facilitating an excitable gap that enables circuit re-entry. (c) 2023 by the American College of Cardiology Foundation.
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