Identification of novel inhibitors from Urtica spp against TNBC targeting JAK2 receptor for breast cancer therapy

Article Integrative & Complementary Medicine

Identification of SARS-CoV-2 Spike Protein Inhibitors from Urtica dioicato Develop Herbal-Based Therapeutics Against COVID-19

Shobha Upreti et al.

Summary: The high transmission rate and mutations of SARS-CoV-2 have led to a global pandemic, and the lack of effective clinical treatments has caused major concerns. Synthetic antiviral drugs have severe side effects, making the promotion of herbal-based drug development crucial. Molecular docking studies have identified compounds from U. dioica with significant antiviral and anti-SARS activity against SARS-CoV-2 spike protein.

WORLD JOURNAL OF TRADITIONAL CHINESE MEDICINE (2023)

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Review Immunology

Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review

Teklie Mengie Ayele et al.

Summary: The JAK2/STAT3 signaling pathway plays a crucial role in regulating various biological processes such as cell proliferation, differentiation, apoptosis, and immune system control. Aberrantly activated JAK2/STAT3 is associated with the development and metastasis of various tumors, while the JAK3/STAT3 pathway shows promise as a potential therapeutic target in solid tumor treatment.

JOURNAL OF INFLAMMATION RESEARCH (2022)

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Article Chemistry, Multidisciplinary