Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 132, Issue -, Pages 27-33Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2015.04.067
Keywords
Graphene; CGS; Hemostatic sponge; Hemostasis; Clotting
Funding
- National Natural Science Foundation of China [21204004]
- Beijing Natural Science Foundation [2132040]
- Specialized Research Fund for the Doctoral Program of Higher Education [20120010120011]
- Open Project of State Key Laboratory of Chemical Resource Engineering and the Fundamental Research Funds for Central Universities [YS1407]
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In this study, we demonstrate for the first time the remarkable hemostatic performance of a cross-linked graphene sponge (CGS) as a superb hemostat. The CGS can absorb plasma immediately (<40 ms) to form a blood cell layer and promotes subsequent clotting. The interaction between the interface of the CGS and blood cells reveals that the fast blood coagulation is primarily attributed to the enrichment of hemocytes and platelets on the wound surface. An in vitro dynamic whole-blood clotting test further highlights the effectiveness of the CGS. Considering the facile preparation, low cost, nontoxicity, and long shelf life of the portable black sponge, the CGS has great potential for trauma treatment. (c) 2015 Elsevier B.V. All rights reserved.
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