Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1295, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2023.136688
Keywords
Cytotoxicity; MDA-MB-231; Photodynamic therapy; Phthalocyanine; Singlet oxygen; zinc
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This study reports a new photosensitizer for the treatment of triple negative breast cancer, and investigates its photophysical and photochemical properties. The compound shows strong photodynamic activity against MDA-MB-231 cells in vitro.
Breast cancer is a common type of cancer among women worldwide. Triple negative breast cancer is a highly aggressive subtype of breast cancer and accounts for approximately 24% of all identified breast cancer cases. In triple negative breast cancer, the therapeutic approach options are very limited. In this study, 4-[2 ',3 ',5 ',6 '-tet-rafluoro-4 '-(1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranosyl)benzyloxy]phthalonitrile and its peripherally tetra substituted zinc phthalocyanine derivatives are reported for the first time. Photophysical and photochemical properties of the glycosylated zinc(II) phthalocyanine derivative were investigated for its suitability for use as a photosensitizer in photodynamic therapy. The fluorescence (phi F: 0.089), singlet oxygen (phi d: 0.45) and photo-degradation quantum yields (phi Delta: 6.07x10- 5) of this compound were carried out in N,N-dimethylformamide. The in vitro photodynamic activities of this compound against MDA-MB-231 cells were also studied. Cytotoxicity analysis in this cell lines was performed by MTT (3-(4,5-dimethylthiazol-2-yl) method. Cytotoxicity test was applied on cell lines of MDA-MB-231 and HUVEC. The IC50 value is determined for glycosylated zinc(II) Pc derivative.
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