Individual Features of the Hypothalamic-Pituitary-Thyroid Axis Functioning during Aging in Non-Human Primates

Individual features of age-related changes in the function of the neuroendocrine systems are an important problem as the basic component of a personalized approach to predicting and treating age-related pathologies. We studied the age-related features of the function of the hypothalamic-pituitary-thyroid axis in laboratory primates with depression- and anxiety-like behavior (DAB). It was found that in young female rhesus monkeys with DAB, the basal and thyrotropin-releasing hormone-stimulated levels of thyroid-stimulating hormone were significantly lower than in young animals with standard behavior (control). During aging, the levels of thyroid-stimulating hormone increased in DAB animals and free thyroxine concentrations decreased both at baseline (fasting) and in response to the thyrotropin-releasing hormone test, while in animals with standard behavior, only a trend towards similar hormonal changes was revealed.

Automated summary

The individual features of age-related changes in the function of neuroendocrine systems are crucial for personalized approaches to predicting and treating age-related pathologies. The study found that young female rhesus monkeys with depression- and anxiety-like behavior had lower levels of thyroid-stimulating hormone compared to young animals with standard behavior. Additionally, with aging, the levels of thyroid-stimulating hormone increased in animals with depression- and anxiety-like behavior, while there was only a trend towards similar hormonal changes in animals with standard behavior.