Journal
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
Volume 74, Issue 3, Pages 207-217Publisher
SCIENDO
DOI: 10.2478/aiht-2023-74-3768
Keywords
biocompatibility; blood biochemistry; genotoxicity; histology; in vivo toxicity; micronucleus test; polymers
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This study demonstrates that L-glutamic acid-g-p(HEMA) polymeric nanoparticles are biocompatible and have the potential to be used as a drug delivery system, as they show no toxicity in mice and can effectively distribute to organs and bone marrow.
The aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by ex vivo imaging with the IVIS (R) spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.
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