☆ 4.8 Review

Advances and perspectives in fluorescent probes for imaging hepatopathy-related biomarkers

COORDINATION CHEMISTRY REVIEWS (2023)

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Viscosity activated NIR fluorescent probe for visualizing mitochondrial viscosity dynamic and fatty liver mice

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Dual-Channel Fluorescent Probe for Detecting Viscosity and ONOO- without Signal Crosstalk in Nonalcoholic Fatty Liver

Yijia Liu et al.

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Optimizing phenyl selenide-based BODIPYs as fluorescent probes for diagnosing cancer and drug-induced liver injury via cysteine

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Viscosity-sensitive NIR probe for in vivo imaging of early-stage hepatic fibrosis

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Summary: Alterations in hepatic lipid metabolism may contribute to the onset of non-alcoholic fatty liver disease. Zhou et al. identify orosomucoid 2 (ORM2) as a key regulator of lipid homeostasis in the liver. ORM2 activates the AMP-activated protein kinase signaling to inhibit lipogenesis. Additionally, injections of ORM2 protein improved liver steatosis and atherosclerosis.

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An ultrasensitive lipid droplet-targeted NIR emission fluorescent probe for polarity detection and its application in liver disease diagnosis

Yonghe Tang et al.

Summary: Research has shown that the number and distribution of lipid droplets in cells change significantly during the production of lesions, with unclear predisposing factors leading to limitations in the early diagnosis and treatment of liver diseases. By using the near-infrared emission fluorescent probe SSR-LDs, researchers successfully monitored changes in lipid droplet polarity in cells, providing a new tool for medical diagnosis of diseases related to lipid droplet polarity.

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A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury

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Summary: We proposed to monitor the early stage of alcohol-induced liver injury by quantitatively detecting Golgi viscosity. A Golgi-targeted fluorescent rotor (GA-Vis) was developed for this purpose. Changes in Golgi viscosity during alcohol-induced liver injury were quantitatively evaluated using GA-Vis through fluorescence lifetime imaging in live cells and zebrafish. GA-Vis was qualified as a practical tool for future diagnoses of alcohol-induced liver injury.

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Jinlong Zhang et al.

Summary: In this study, a novel fluorescent probe was developed for the detection of H2S. The probe showed comparable imaging performance to the traditional probe but exhibited lower toxicity to cells and animals.

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A smart probe for simultaneous imaging of the lipid/water microenvironment in atherosclerosis and fatty liver

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A novel near-infrared viscosity probe based on synergistic effect of AIE property and molecular rotors for mitophagy imaging during liver injury

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Summary: A new strategy combining AIE property and molecular rotors was proposed to design a novel viscosity probe, TPA-Py. The probe exhibited excellent near-infrared emission, good water-solubility, and mitochondrial targeting ability. TPA-Py showed potential for monitoring mitophagy and investigating viscosity changes in liver injury pathways.

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Article Chemistry, Analytical

Highly Selective Fluorescent Probe Design for Visualizing Hepatic Hydrogen Sulfide in the Pathological Progression of Nonalcoholic Fatty Liver

Wei Li et al.

Summary: A highly selective near-infrared fluorescent probe was developed using molecular probe design and nanofunctionalization techniques, allowing for real-time monitoring of hepatic H2S levels during NAFLD progression.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

In Vivo Imaging of the Macrophage Migration Inhibitory Factor in Liver Cancer with an Activity-Based Probe

Chenwen Shao et al.

Summary: A novel activity-based probe, TPP2, was reported for direct labeling and imaging of endogenous MIF activity within live cells and in a mouse model of liver cancer. TPP2 allows for the dynamic monitoring of intracellular MIF activity and the identification of liver cancer with high sensitivity and selectivity, providing a promising new imaging approach for elucidating MIF-related biological functions in liver cancer.

ANALYTICAL CHEMISTRY (2021)

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Review Medicine, Research & Experimental

Gut Microbiota in Intestinal and Liver Disease

Rheinallt M. Jones et al.

Summary: The gut microbiota plays a crucial role in the normal physiology of the gastrointestinal tract and liver, with disruptions in its community structure potentially leading to inflammation and immune activation. Long-term evolution has established a stable equilibrium between host and microbial influences, but alterations in this balance can result in a wide range of diseases.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

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Review Biochemistry & Molecular Biology

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

Johanna C. Arroyave-Ospina et al.

Summary: Oxidative stress plays a major role in the pathophysiology of chronic liver diseases, particularly in non-alcoholic liver disease (NAFLD). The antioxidant response, regulated by the Nrf2/ARE pathway, is crucial in combating oxidative stress-induced damage.

ANTIOXIDANTS (2021)

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Article Chemistry, Multidisciplinary

Effects of the molluscicide candidate PPU06 on alkaline phosphatase in the golden apple snails determined using a near-infrared fluorescent probe

Changxiaoxi Liu et al.

Summary: The study demonstrates a rapid ALP fluorescent identification method using the Niap probe, revealing that exposure to PPU06 led to increased ALP concentration in the liver of Pomacea canaliculata. The optical evidence may aid in the discovery of new chemistry for snail control.

CHINESE CHEMICAL LETTERS (2021)

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Article Chemistry, Analytical

Novel near-infrared fluorescence probe with large Stokes shift for monitoring CCl4-induced toxic hepatitis

Yang Tian et al.

Summary: A novel fluorescent probe DDM-ONOO- was developed in this study, which showed high sensitivity and excellent selectivity for detecting peroxynitrite (ONOO-) in toxic hepatitis. The probe was utilized for diagnosing and monitoring toxic hepatitis at cellular and mouse model levels through fluorescence imaging, 3D quantification analysis, and flow cytometry, proving to be a powerful tool for diagnosis and treatment of toxic hepatitis.

TALANTA (2021)

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Article Multidisciplinary Sciences

A2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging

Junjie Chen et al.

Summary: The research team developed an activatable nanoprobe by linking a benzothiadiazole core with specific groups, which can be cleaved and activated at disease sites, generating fluorescent emission and ultrasound signal for multi-mode imaging for detection and imaging.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Analytical

Dual-Colored Fluorescence Imaging of Mitochondrial HNO and Golgi-HNO in Mice with DILI

Hui Wang et al.

Summary: Drug-induced liver injury (DILI) is the most common reason for the post-marketing withdrawal of drugs. Research has identified a positive correlation between nitroxyl (HNO) levels in the Golgi apparatus and mitochondria and DILI, and uncovered the involvement of catalase in HNO synthesis.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Rapid Two-Photon Fluorescence Imaging of Monoamine Oxidase B for Diagnosis of Early-Stage Liver Fibrosis in Mice

Nannan Fan et al.

Summary: This study established a two-photon fluorescence imaging method for in vivo detection of MAO-B activity using a simply prepared probe, BiPhAA. The platform is more rapid than other current detection methods, allowing dynamic observation of endogenous MAO-B level changes in hepatic stellate cells. The BiPhAA-based imaging platform successfully distinguished mice with liver fibrosis from normal mice by showing six times higher fluorescence brightness in the liver tissue of fibrosis mice.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Rational Design of a Highly Selective Near-Infrared Two-Photon Fluorogenic Probe for Imaging Orthotopic Hepatocellular Carcinoma Chemotherapy

Xiaofeng Wu et al.

Summary: This study successfully developed a near-infrared two-photon fluorescent probe with high selectivity for imaging the HCC-related biomarker CE in vivo and in situ. The probe correlated well with tumor apoptosis, enabling accurate evaluation of HCC treatment status. This advancement may contribute to precision imaging-guided diagnosis and treatment evaluation of HCC in situ.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Visualization of endoplasmic reticulum viscosity in the liver of mice with nonalcoholic fatty liver disease by a near-infrared fluorescence probe

Yongqing Zhou et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) can cause serious liver damage, and early diagnosis and treatment of NAFLD can greatly improve treatment success rates. A new near-infrared (NIR) fluorescence imaging probe, Er-V, successfully monitored increased viscosity in the livers of mice with NAFLD, offering a new approach for early detection and diagnosis of NAFLD.

CHINESE CHEMICAL LETTERS (2021)

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Article Chemistry, Analytical

In vivo imaging via a red-emitting fluorescent probe to diagnosing liver cancer or drug-induced liver disease

Yuexia Yang et al.

Summary: A new highly selective fluorescent probe (DCDHF-Ala) for LAP detection has been synthesized, showing excellent performance and biosafety. It has been successfully applied in fluorescent imaging in cells and animal models, and may be useful for qualitatively monitoring liver injury and liver cancer.

ANALYTICA CHIMICA ACTA (2021)

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Article Biochemical Research Methods

Dynamic evaluation of the protective effect of Dendrobium officinale polysaccharide on acute alcoholic liver injury mice in vitro and in vivo by NIR fluorescence imaging

Gang Nie et al.

Summary: Acute alcoholic liver injury (AALI) poses a threat to human health, and Dendrobium officinale polysaccharide (DOP) may protect the liver by maintaining the balance of the anti-oxidative system, although further research is needed. Near-infrared (NIR) fluorescence imaging technique was used to dynamically evaluate the effect of DOP on AALI mice, showing that it can maintain the relative balance of glutathione content in the liver.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

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Review Chemistry, Inorganic & Nuclear

1,8-Naphthalimide based fluorescent sensors for enzymes

Conor Geraghty et al.

Summary: Fluorescent probes are essential tools in studying biological systems, and the 1,8-naphthalimide fluorophore is commonly used for detecting enzymatic conversions. With advancements in synthetic methods, the sensitivity and selectivity of these probes continue to improve.

COORDINATION CHEMISTRY REVIEWS (2021)

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Article Spectroscopy

Development of a one-step synthesized red emission fluorescent probe for sensitive detection of viscosity in vitro and in vivo

Jie Cheng et al.

Summary: Fluorescence imaging is an effective method for detecting biological parameters, and the NBI-V probe has good stability and high selectivity, making it suitable for detecting changes in viscosity both in vivo and in vitro.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Review Endocrinology & Metabolism

Metabolic hallmarks of liver regeneration

Roya Solhi et al.

Summary: This article emphasizes the dynamic changes of lipids, carbohydrates, and proteins during liver regeneration, as well as their coordination in the process. It also discusses the application of metabolic intervention in treating chronic liver diseases.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

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Article Chemistry, Multidisciplinary

Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury

Yong Zhang et al.

Summary: Hepatotoxicity is a serious issue in clinical drugs, and liver injury caused by chronic administration or overdose has become a major biosafety concern. Currently used near-infrared fluorescent probes for liver injury detection face issues with poor liver targeting ability and low sensitivity. An enzyme-activated fluorogenic probe with strong in situ targeting ability is crucial for improving liver injury imaging.

CHEMICAL SCIENCE (2021)

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Review Nutrition & Dietetics

Antioxidative and anti-inflammatory actions of reactive cysteine persulfides

Tianli Zhang et al.

Summary: Cysteine persulfide and polysulfides, sulfur-containing derivatives of cysteine, play diverse roles in biological processes including biosynthesis, signal transduction regulation, and cellular redox balance maintenance, suggesting their potential therapeutic implications in immune responses and oxidative stress protection.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2021)

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Article Chemistry, Multidisciplinary

Activatable photoacoustic/fluorescent dual-modal probe for monitoring of drug-induced liver hypoxia in vivot

Xiaopeng Fan et al.

Summary: A novel dual-modal probe (NO2-CS) was rationally developed and applied for imaging isoniazid-induced liver hypoxia by detecting the over-expressed nitroreductase, which is crucial for the effective monitoring and treatment of drug-induced liver injury.

CHEMICAL COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

A turn-on probe for detecting antituberculotic drug-induced liver injury in mice via NIR-II fluorescence/optoacoustic imaging

Longqi Chen et al.

Summary: A turn-on optoacoustic and NIR-II fluorescent probe, TC-H2O2, has been developed for imaging antituberculotic drug-induced liver injury. The probe responds to hepatic H2O2, releasing chromophore TC-NN, which displays prominent NIR-II fluorescence and optoacoustic signals for diagnosing liver injury.

CHEMICAL COMMUNICATIONS (2021)

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Article Materials Science, Biomaterials

Turn-on fluorescent probe for lipid droplet specific imaging of fatty liver and atherosclerosis

Shufen Li et al.

Summary: A novel NIR fluorescent probe TNBD was synthesized with low emission in aqueous solution and solid state, but enhanced emission in oleic acid. It exhibited impressive LD specific fluorescence turn-on ability in cells and disease samples, providing a new way to prepare a NIR LD targeted fluorescence probe.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Nanoscience & Nanotechnology

Utilizing a Solvatochromic Optical Agent to Monitor the Polarity Changes in Dynamic Liver Injury Progression

Junling Yin et al.

Summary: The polarity of the endoplasmic reticulum increases with the progression of liver injuries, and the ERNT probe shows promising clinical applications in evaluating hepatoprotective drug efficacy.

ACS APPLIED BIO MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A dual-rotator fluorescent probe for analyzing the viscosity of mitochondria and blood

Manlin Fu et al.

Summary: A novel mitochondria-targeting molecular rotator FD was designed to visualize changes in viscosity under hypoxic conditions in vitro and in vivo. Importantly, FD can be used to detect changes in the blood viscosity of liver cancer and liver cirrhosis patients, and also rehabilitation of liver disease.

CHEMICAL COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Diagnosis of fatty liver disease by a multiphoton-active and lipid-droplet-specific AIEgen with nonaromatic rotors

Hojeong Park et al.

Summary: Fatty liver disease (FLD) is a rising global health risk, with early diagnosis being challenging due to lack of suitable imaging tools. The fluorescent two-photon aggregation-induced emission (AIE) luminogen ABCXF shows potential as a high-contrast imaging agent for FLD tissue, outperforming Oil Red O.

MATERIALS CHEMISTRY FRONTIERS (2021)

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Review Pathology

Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns

Sungjin Ko et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020 (2020)

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Article Gastroenterology & Hepatology

Predictive factors for liver volume and function recovery after resection using three-dimensional analysis

Yutaka Nakano et al.

HPB (2020)

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Article Chemistry, Analytical

Visualization of Dynamic Changes in Labile Iron(II) Pools in Endoplasmic Reticulum Stress-Mediated Drug-Induced Liver Injury

Lijie Wu et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Enhancement of the Aggregation-Induced Emission by Hydrogen Bond for Visualizing Hypochlorous Acid in an Inflammation Model and a Hepatocellular Carcinoma Model

Xiaomin Han et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Novel Strategy for Validating the Existence and Mechanism of the Gut-Liver Axis in Vivo by a Hypoxia-Sensitive NIR Fluorescent Probe

Yang Tian et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Design of Activatable NIR-II Molecular Probe for In Vivo Elucidation of Disease-Related Viscosity Variations

Kun Dou et al.

ANALYTICAL CHEMISTRY (2020)

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Article Gastroenterology & Hepatology

Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice

Dafna Groeneveld et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Chemistry, Analytical

A simple but efficient fluorescent sensor for ratiometric sensing of Cd2+ and bio-imaging studies

Jian Hua Wang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Multidisciplinary

An Activatable AIEgen Probe for High-Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision

Haidong Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Engineering, Biomedical

The Plot Thickens: The Emerging Role of Matrix Viscosity in Cell Mechanotransduction

Marco Cantini et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Review Cell Biology

Hepatic lipid droplet homeostasis and fatty liver disease

Fabian Seebacher et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying

Haidong Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

Mitochondrial-Targeted and Near-Infrared Fluorescence Probe for Bioimaging and Evaluating Monoamine Oxidase A Activity in Hepatic Fibrosis

Zheng-Min Yang et al.

ACS SENSORS (2020)

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Article Chemistry, Analytical

Faster and More Specific: Excited-State Intramolecular Proton Transfer-Based Dyes for High-Fidelity Dynamic Imaging of Lipid Droplets within Cells and Tissues

Gangwei Jiang et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Mitochondria-Targeted Fluorescent and Photoacoustic Imaging of Hydrogen Peroxide in Inflammation

Xiaoxia Chen et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

A novel hepatocyte-targeting ratiometric fluorescent probe for imaging hydrogen peroxide in zebrafish

Wen-Li Jiang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Multidisciplinary

In situ visualization of peroxisomal viscosity in the liver of mice with non-alcoholic fatty liver disease by near-infrared fluorescence and photoacoustic imaging

Yongqing Zhou et al.

CHEMICAL SCIENCE (2020)

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Article Materials Science, Biomaterials

A visible and near-infrared dual-fluorescent probe for discrimination between Cys/Hcy and GSH and its application in bioimaging

Ruixi Li et al.

BIOMATERIALS SCIENCE (2020)

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Article Chemistry, Multidisciplinary

A biotin-guided hydrogen sulfide fluorescent probe and its application in living cell imaging

Chen Zhang et al.

RSC ADVANCES (2020)

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Article Chemistry, Multidisciplinary

An activatable probe for detecting alcoholic liver injury via multispectral optoacoustic tomography and fluorescence imaging

Junjie Chen et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Engineering a highly selective probe for ratiometric imaging of H2Snand revealing its signaling pathway in fatty liver disease

Wei Li et al.

CHEMICAL SCIENCE (2020)

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Article Gastroenterology & Hepatology

Burden of liver diseases in the world

Sumeet K. Asrani et al.

JOURNAL OF HEPATOLOGY (2019)

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Review Biochemistry & Molecular Biology

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Maurizio Parola et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

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Review Oncology

The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond

Silvia Pastorekova et al.

CANCER AND METASTASIS REVIEWS (2019)

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Review Biochemistry & Molecular Biology

Iron homeostasis and oxidative stress: An intimate relationship

Dimitrios Galaris et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

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Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease - A global public health perspective

Zobair M. Younossi

JOURNAL OF HEPATOLOGY (2019)

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Article Biochemistry & Molecular Biology

Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

Jianbin Bi et al.

REDOX BIOLOGY (2019)

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Article Medicine, Research & Experimental

Integration of metabolomics and expression of enolase-phosphatase 1 links to hepatocellular carcinoma progression

Hao Zhuang et al.

THERANOSTICS (2019)

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Article Engineering, Biomedical

Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration

Jordi Gonzalez-Molina et al.

BIOMATERIALS (2018)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

David Hojland Ipsen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Editorial Material Gastroenterology & Hepatology

A protective role for TREM2 in liver injury

Katrina Ray

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Review Pharmacology & Pharmacy

Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity

Anna Moles et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Cell Biology

Metabolic Remodeling during Liver Regeneration

Matias J. Caldez et al.

DEVELOPMENTAL CELL (2018)

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Article Gastroenterology & Hepatology

Abnormal Liver Enzymes

Jose Melendez-Rosado et al.

GASTROENTEROLOGY NURSING (2018)

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Review Public, Environmental & Occupational Health

Inflammation and cancer

Mariko Murata

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE (2018)

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Review Biochemical Research Methods

Protein purification and analysis: next generation Western blotting techniques

Manish Mishra et al.

EXPERT REVIEW OF PROTEOMICS (2017)

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Review Gastroenterology & Hepatology

The Origin of Fibrogenic Myofibroblasts in Fibrotic Liver

Tatiana Kisseleva

HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Syndecan-1 Limits the Progression of Liver Injury and Promotes Liver Repair in Acetaminophen-Induced Liver Injury in Mice

Eon Jeong Nam et al.

HEPATOLOGY (2017)

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Article Cell Biology

Altering the threshold of an excitable signal transduction network changes cell migratory modes

Yuchuan Miao et al.

NATURE CELL BIOLOGY (2017)

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Article Multidisciplinary Sciences

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Takaaki Akaike et al.

NATURE COMMUNICATIONS (2017)

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Article Radiology, Nuclear Medicine & Medical Imaging

Dual-energy computed tomography for the detection of focal liver lesions

K. N. Lago et al.

RADIOLOGIA (2017)

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Editorial Material Gastroenterology & Hepatology

Neurologic cues modulate immune-mediated liver injury and regeneration

Benjamin L. Woolbright et al.

HEPATOLOGY (2016)

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Article Biochemistry & Molecular Biology

Influence of cysteine 164 on active site structure in rat cysteine dioxygenase

Matthias Fellner et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2016)

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Review Cell Biology

Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer

Zhiqi Wang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

Hepatic Steatosis: Etiology, Patterns, and Quantification

Ilkay S. Idilman et al.

SEMINARS IN ULTRASOUND CT AND MRI (2016)

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Review Biochemistry & Molecular Biology

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

Alexander R. Bogdan et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Review Biochemistry & Molecular Biology

Reactive Oxygen Species in Inflammation and Tissue Injury

Manish Mittal et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Review Biochemistry & Molecular Biology

Novel Aspects of the Liver Microenvironment in Hepatocellular Carcinoma Pathogenesis and Development

Thomas Tu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

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Article Biotechnology & Applied Microbiology

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

Adam J. Shuhendler et al.

NATURE BIOTECHNOLOGY (2014)

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Article Biotechnology & Applied Microbiology

Enzyme clustering accelerates processing of intermediates through metabolic channeling

Michele Castellana et al.

NATURE BIOTECHNOLOGY (2014)

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Review Oncology

The Multifaceted Role of the Microenvironment in Liver Metastasis: Biology and Clinical Implications

Gert G. Van den Eynden et al.

CANCER RESEARCH (2013)

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Editorial Material Dermatology

Immunofluorescence Techniques

Ian D. Odell et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

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Article Clinical Neurology

Overview of Functional Magnetic Resonance Imaging

Gary H. Glover

NEUROSURGERY CLINICS OF NORTH AMERICA (2011)

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Article Surgery

Nitric Oxide and Redox Regulation in the Liver: Part I. General Considerations and Redox Biology in Hepatitis

Diana L. Diesen et al.

JOURNAL OF SURGICAL RESEARCH (2010)

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Article Multidisciplinary Sciences

Quantitative reactivity profiling predicts functional cysteines in proteomes

Eranthie Weerapana et al.

NATURE (2010)

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Review Physiology

Glycotoxines, Carbonyl Stress and Relevance to Diabetes and Its Complications

Z. Turk

PHYSIOLOGICAL RESEARCH (2010)

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Review Gastroenterology & Hepatology

Implication of normal liver enzymes in liver disease

Vincenza Calvaruso et al.

JOURNAL OF VIRAL HEPATITIS (2009)

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Review Biotechnology & Applied Microbiology

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

Csaba Szabo et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

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Article Biochemistry & Molecular Biology

Inhibition of yeast glycolysis by nitroxyl (HNO): A mechanism of HNO toxicity and implications to HNO biology

BE Lopez et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)

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Review Pathology

Technical aspects of immunohistochemistry

JA Ramos-Vara

VETERINARY PATHOLOGY (2005)

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