Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2016.00037
Keywords
MDSC; myeloid-derived suppressor cells; bacteria; infection; immune suppression; sepsis
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Funding
- IZKE, University of Tubingen
- Deutsches Zentrum fur infektionsforschung (DZIF)
- DFG, University of Tubingen [SFB/CRC685]
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Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.
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