Journal
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
Volume 28, Issue 1, Pages -Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/jrms.jrms_727_22
Keywords
Dinutuximab; GD2; monoclonal antibody; neuroblastoma
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Dinutuximab, a monoclonal antibody targeting GD2 in neuroblastoma, has been found to improve survival in patients. It increases event-free survival and overall survival as maintenance therapy for high-risk neuroblastoma patients. However, the use of cytokines co-administered with Dinutuximab needs further research.
Dinutuximab, which is a monoclonal antibody targeting GD2 expressed in neuroblasts, improves survival when included in the therapy regimen. This article reviews the importance of dinutuximab in managing neuroblastoma (NB). Dinutuximab targets high levels of GD2 expression in NB cells, thus increasing event-free survival when used in the maintenance therapy of high-risk patients with NB. Although several collaborative studies have set the standard of care for maintenance therapy, the long-term follow-up and continuous evaluation of the use of antibodies and the co-administration of other pharmacological or immunomodulatory drugs remain to be studied. Trials have shown that the use of dinutuximab for maintenance therapy can prolong the time before the first relapse and improve overall survival. However, there is uncertainty in the function of cytokines co-administered with dinutuximab, which may lead to increased toxicity without additional benefits. Recent studies on relapsed and refractory NB have shown the potential efficacy of dinutuximab. Further research is required to properly incorporate Dinutuximab in current treatment modalities.
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