4.6 Article

Comparison of amoxicillin administered twice and three times daily in children with acute otitis media

Journal

EUROPEAN JOURNAL OF PEDIATRICS
Volume -, Issue -, Pages -

Publisher

SPRINGER
DOI: 10.1007/s00431-023-05243-2

Keywords

Otitis; Amoxicillin; Antibiotic

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This study compared the efficacy of amoxicillin administered twice or three times daily in children with acute otitis media, and measured and compared treatment adherence between the two groups. The results showed that twice-daily amoxicillin had similar efficacy to a three-dose daily regimen and offered advantages in terms of administration schedule for caregivers.
To compare the effectiveness of amoxicillin administered in regimens of two or three daily doses in children with acute otitis media (AOM). As a secondary aim, we measured and compared treatment adherence between the two groups.A prospective observational study was conducted in the emergency department of a children's hospital.We recruited a total of 353 patients having a median age of 1.58 years. Twice-daily dosing was prescribed to 58%, while 42% received three doses per day. The clinical course of AOM was favourable in 92% of the patients who received two doses of amoxicillin and in 95% of those who received three doses (p = 0.25). Four patients (1%) had persistent symptoms beyond day 7. None developed intracranial complications. In the group receiving three doses daily, 31% reported difficulties with the dosing schedule, and 9.6% faced challenges when administering the medication at the specified volume, compared with 5.8% and 25% of those who received the two-dose regimen, respectively. Conclusion: Twice-daily amoxicillin has similar efficacy to a three-dose daily regimen and can offer advantages for caregivers in terms of administration schedule.What is Known:center dot Amoxicillin given in two daily doses is as effective as a three doses regimen in the treatment of acute otitis media in children.center dot The lower the number of daily doses, the higher the adherence to a drug treatment.What is New:center dot Administration of amoxicillin in twice-daily doses may improve adherence, as it is less frequently associated with family-perceived problems with dosing schedules.

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