Efferocytosis and Respiratory Disease

Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis. If the process fails, this may cause different types of diseases. More and more evidence suggests that a faulty efferocytosis process is closely related to the pathological processes of respiratory diseases. In this review, we will first introduce the process and the related mechanisms of efferocytosis of the macrophage. Secondly, we will propose some methods that can regulate the function of efferocytosis at different stages of the process. Next, we will discuss the role of efferocytosis in different lung diseases and the related treatment approaches. Finally, we will summarize the drugs that have been applied in clinical practice that can act upon efferocytosis, in order to provide new ideas for the treatment of lung diseases.

Automated summary

Cells are the fundamental units of living organisms and undergo processes like proliferation and differentiation. Dead cells need to be removed through efferocytosis to maintain organism homeostasis. This review explores the relevance of faulty efferocytosis in respiratory diseases, discussing the process, mechanisms, regulation methods, and treatment approaches. Additionally, it summarizes drugs that target efferocytosis for potential treatment of lung diseases.