The oral administration of Lotus corniculatus L. attenuates acute and chronic pain models in male rats

Article Plant Sciences

Thymus persicus (Ronniger ex Rech. f.) Jalas alleviates nociceptive and neuropathic pain behavior in mice: Multiple mechanisms of action

Donya Ziafatdoost Abed et al.

Summary: The essential oil of Thymus persicus showed strong antinociceptive and anti-neuropathic effects in Swiss mice, involving various signaling pathways and receptors.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Anesthesiology

Mechanisms of injustice: what we (do not) know about racialized disparities in pain

Vani A. Mathur et al.

PAIN (2022)

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Article Chemistry, Medicinal

Kaempferol exerts a neuroprotective effect to reduce neuropathic pain through TLR4/NF-kappa B signaling pathway

Shiquan Chang et al.

Summary: This research demonstrates that kaempferol has anti-inflammatory and analgesic effects, potentially through modulating microglial polarization and inhibiting the TLR4/NF-kappa B signaling pathway.

PHYTOTHERAPY RESEARCH (2022)

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Article Plant Sciences

Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil

Donya Ziafatdoost Abed et al.

Summary: The seeds essential oil of Descurainia sophia exhibits anti-nociceptive and antineuropathic activities, possibly by modulating multiple channel pathways and receptors.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Food Science & Technology

Encapsulated essential oils: A perspective in food preservation

Douglas Rodrigues Reis et al.

Summary: Due to their antioxidant and antimicrobial properties, essential oils have seen a high demand in recent decades. However, their incorporation into low-fat foods is challenging due to their hydrophobic nature, strong aroma, and flavor. Encapsulation has emerged as an effective solution to overcome these issues. This review discusses the current techniques for encapsulating essential oils, including emulsion-based delivery systems and membrane emulsification.

FUTURE FOODS (2022)

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Article Chemistry, Applied

Phytochemical and pharmacological appraisal of the aerial parts ofLotus corniculatusL. growing in Egypt

Rokia M. Abdallah et al.

Summary: Lotus corniculatus L., widely grown in Egypt, has a rich history of folkloric medicinal uses. Extracts from its aerial parts showed significant antioxidant and immunostimulant activities, as well as antifungal and antiprotozoal activities against various pathogens. Multiple compounds were isolated from the plant through this study.

NATURAL PRODUCT RESEARCH (2021)

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Article Plant Sciences

Artemisia biennis Willd.: Anti-Nociceptive effects and possible mechanisms of action

Mohammad Zarei et al.

Summary: Artemisia biennis Willd. (known as Dermane in Persian) has been traditionally used as an antinociceptive remedy in Iranian folk medicine. The essential oil from the aerial parts of Artemisia biennis Willd. showed significant anti-nociceptive effects in male Swiss mice, possibly by modulating glutamatergic mechanisms via opioid systems. Additionally, ABAEO demonstrated potent analgesic effects in thermal pain models and alleviated mechanical allodynia in mice.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Bupleurum falcatum L. alleviates nociceptive and neuropathic pain: Potential mechanisms of action

Davoud Ahmadimoghaddam et al.

Summary: In Iranian folkloric medicine, Bupleurum falcatum L. has been used as a selective analgesic remedy. The research investigated the anti-nociceptive and anti-allodynic action of Bupleurum falcatum L. roots essential oil in Swiss mice. Results showed that BFEO exhibited significant antinociceptive effects and could effectively alleviate allodynia in CSC mice by activating specific pathways and receptors.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Neurosciences

The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review

Xia-qing Wang et al.

Summary: Chronic pain is a societal economic burden often managed with opioids, which can lead to tolerance and hyperalgesia. Dopamine receptors, particularly D2 receptors, play a crucial role in pain modulation, with D1 receptors acting differently across various mechanisms. Targeting D2 receptors can enhance analgesic effects and provide a better approach to pain relief.

NEURAL PLASTICITY (2021)

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Article Neurosciences

Cervical spinal cord injury-induced neuropathic pain in male mice is associated with a persistent pro-inflammatory macrophage/microglial response in the superficial dorsal horn

Eric Brown et al.

Summary: The study revealed significant MM phi heterogeneity within and across pain transmission locations after SCI, including a prominent pro-inflammatory MM phi response in the sDH of cervical spinal cord. These data suggest a possible role for MM phi in DH neuron hyperexcitability and NP.

EXPERIMENTAL NEUROLOGY (2021)

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Article Clinical Neurology

Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway

Guangyao Ye et al.

Summary: Quercetin alleviates neuropathic pain in rats with chronic constriction injury by activating the AMPK pathway and inhibiting the MAPK pathway and its downstream targets, thus reducing inflammation and improving pain threshold.

JOURNAL OF PAIN RESEARCH (2021)

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Article Medicine, Research & Experimental