Journal
FOOD & NUTRITION RESEARCH
Volume 60, Issue -, Pages -Publisher
SWEDISH NUTRITION FOUNDATION-SNF
DOI: 10.3402/fnr.v60.32033
Keywords
low-molecular-weight fucoidan; fucoxanthin; anti-inflammatory; prebiotics
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Funding
- National Science Council (NSC) of the Executive Yuan, Taiwan [NSC 104-2320-B-034-003, NSC 105-2320-B-034-001]
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Background: The aim of this study is to investigate the anti-inflammatory effects of low-molecular-weight fucoidan (LMF) and high-stability fucoxanthin (HS-Fucox) in a lipopolysaccharide-induced inflammatory Caco-2 cell line co-culture with B. lactis. Methods: We used various methods such as transepithelial resistance (TER) assay, cytokine secretion assay, and tight junction protein mRNA expression assay to examine LMF and HS-Fucox anti-inflammatory properties. Results: LMF and HS-Fucox activated probiotic growth and reduced the inflammation of the intestinal epithelial cells. Moreover, the combination of LMFHS-Fucox dramatically enhanced the intestinal epithelial barrier and immune function against the lipopolysaccharide effect by inhibiting IL-1 beta and TNF-alpha and promoting IL-10 and IFN-gamma. Conclusion: These findings suggested that LMF and HS-Fucox, alone or in combination, could be the potential natural compounds to enhance the immune system and have an anti-inflammatory effect on the intestinal cells.
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