☆ 4.8 Review

Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells

FRONTIERS IN IMMUNOLOGY (2023)

Related references

Note: Only part of the references are listed.
Article Neurosciences

TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection

Yuanyuan Wang et al.

Summary: Disability in multiple sclerosis (MS) is partially caused by the failure of remyelination and progressive neurodegeneration. The role of microglia, especially triggering receptor expressed on myeloid cells 2 (TREM2), in remyelination is significant. In this study, using a mouse model of focal demyelination, we found that TREM2 knockout mice had persistent demyelination and subsequent neurodegeneration lasting more than 6 weeks. Furthermore, TREM2 knockout microglia showed defects in migration and phagocytosis of myelin debris.

GLIA (2023)

Add to Collection
Article Clinical Neurology

The insula modulates the effects of aerobic training on cardiovascular function and ambulation in multiple sclerosis

Matteo Albergoni et al.

Summary: This study investigated the association between damage to the insula and cardiovascular fitness (CF) in patients with multiple sclerosis (MS). The results showed that aerobic training (AT) may improve walking capacity and submaximal measure of CF in MS patients, and this beneficial effect may be modulated by insula integrity.

JOURNAL OF NEUROLOGY (2023)

Add to Collection
Review Neurosciences

Exercise-induced modulation of neuroinflammation in ageing

Zsuzsanna Barad et al.

Summary: Optimal performance of the central nervous system depends on communication between different cell types. Ageing is associated with CNS disequilibrium, but endurance exercise can have a positive impact on neuroimmune communications. Regular aerobic exercise provides an adaptive advantage against perturbations to homeostasis.

JOURNAL OF PHYSIOLOGY-LONDON (2023)

Add to Collection
Article Genetics & Heredity

The gut microbiota in multiple sclerosis varies with disease activity

Florence Thirion et al.

Summary: This study found significant differences in the gut microbiota of patients with multiple sclerosis, which are directly associated with inflammation markers. In treatment-naive cases, the bacterial richness is positively linked to disease activity. However, two symbiotic bacterial species that produce beneficial immune-modulating compounds were found in non-disease-active cases, providing a rationale for testing these bacteria as adjunct therapeutics in future clinical trials.

GENOME MEDICINE (2023)

Add to Collection
Article Clinical Neurology

Brain-derived neurotrophic factor, neurofilament light and glial fibrillary acidic protein do not change in response to aerobic training in people with MS-related fatigue - a secondary analysis of a randomized controlled trial

Arianne S. Gravesteijn et al.

Summary: In the TREFAMS-AT study, it was found that aerobic exercise therapy did not result in significant changes in neuro-specific blood-based biomarkers (BDNF, NfL, and GFAP) in people with MS.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2023)

Add to Collection
Article Cell Biology

Moderate exercise induces trained immunity in macrophages

Mayoorey Murugathasan et al.

Summary: Exercise can modify the metabolism and epigenetic genome of bone marrow-derived macrophages (BMDMs), leading to suppression of inflammatory responses. The study found that chronic moderate training can decrease NF-κB activation and proinflammatory gene expression in BMDMs stimulated with bacterial components, while increasing the expression of M2-like-associated genes. This is accompanied by improved mitochondrial quality and reduced production of reactive oxygen species. These findings suggest that exercise influences the inflammatory responses of macrophages by reprogramming their metabolism and epigenetic genome.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2023)

Add to Collection
Review Biochemistry & Molecular Biology

Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting

Marc Charabati et al.

Summary: Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system. Neuroimmune interactions play a key role in MS pathology and offer potential targets for therapy. This review explores risk factors, pathogenesis mechanisms, current therapies, and emerging technologies for addressing clinical needs.

CELL (2023)

Add to Collection
Article Biochemistry & Molecular Biology

Defective Induction of IL-27-Mediated Immunoregulation by Myeloid DCs in Multiple Sclerosis

Felipe von Glehn et al.

Summary: The study examined whether myeloid dendritic cells (mDCs) from multiple sclerosis (MS) patients and healthy controls (HCs) become similarly tolerogenic when exposed to IL-27. The results showed that mDCs from HCs but not untreated MS patients became functionally tolerogenic after IL-27 treatment. Gene expression analysis identified different responses to IL-27 between HCs and MS patients, suggesting potential targets for regulating mDC tolerogenic responses.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection
Article Immunology

TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair

Jinghui Xu et al.

Summary: This study found that moderate physical exercise (PE) promotes remyelination and improves neurological function in rats with transient middle cerebral artery occlusion (tMCAO). PE exerted neuroprotective effects by modulating microglial state and promoting remyelination. This regenerative role of PE is mediated by upregulation of TREM2 and microglia-derived factor for oligodendrocytes regeneration.

JOURNAL OF NEUROINFLAMMATION (2023)

Add to Collection
Article Biochemical Research Methods

Exercise Alleviates Behavioral Disorders but Shapes Brain Metabolism of APP/PS1 Mice in a Region- and Exercise-Specific Manner

Na Ying et al.

Summary: Exercise, including high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), can improve behavioral and cognitive impairments in Alzheimer's disease (AD) mice. Metabolomics analysis reveals significant changes in energy metabolism, neurotransmitter metabolism, and membrane metabolism in multiple brain regions after both types of exercises. HIIT also alters astrocyte-neuron metabolism in the hippocampus and hypothalamus of AD mice. These findings suggest that exercise can modulate brain metabolism in a region- and exercise-specific manner, potentially providing a novel approach for the prevention and treatment of AD.

JOURNAL OF PROTEOME RESEARCH (2023)

Add to Collection
Review Neurosciences

Roles and regulation of microglia activity in multiple sclerosis: insights from animal models

Felix Distefano-Gagne et al.

Summary: This article discusses the mechanisms through which microglia contribute to neuropathology and the molecular mechanisms that regulate their function in demyelinating conditions. Microglia, as resident macrophages of the CNS, play critical roles in inflammatory lesions and associated neural dysfunctions. They have both detrimental effects on myelin and beneficial effects on tissue repair, and recent advances have shed light on their underlying molecular effectors.

NATURE REVIEWS NEUROSCIENCE (2023)

Add to Collection
Article Multidisciplinary Sciences

Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming

Kuniyuki Aso et al.

Summary: The study reveals that itaconate can alter T cell function and impact the development of autoimmune diseases through modulation of metabolic and epigenetic programs. Itaconate inhibits Th17 cell differentiation and promotes Treg cell differentiation by suppressing glycolysis and oxidative phosphorylation. The metabolic changes induced by itaconate also affect chromatin accessibility, transcription factor binding, and gene expression in Th17 and Treg cell differentiation. Furthermore, the adoptive transfer of itaconate-treated Th17 cells can ameliorate autoimmune encephalomyelitis. These findings suggest that itaconate is a crucial metabolic regulator for Th17/Treg cell balance and can be a potential therapeutic agent for autoimmune diseases.

NATURE COMMUNICATIONS (2023)

Add to Collection
Article Multidisciplinary Sciences

Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown

Sidar Aydin et al.

Summary: Blood-brain barrier breakdown and immune cell infiltration are early markers of multiple sclerosis. Researchers have found that brain endothelial cells cross-present antigen to CD8(+) T cells, preventing their migration and initiating blood-brain barrier breakdown.

NATURE COMMUNICATIONS (2023)

Add to Collection
Article Multidisciplinary Sciences

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration

Irene Molina-Gonzalez et al.

Summary: Failed regeneration of myelin around neuronal axons following central nervous system damage contributes to nerve dysfunction and clinical decline in various neurological conditions. This study shows that the interaction between astrocytes and mature myelin-forming oligodendrocytes is crucial for remyelination. Astrocytes support the survival of regenerating oligodendrocytes by downregulating the Nrf2 pathway and activating the cholesterol biosynthesis pathway. This discovery reveals a drug strategy for central nervous system regeneration by targeting the astrocyte-oligodendrocyte interaction.

NATURE COMMUNICATIONS (2023)

Add to Collection
Article Immunology

The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage

Rui-Hong Wang et al.

Summary: The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI) were compared for their predictive value for stroke-associated pneumonia (SAP) in patients with intracerebral hemorrhage (ICH). The NLR was found to be the best predictor for SAP occurrence and ICU admission, as well as for the outcome at discharge in ICH patients.

FRONTIERS IN IMMUNOLOGY (2023)

Add to Collection
Article Clinical Neurology

Influence of exercise on quantity and deformability of immune cells in multiple sclerosis

Undine Proschmann et al.

Summary: The study investigated the effect of exercise on immune cell count and cell mechanical properties in people with multiple sclerosis (pwMS) on different disease-modifying treatments (DMT) compared to healthy controls (HCs). Different exercise paradigms were used, and blood samples were collected before and after exercise to analyze immune cell subtypes and lymphocyte deformability. The results showed that exercise increased lymphocyte counts and immune cell subsets in both pwMS and HCs, while lymphocyte deformability was minimally affected.

FRONTIERS IN NEUROLOGY (2023)

Add to Collection
Article Biochemistry & Molecular Biology

Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation

Wei Sun et al.

Summary: This study found that ketogenic diet (KD) can reduce motor impairment, suppress demyelination, improve pathological lesions, inhibit microglial activation, and mitigate inflammation in an experimental autoimmune encephalomyelitis (EAE) mouse model. The KD also modulates the inflammatory environment, reduces inflammatory cell infiltration, and inhibits NLRP3 activation. These effects are mediated through the modulation of various signaling pathways.

FOOD & FUNCTION (2023)

Add to Collection
Review Immunology

Microglia regulation of central nervous system myelin health and regeneration

Sarah A. Kent et al.

Summary: This article reviews the role of microglia in the maintenance and regeneration of myelin, which is damaged in normal aging and neurodegenerative diseases. Microglia, as resident macrophages of the central nervous system, have key functions in development, homeostasis, and response to damage and infection. Understanding the mechanisms by which microglia support and restore myelin health is essential for identifying potential therapeutic approaches for myelin-related diseases.

NATURE REVIEWS IMMUNOLOGY (2023)

Add to Collection
Article Medicine, Research & Experimental

High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization

Shu Feng et al.

Summary: This study found that high-intensity interval training (HIIT) can improve Alzheimer's disease-like pathology by regulating astrocyte phenotype and astrocyte phenotype-associated AQP4 polarization, promoting the clearance of Alzheimer's disease-related proteins.

THERANOSTICS (2023)

Add to Collection
Review Biochemistry & Molecular Biology

T cells in health and disease

Lina Sun et al.

Summary: T cells play a crucial role in maintaining immune functions and preventing diseases. They differentiate into CD4(+) helper and CD8(+) cytotoxic effector and memory cells, which regulate immune responses and provide long-term protection. In response to infections and tumors, T cells develop into heterogeneous populations with various functions under precise regulation of transcriptional and epigenetic programs. Abnormal T-cell immunity can lead to autoimmune diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Add to Collection
Review Pathology

The Immune Response in Multiple Sclerosis

Sofia Rodriguez Murua et al.

Summary: Multiple sclerosis is a chronic disease affecting the central nervous system, characterized by immune dysregulation and resulting in demyelination, neuronal damage, and degeneration. Genetic and environmental factors are believed to play a role in the onset and progression of this disease.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

Add to Collection
Article Cardiac & Cardiovascular Systems

Exercise Training Protects Against Heart Failure Via Expansion of Myeloid-Derived Suppressor Cells Through Regulating IL-10/STAT3/S100A9 Pathway

Lifeng Feng et al.

Summary: This study found that ET can increase MDSCs by stimulating the secretion of IL-10 from macrophages, thereby achieving the role of heart protection. This effect is mediated through the IL-10/STAT3/S100A9 signaling pathway to regulate the differentiation of MDSCs.

CIRCULATION-HEART FAILURE (2022)

Add to Collection
Review Immunology

Imaging dendritic cell functions

Berislav Bosnjak et al.

Summary: Dendritic cells (DCs) play a crucial role in initiating adaptive immune responses by capturing antigens during inflammation and inducing tolerance under non-inflammatory conditions. Understanding DC biology is essential for vaccine development and autoimmune disease prevention. Bioimaging tools are crucial for tracking DCs in tissues and organs and visualizing subcellular and molecular processes.

IMMUNOLOGICAL REVIEWS (2022)

Add to Collection
Article Physiology

Resistance-exercise training attenuates LPS-induced astrocyte remodeling and neuroinflammatory cytokine expression in female Wistar rats

Taylor J. Kelty et al.

Summary: Resistance-exercise training in rats can improve cognition and reduce lipopolysaccharide-induced neuroinflammation, demonstrating an anti-inflammatory effect in the brain.

JOURNAL OF APPLIED PHYSIOLOGY (2022)

Add to Collection
Article Immunology

Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice

Shan-shan Zhang et al.

Summary: The role of physical exercise in the prevention and treatment of Alzheimer's disease (AD) has been investigated in a study on mice. Voluntary running improved cognitive function and promoted brain glucose metabolism and microglial metabolic activity. Running exercise also enhanced the morphology and proliferation of microglia.

JOURNAL OF NEUROINFLAMMATION (2022)

Add to Collection
Review Immunology

Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics

Emily Kamma et al.

Summary: There are limited treatment options available for progressive multiple sclerosis (MS) due to a poor understanding of its pathophysiology. Microglia and macrophages play a vital role in the progressive phase of MS and may contribute to neurodegeneration. However, there is a lack of disease-modifying drugs that target these cells specifically in progressive MS.

JOURNAL OF NEUROINFLAMMATION (2022)

Add to Collection
Review Clinical Neurology

The role of glial cells in multiple sclerosis disease progression

Luke M. Healy et al.

Summary: This Review discusses the involvement of astrocytes and microglia in the pathophysiology of progressive multiple sclerosis and considers current and future therapeutic approaches targeting glial cells. Greater understanding of the roles of these cells is needed to identify novel therapeutic opportunities for progressive MS.

NATURE REVIEWS NEUROLOGY (2022)

Add to Collection
Article Medicine, General & Internal

Alterations of host-gut microbiome interactions in multiple sclerosis

Claudia Cantoni et al.

Summary: This study conducted a six-month longitudinal multi-omics study on multiple sclerosis (MS) patients and healthy controls, revealing multi-system alterations in gut microbiota, immune system, and blood metabolome. The study demonstrated the interactions between gut microbiome and host immune system, metabolism, and diet, and identified microbiome and metabolome features related to the degree of disability in MS patients. Furthermore, a correlation network linking meat intake with gut microbiota and blood metabolites was discovered.

EBIOMEDICINE (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Neuroinflammation Is Associated with GFAP and sTREM2 Levels in Multiple Sclerosis

Federica Azzolini et al.

Summary: The study found that GFAP and sTREM-2 are suitable biomarkers for central inflammation in multiple sclerosis (MS) and are associated with certain inflammatory factors and clinical characteristics. Enhanced CSF expression of GFAP may indicate a higher risk of progression in patients.

BIOMOLECULES (2022)

Add to Collection
Article Neurosciences

Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis

Mei-xi Liu et al.

Summary: Exercise training post-ischemic stroke can reduce neuroinflammation by suppressing inflammasome-mediated pyroptosis and shifting microglial polarization towards a neuroprotective M2 phenotype.

EXPERIMENTAL NEUROLOGY (2022)

Add to Collection
Article Clinical Neurology

Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis: The Early Multiple Sclerosis Exercise Study (EMSES)

Morten Riemenschneider et al.

Summary: Early supervised aerobic exercise did not reduce relapse rate or global brain atrophy in patients with MS, but it positively affected the microstructural integrity of important motor-related tracts and nuclei.

MULTIPLE SCLEROSIS JOURNAL (2022)

Add to Collection
Article Chemistry, Medicinal

Discovery of new macrophage M2 polarization modulators as multiple sclerosis treatment agents that enable the inflammation microenvironment remodeling

Jinxin Che et al.

Summary: The new macrophage M2 polarization modulator B9 was found to have high activity in promoting M2 polarization and significantly improving symptoms in EAE mice.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection
Article Neurosciences

Protective effects of treadmill exercise on apoptotic neuronal damage and astrocyte activation in ovariectomized and/or diabetic rat prefrontal cortex: molecular and histological aspects

Zohreh Zare et al.

Summary: The study found that physical exercise could protect against neuronal damage in the prefrontal cortex induced by diabetes.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2022)

Add to Collection
Review Immunology

Impact of disease-modifying therapy on dendritic cells and exploring their immunotherapeutic potential in multiple sclerosis

Caiyun Liu et al.

Summary: Dendritic cells (DCs) play a crucial role in autoimmune diseases such as multiple sclerosis (MS) and can be significantly affected by current disease-modifying therapies (DMT). The induction of tolerogenic DCs (tolDCs) has shown therapeutic potential in laboratory models and early clinical trials. Targeting specific cell-surface receptors to induce tolDCs in vivo has greater promise and advantages compared to in vitro induction.

JOURNAL OF NEUROINFLAMMATION (2022)

Add to Collection
Article Multidisciplinary Sciences

A microbiome-dependent gut-brain pathway regulates motivation for exercise

Lenka Dohnalova et al.

Summary: This study discovered a gut-brain connection in mice that enhances exercise performance by increasing dopamine signaling during physical activity. The researchers found that gut microbiota-dependent production of endocannabinoid metabolites stimulates sensory neurons, elevating dopamine levels, and improving running capacity. These findings have significant implications for understanding exercise motivation and interindividual differences in exercise performance.

NATURE (2022)

Add to Collection
Review Clinical Neurology

Contribution of B cells to cortical damage in multiple sclerosis

Pavan Bhargava et al.

Summary: This article reviews the role of B cells in mediating cortical demyelination and neuronal damage in multiple sclerosis. The authors summarize the evidence linking B cells to cortical injury, potential mechanisms by which B cells may mediate oligodendrocyte and neuronal death, and treatment strategies that could be used to target pathogenic B cells.

BRAIN (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Bone marrow hematopoiesis drives multiple sclerosis progression

Kaibin Shi et al.

Summary: The study reveals that bone marrow hematopoietic stem and progenitor cells (HSPCs) in multiple sclerosis patients are skewed towards myeloid lineage, while T cells undergo clonal expansion. Animal model research demonstrates a significant bone marrow myelopoiesis, offering a new avenue for treating MS.

CELL (2022)

Add to Collection
Review Geriatrics & Gerontology

The effect of resistance exercise on the immune cell function in humans: A systematic review

Lene Salimans et al.

Summary: This review provides a systematic analysis of the impact of resistance exercise on immune cells in the blood circulation. The findings suggest that resistance exercise activates specific signaling pathways in immune cells and improves antioxidant enzyme expression. Additionally, there are age-related differences in natural killer cell activity after resistance exercise.

EXPERIMENTAL GERONTOLOGY (2022)

Add to Collection
Article Immunology

Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis

Shen-zhao Lu et al.

Summary: This study reveals a previously unknown role for dopamine D2 receptor (DRD2) in astrocyte activation during central nervous system inflammation associated with experimental autoimmune encephalomyelitis (EAE). Blocking astrocytic DRD2 can inhibit the inflammatory response.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

Add to Collection
Review Biotechnology & Applied Microbiology

Thinking outside the box: non-canonical targets in multiple sclerosis

Laura Bierhansl et al.

Summary: This article highlights five non-canonical targets in preclinical MS research: oligodendrocytes; the blood-brain barrier; metabolites and cellular metabolism; the coagulation system; and tolerance induction. Recent findings in these areas may guide the field towards novel targets for future therapeutic approaches in MS.

NATURE REVIEWS DRUG DISCOVERY (2022)

Add to Collection
Review Clinical Neurology

The role of the gut microbiota in multiple sclerosis

Jorge Correale et al.

Summary: Research in the past decade has shown that the gut microbiota, a community of microorganisms in the gut, is closely linked to human health and disease, particularly in terms of immune responses. This review examines the impact of the gut microbiota on immune function by influencing serotonin production in the gut and interacting with components of the immune system like T cells and B cells. The authors present evidence from studies in mice and humans that the gut microbiota plays an important role in the development and course of multiple sclerosis. They also discuss strategies, such as probiotics, bacterial metabolite supplementation, fecal transplantation, and dietary intervention, for manipulating the gut microbiota to address immune dysfunction related to the disease.

NATURE REVIEWS NEUROLOGY (2022)

Add to Collection
Article Psychology, Biological

Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer's disease model

Linlin Zhang et al.

Summary: This study demonstrates that physical exercise improves cognitive function in an Alzheimer's disease model by activating the TREM2 pathway, inhibiting microglial activation, and reducing neuroinflammation.

PHYSIOLOGY & BEHAVIOR (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Physical Exercise Promotes DNase Activity Enhancing the Capacity to Degrade Neutrophil Extracellular Traps

Anna S. Ondracek et al.

Summary: Regular physical activity can improve cardiovascular health by increasing DNase activity to lower pro-inflammatory signaling, complementing measures of primary and secondary prevention.

BIOMEDICINES (2022)

Add to Collection
Article Immunology

Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation

Antoinette G. Naeem et al.

Summary: The study suggests the potential neuroprotective effect of Nebivolol in the Cup-induced model of multiple sclerosis in mice. Nebivolol may protect against demyelination and neuroinflammation by modulating microglial activation, inhibiting the NLRP3/caspase-1/IL-18 inflammatory cascade, and alleviating oxidative stress.

INFLAMMOPHARMACOLOGY (2022)

Add to Collection
Article Medicine, General & Internal

Immune aging in multiple sclerosis is characterized by abnormal CD4 T cell activation and increased frequencies of cytotoxic CD4 T cells with advancing age

Leah Zuroff et al.

Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.

EBIOMEDICINE (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

Sergio E. Baranzini et al.

Summary: The study found that the gut microbiome of multiple sclerosis patients is different from that of healthy controls. Specific microbial changes were observed in untreated MS patients. The therapeutic activity of interferon-b may be associated with upregulation of short-chain fatty acid transporters. These findings suggest a close association between the gut microbiome and multiple sclerosis risk, progression, and treatment response.

CELL (2022)

Add to Collection
Article Neurosciences

Preventive exercise attenuates IL-2-driven mood disorders in multiple sclerosis

Luana Gilio et al.

Summary: Exercise has an immunomodulatory effect in MS patients, reducing levels of proinflammatory cytokines and improving mood disorders. IL-2 plays a causal role in mood disorders and synaptic dysfunction in MS. Further studies are needed to investigate the long-term effects of exercise as a disease-modifying therapy in MS.

NEUROBIOLOGY OF DISEASE (2022)

Add to Collection
Article Multidisciplinary Sciences

NAD(+) metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity

Tom Meyer et al.

Summary: This study reveals that NAD(+) generation via the salvage pathway regulates immune function of astrocytes. CD38, as the main NADase, is up-regulated in reactive astrocytes in models of neuroinflammation and MS. Inhibition of CD38 activity increases NAD(+) levels, suppresses proinflammatory transcriptional reprogramming, impairs chemotactic potential to inflammatory monocytes, and ameliorates EAE.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection
Article Immunology

Sustained Infiltration of Neutrophils Into the CNS Results in Increased Demyelination in a Viral-Induced Model of Multiple Sclerosis

Dominic D. Skinner et al.

Summary: By characterizing the molecular and cellular changes in transgenic mice, this study reveals the changes in the profile of neutrophils associated with increased white matter damage in mice persistently infected with a neurotropic coronavirus.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection
Article Clinical Neurology

Exercise training alters autoimmune cell invasion into the brain in autoimmune encephalomyelitis

Liel Hamdi et al.

Summary: This study found that high-intensity continuous training (HICT) can attenuate the development of autoimmune neuroinflammation through immunomodulatory and neuroprotective effects. HICT inhibits the migratory potential of autoreactive cells and reduces blood-brain barrier permeability, leading to reduced inflammation.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2022)

Add to Collection
Review Clinical Neurology

Role of B Cells in Multiple Sclerosis and Related Disorders

Giancarlo Comi et al.

Summary: Selective B-cell depletion in patients with relapsing multiple sclerosis and primary progressive MS has led to a conceptual shift in understanding the pathogenesis of MS, highlighting the essential role of B cells in both inflammatory and neurodegenerative components of the disease.

ANNALS OF NEUROLOGY (2021)

Add to Collection
Article Clinical Neurology

High-intensity interval training reduces neutrophil-to-lymphocyte ratio in persons with multiple sclerosis during inpatient rehabilitation

Niklas Joisten et al.

Summary: The study indicates that high-intensity interval training (HIIT) can reduce the neutrophil-to-lymphocyte ratio (NLR) in patients with multiple sclerosis, possibly through repetitive inflammatory states and compensatory anti-inflammatory effects after each HIIT session.

MULTIPLE SCLEROSIS JOURNAL (2021)

Add to Collection
Review Immunology

Cytokine Regulation and Function in T Cells

Chen Dong

Summary: T lymphocytes play a key role in cellular immunity, with significant heterogeneity in CD4(+) T cells leading to the identification of various subsets with unique roles in immunity and pathology. Understanding cytokine regulation and function has provided innovative treatment options for many human diseases.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

Add to Collection
Article Immunology

Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis

Francesca Romana Rizzo et al.

Summary: Exercise is recommended as a beneficial supportive therapy for people with MS, improving motor disability and pathological features. Chronic voluntary exercise has positive effects on motor disability, cognition, and hippocampal damage in an animal model of MS, by reducing inflammation, promoting synaptic plasticity, and protecting neurons. Overall, regular exercise improves cognitive function and brain pathology in EAE/MS.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Add to Collection
Article Multidisciplinary Sciences

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

Joon-Hyuk Lee et al.

Summary: This study demonstrates that astrocytes in the adult hippocampus carry out phagocytosis through MEGF10 to maintain proper synaptic connectivity and plasticity. The findings reveal the crucial role of astrocytes in the activity-dependent elimination of excitatory synapses, highlighting the importance of this astrocytic function in supporting cognitive function.

NATURE (2021)

Add to Collection
Article Clinical Neurology

Continuous and interval training attenuate encephalomyelitis by separate immunomodulatory mechanisms

Yehuda Goldberg et al.

Summary: Both HICT and HIIT attenuate systemic autoimmunity and T cell encephalitogenicity by distinct immunomodulatory mechanisms. HICT inhibited PLP-induced T-cell proliferation while HIIT inhibited polarization of T cells into T-helper 1 and T-helper 17 autoreactive populations.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

Add to Collection
Review Immunology

Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation

Marco Prinz et al.

Summary: The immune system of the CNS is primarily made up of specialized macrophages, which are found in both the parenchyma and CNS interfaces. These brain-resident cells are considered the most suitable targets for modulating CNS diseases, as they are plastic, long-lived, and carry a large number of risk genes for various pathologies.Recent single-cell technologies have enhanced our understanding of their molecular characteristics and functional cell states during health and perturbation.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

Add to Collection
Article Neurosciences

Effect of low-intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer's disease

Kazuki Nakanishi et al.

Summary: This study found that low-intensity motor balance and coordination exercise prevented age-related cognitive decline in the early stage of Alzheimer's disease progression. This type of exercise may work by suppressing hippocampal A beta deposition, neuronal loss, oxidative stress, and neuroinflammation, including reduced M1 and A1 phenotypes microglia and astrocytes.

EXPERIMENTAL NEUROLOGY (2021)

Add to Collection
Article Neurosciences

Activated microglia drive demyelination via CSF1R signaling

Dave E. Marzan et al.

Summary: The activated microglia play a crucial role in demyelination, with CSF1 signaling being implicated in these events.

GLIA (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice

Zhongmeng Lai et al.

Summary: Surgery-induced cognitive dysfunction in adult mice can be improved by low intensity exercise, which reduces neuroinflammation and promotes gut microbiota diversity. The exercise effects on learning and memory were also present in non-exercise mice receiving feces from exercise mice. Valeric acid, a gut microbiota product, worsens neuroinflammation, learning, and memory in mice with surgery, but exercise reduced its levels in the blood. This study suggests that gut microbiota alteration plays a role in POCD development and exercise may have potential therapeutic benefits for brain health in the presence of insults like surgery.

MOLECULAR PSYCHIATRY (2021)

Add to Collection
Review Medicine, General & Internal

Diagnosis and Treatment of Multiple Sclerosis A Review

Marisa P. McGinley et al.

Summary: Multiple sclerosis is a neurodegenerative disease that affects the central nervous system, leading to physical disability, cognitive impairment and decreased quality of life. Current disease-modifying therapies can reduce relapse rates by 29% to 68% compared to placebo or active comparators.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Bilirubin nanomedicine ameliorates the progression of experimental autoimmune encephalomyelitis by modulating dendritic cells

Tae Woo Kim et al.

Summary: BRNPs have shown potential in delaying disease onset, suppressing disease progression and severity, and reducing disease incidence rate in the EAE mouse model, without the need for systemic immunosuppression. Studies have found that BRNPs negatively regulate the differentiation of naive CD4(+) T cells into Th17 cells by scavenging reactive oxygen species.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection
Review Neurosciences

Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin et al.

Summary: The article highlights the challenges and uncertainties surrounding reactive astrocytes, advocating for comprehensive research that includes assessment of multiple molecular and functional parameters, preferably in vivo, along with multivariate statistics and determination of impact on pathological hallmarks in relevant models.

NATURE NEUROSCIENCE (2021)

Add to Collection
Article Multidisciplinary Sciences

Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed

Jonathan Lezmy et al.

Summary: Neuronal activity in rodents can raise intracellular calcium levels in astrocytes near myelinated axons, impacting the function of these axons and regulating information flow and neural circuit function in the brain's white matter.

SCIENCE (2021)

Add to Collection
Article Neurosciences

High-Intensity Exercise Training Protects the Brain Against Autoimmune Neuroinflammation: Regulation of Microglial Redox and Pro-inflammatory Functions

Yifat Zaychik et al.

Summary: The study shows that high-intensity continuous training can alleviate the severity of neuroinflammatory diseases, protecting the central nervous system from autoimmune damage.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Add to Collection
Article Multidisciplinary Sciences

Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling

Jiajia Wang et al.

Summary: Optineurin (OPTN) plays a crucial role in regulating dendritic cell (DC) maturation, where its deficiency leads to Jak2/Stat3 activation and IL-10 production, suppressing DC maturation and function to ameliorate autoimmune responses in mice.

NATURE COMMUNICATIONS (2021)

Add to Collection
Article Medicine, General & Internal

Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor

Pei-Xin Shen et al.

Summary: This study demonstrates the therapeutic effect of Urolithin A in an experimental autoimmune encephalomyelitis (EAE) animal model, with potential as a prospective therapeutic candidate for autoimmune diseases. The mechanism involves targeting the Aryl Hydrocarbon Receptor (AhR) and modulating signaling pathways to suppress inflammation and regulate immune cell functions at different stages of disease progression.

EBIOMEDICINE (2021)

Add to Collection
Article Cell Biology

Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis

Massimiliano Di Filippo et al.

Summary: The study reveals a possible link between IL-17A and hippocampal function, with IL-17A disrupting hippocampal long-term potentiation and showing correlation with dysfunction in EAE. Mice lacking IL-17A exhibit preserved visuo-spatial learning abilities in the presence of EAE.

CELL REPORTS (2021)

Add to Collection
Article Clinical Neurology

The effect of aerobic exercise on Neurofilament light chain and glial Fibrillary acidic protein level in patients with relapsing remitting type multiple sclerosis

Zubeyde Ercan et al.

Summary: This study demonstrated that serum GFAP and NFL levels decreased in RRMS patients after aerobic exercise, which may be promising in understanding the regulation of disease activity in MS patients by investigating the effects of aerobic exercise on individuals with RRMS and elucidating the underlying measurable biomarkers.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection
Article Integrative & Complementary Medicine

Home-based exercise training influences gut bacterial levels in multiple sclerosis

Motahare Mokhtarzade et al.

Summary: Home-based exercise has a significant impact on gut bacteria in people with multiple sclerosis, particularly on prevotella and akkermansia muciniphila counts, which may benefit MS disease pathology and course. However, the lack of changes in circulating cytokine levels following exercise suggests the involvement of mechanisms other than modulation of IL-10 and TNF-alpha levels.

COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE (2021)

Add to Collection
Article Immunology

Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota

Hao Chen et al.

Summary: Recent studies have shown that strength exercise can ameliorate disease severity and neuropathology in an animal model of multiple sclerosis, increase abundance and diversity of gut microbiota, decrease Firmicutes/Bacteroidetes ratio, and promote the growth of bacteria producing short-chain fatty acids. This indicates a protective role of strength exercise in neuroimmunomodulation effects through changes to the gut microbiome.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection
Article Neurosciences

Treadmill exercise alleviates neuronal damage by suppressing NLRP3 inflammasome and microglial activation in the MPTP mouse model of Parkinson's disease

Wei Wang et al.

Summary: The study demonstrated that treadmill exercise effectively alleviates neuronal damage in the MPTP-induced PD mouse model by inhibiting NLRP3 inflammasome and microglial activation.

BRAIN RESEARCH BULLETIN (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

Allon Wagner et al.

Summary: The study utilized the Compass algorithm in combination with single-cell RNA sequencing and flux balance analysis to reveal the link between metabolic states and functional variability of Th17 cells, validating the importance of metabolic switch for Th17 pathogenicity.

CELL (2021)

Add to Collection
Article Medicine, Research & Experimental

Effects of walking exercise training on learning and memory and hippocampal neuroimaging outcomes in MS: A targeted, pilot randomized controlled trial

Brian M. Sandroff et al.

Summary: This pilot study demonstrated promising results for treadmill walking exercise as a potential intervention for managing learning and memory impairments in multiple sclerosis patients, as well as preserving hippocampal volume.

CONTEMPORARY CLINICAL TRIALS (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Changes in leptin, serotonin, and cortisol after eight weeks of aerobic exercise with probiotic intake in a cuprizone-induced demyelination mouse model of multiple sclerosis

Donya Sajedi et al.

Summary: The study found that exercise and probiotic intake may help improve pathological factors in patients with multiple sclerosis, including reducing damage caused by inflammation.

CYTOKINE (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis

Monica Barone et al.

Summary: This study evaluated the potential of a brief high-impact multidimensional rehabilitation program in a leisure environment to influence gut microbiota, relieve MS symptoms, and improve quality of life. The program led to modulation of MS-typical dysbiosis, improved physical performance, fatigue relief, and a shift towards a more beneficial gut microbiota composition.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Article Medicine, Research & Experimental

Neuroprotective role of galantamine with/without physical exercise in experimental autoimmune encephalomyelitis in rats

Mohamed A. El-Emam et al.

Summary: The study suggests that the use of the anticholinesterase and cholinergic drug galantamine with or without exercise can effectively reduce disease scores and improve motor performance in the management of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). The drug can inhibit inflammation and apoptosis, promote remyelination of neurons, and exercise can enhance the drug's effects.

LIFE SCIENCES (2021)

Add to Collection
Article Multidisciplinary Sciences

A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis

Martina Absinta et al.

Summary: Through MRI-guided single-nucleus RNA sequencing, a diversity of glial and immune cells at the edge of demyelinated white matter lesions in multiple sclerosis (MS) have been identified, along with the definition of inflamed glial cell phenotypes in MS. The overlap of the transcriptional profile of microglia inflamed in MS with that in other neurodegenerative diseases suggests common mechanisms between primary and secondary neurodegeneration that could benefit from similar therapeutic approaches. The critical role of complement component 1q (C1q) in the activation of microglia inflamed in MS has been identified and potential therapeutic avenues, such as C1q inhibition, have been suggested for addressing chronic white matter inflammation.

NATURE (2021)

Add to Collection
Review Clinical Neurology

B cells in multiple sclerosis - from targeted depletion to immune reconstitution therapies

Maria T. Cencioni et al.

Summary: This Review discusses the roles of B cells in multiple sclerosis, highlighting the involvement of B cells in disease pathogenesis and the potential mechanisms underlying the abnormalities in B cell function in MS.

NATURE REVIEWS NEUROLOGY (2021)

Add to Collection
Article Multidisciplinary Sciences

Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes

Emanuela Colombo et al.

Summary: The study revealed that TrkB signaling in astrocytes plays a crucial role in demyelination, fostering oligodendrocyte damage and contributing to chronic demyelination in multiple sclerosis. Additionally, the neurotrophin receptor TrkB was found associated with the expression and release of copper ions during neuroinflammation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection
Article Clinical Neurology

Neutrophil-lymphocyte ratio as a marker for disability and activity in multiple sclerosis

Rasha M. Fahmi et al.

Summary: The study found that NLR levels were significantly higher in MS patients compared to controls, and NLR was significantly associated with MS disability and activity. Therefore, NLR may be utilized as a simple, rapid, and inexpensive inflammatory marker to assess disease status in MS patients.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection
Article Multidisciplinary Sciences

Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway

Zuliang Jie et al.

Summary: Microglia play a critical role in the progression of EAE by mediating noncanonical NF-κB signaling pathway, with NIK being essential for the recruitment of inflammatory T cells and monocytes in the CNS. The activation of T cell-derived cytokines and chemokines is important for the second-wave of T cell recruitment and disease progression in EAE.

SCIENCE ADVANCES (2021)

Add to Collection
Article Neurosciences

Progressive resistance exercise training and changes in resting-state functional connectivity of the caudate in persons with multiple sclerosis and severe fatigue: A proof-of-concept study

Nadine Akbar et al.

NEUROPSYCHOLOGICAL REHABILITATION (2020)

Add to Collection
Article Clinical Neurology

A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Marijn Huiskamp et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Add to Collection
Article Immunology

REGγ controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells

Lei Zhou et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Add to Collection
Article Cell Biology

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

Yan Liu et al.

CELL METABOLISM (2020)

Add to Collection
Article Neurosciences

Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis

Sergey Kalinin et al.

GLIA (2020)

Add to Collection
Article Clinical Neurology

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Khalil S. Rawji et al.

ACTA NEUROPATHOLOGICA (2020)

Add to Collection
Article Immunology

Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells

Aoife M. McGinley et al.

IMMUNITY (2020)

Add to Collection
Review Immunology

Treg cells in health and autoimmune diseases: New insights from single cell analysis

Clemens Scheinecker et al.

JOURNAL OF AUTOIMMUNITY (2020)

Add to Collection
Article Immunology

Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

Yee Ming Khaw et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Add to Collection
Review Clinical Neurology

Advances in oral immunomodulating therapies in relapsing multiple sclerosis

Tobias Derfuss et al.

LANCET NEUROLOGY (2020)

Add to Collection
Article Multidisciplinary Sciences

MAFG-driven astrocytes promote CNS inflammation

Michael A. Wheeler et al.

NATURE (2020)

Add to Collection
Article Clinical Neurology

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

Nina L. Fransen et al.

BRAIN (2020)

Add to Collection
Article Immunology

Novel phloroglucinol derivative Compound 21 protects experimental autoimmune encephalomyelitis rats via inhibiting Th1/Th17 cell infiltration

Zhe Zhao et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

Alexander Duscha et al.

CELL (2020)

Add to Collection
Review Hospitality, Leisure, Sport & Tourism

Physical exercise in the prevention and treatment of Alzheimer's disease

Adrian De la Rosa et al.

JOURNAL OF SPORT AND HEALTH SCIENCE (2020)

Add to Collection
Article Immunology

Expansion of Neutrophils and Classical and Nonclassical Monocytes as a Hallmark in Relapsing-Remitting Multiple Sclerosis

David Haschka et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection
Article Clinical Neurology

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Francesca Cignarella et al.

ACTA NEUROPATHOLOGICA (2020)

Add to Collection
Article Clinical Neurology

Molecular signature of slowly expanding lesions in progressive multiple sclerosis

Katharina Jaeckle et al.

BRAIN (2020)

Add to Collection
Review Physiology

Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders

Jeffrey J. Lochhead et al.

FRONTIERS IN PHYSIOLOGY (2020)

Add to Collection
Article Immunology

Primaquine elicits Foxp3+ regulatory T cells with a superior ability to limit CNS autoimmune inflammation

Rodolfo Thome et al.

JOURNAL OF AUTOIMMUNITY (2020)

Add to Collection
Correction Neurosciences

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles (vol 23, pg 561, 2020)

Anusha Mishra et al.

NATURE NEUROSCIENCE (2020)

Add to Collection
Review Neurosciences

The Gut-CNS Axis in Multiple Sclerosis

Atsushi Kadowaki et al.

TRENDS IN NEUROSCIENCES (2020)

Add to Collection
Article Immunology

The effect of 6 weeks of high intensity interval training on myelin biomarkers and demyelination in experimental autoimmune encephalomyelitis model

Fattaneh Farahmand et al.

JOURNAL OF NEUROIMMUNOLOGY (2020)

Add to Collection
Article Immunology

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Irina Belaya et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Add to Collection
Article Multidisciplinary Sciences

Gut microorganisms act together to exacerbate inflammation in spinal cords

Eiji Miyauchi et al.

NATURE (2020)

Add to Collection
Review Medicine, General & Internal

Impact of Exercise on Immunometabolism in Multiple Sclerosis

Remsha Afzal et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Add to Collection
Article Clinical Neurology

Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition

Clare Walton et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Add to Collection
Article Neurosciences

Voluntary wheel running stimulates the expression of Nrf-2 and interleukin-10 but suppresses interleukin-17 in experimental autoimmune encephalomyelitis

Amir Hossein Saffar Kohneh Quchan et al.

NEUROSCIENCE LETTERS (2020)

Add to Collection
Article Urology & Nephrology

Swimming Exercise Ameliorates Symptoms of MOG-Induced Experimental Autoimmune Encephalomyelitis by Inhibiting Inflammation and Demyelination in Rats

Ji-Youn Kim et al.

INTERNATIONAL NEUROUROLOGY JOURNAL (2020)

Add to Collection
Article Clinical Neurology

Effects of an individual 12-week community-located start-to-run program on physical capacity, walking, fatigue, cognitive function, brain volumes, and structures in persons with multiple sclerosis

Peter Feys et al.

MULTIPLE SCLEROSIS JOURNAL (2019)

Add to Collection
Article Clinical Neurology

Effects of an individual 12-week community-located start-to-run program on physical capacity, walking, fatigue, cognitive function, brain volumes, and structures in persons with multiple sclerosis

Peter Feys et al.

MULTIPLE SCLEROSIS JOURNAL (2019)

Add to Collection
Article Cell Biology

Exercise rescues the immune response fine-tuned impaired by peroxisome proliferator-activated receptors deletion in macrophages

Loreana Sanches Silveira et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Add to Collection
Article Clinical Neurology

Gut microbiota-dependent CCR9 + CD4 + T cells are altered in secondary progressive multiple sclerosis

Atsushi Kadowaki et al.

BRAIN (2019)

Add to Collection
Article Immunology

Effects of moderate- versus high- intensity swimming training on inflammatory and CD4+ T cell subset profiles in experimental autoimmune encephalomyelitis mice

Yu Xie et al.

JOURNAL OF NEUROIMMUNOLOGY (2019)

Add to Collection
Review Immunology

Blood-brain barrier permeability and physical exercise

Marta A. Malkiewicz et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Add to Collection
Article Immunology

Myelin oligodendrocyte glycoprotein revisited-sensitive detection of MOG-specific T-cells in multiple sclerosis

Mattias Bronge et al.

JOURNAL OF AUTOIMMUNITY (2019)

Add to Collection
Article Anesthesiology

Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis

Yuka Harada et al.

PAIN (2019)

Add to Collection
Article Geriatrics & Gerontology

Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PSI Mice, Possibly via Hippocampal Microglia Modifications

Xianliang Zhang et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Add to Collection
Review Physiology

MYELIN IN THE CENTRAL NERVOUS SYSTEM: STRUCTURE, FUNCTION, AND PATHOLOGY

Christine Stadelmann et al.

PHYSIOLOGICAL REVIEWS (2019)

Add to Collection
Article Immunology

Physical Exercise Induces Immunoregulation of TREG, M2, and pDCs in a Lung Allergic Inflammation Model

Paula Fernandes et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection
Review Biotechnology & Applied Microbiology

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

Simon Faissner et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Add to Collection
Review Clinical Neurology

When encephalitogenic T cells collaborate with microglia in multiple sclerosis

Yifei Dong et al.

NATURE REVIEWS NEUROLOGY (2019)

Add to Collection
Article Neurosciences

Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination

Georgia Mandolesi et al.

NEUROBIOLOGY OF DISEASE (2019)

Add to Collection
Article Clinical Neurology

Exercise intensity-dependent immunomodulatory effects on encephalomyelitis

Nina Feinstein et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

Add to Collection
Article Cell Biology

The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis

Emanuele D'Amico et al.

CELLS (2019)

Add to Collection
Review Neurosciences

B cells in autoimmune and neurodegenerative central nervous system diseases

Joseph J. Sabatino et al.

NATURE REVIEWS NEUROSCIENCE (2019)

Add to Collection
Article Multidisciplinary Sciences

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Leslie Kirby et al.

NATURE COMMUNICATIONS (2019)

Add to Collection
Article Clinical Neurology

Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis - a community-based randomized controlled trial

Sebastian Proschinger et al.

BMC NEUROLOGY (2019)

Add to Collection
Review Immunology

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

Boris Reizis

IMMUNITY (2019)

Add to Collection
Article Anesthesiology

Voluntary wheel running reveals sex-specific nociceptive factors in murine experimental autoimmune encephalomyelitis

Katherine A. Mifflin et al.

PAIN (2019)

Add to Collection
Review Biochemistry & Molecular Biology

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Sofie Voet et al.

TRENDS IN MOLECULAR MEDICINE (2019)

Add to Collection
Review Clinical Neurology

The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis

Roberta Brambilla

ACTA NEUROPATHOLOGICA (2019)

Add to Collection
Article Medicine, Research & Experimental

Deficiency of Socs3 leads to brain-targeted experimental autoimmune encephalomyelitis via enhanced neutrophil activation and ROS production

Zhaoqi Yan et al.

JCI INSIGHT (2019)

Add to Collection
Review Clinical Neurology

Vascular pathology in multiple sclerosis: reframing pathogenesis around the blood-brain barrier

Jonathan I. Spencer et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)

Add to Collection
Article Neurosciences

CaMKIIα Mediates the Effect of IL-17 To Promote Ongoing Spontaneous and Evoked Pain in Multiple Sclerosis

Xiaoyu Hu et al.

JOURNAL OF NEUROSCIENCE (2018)

Add to Collection
Article Clinical Neurology

Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Tue Kjolhede et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Add to Collection
Article Clinical Neurology

High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial

Philipp Zimmer et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Add to Collection
Article Clinical Neurology

Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Tue Kjolhede et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Add to Collection
Article Clinical Neurology

High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial

Philipp Zimmer et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Add to Collection
Review Clinical Neurology

Functional morphology of the blood-brain barrier in health and disease

Stefan Liebner et al.

ACTA NEUROPATHOLOGICA (2018)

Add to Collection
Article Immunology

Physical activity and autoimmune diseases: Get moving and manage the disease

Kassem Sharif et al.

AUTOIMMUNITY REVIEWS (2018)

Add to Collection
Article Clinical Neurology

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+T lymphocytes and B cells

Joana Machado-Santos et al.

BRAIN (2018)

Add to Collection
Article Immunology

Dithiolethione ACDT suppresses neuroinflammation and ameliorates disease severity in experimental autoimmune encephalomyelitis

Ping-Chang Kuo et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

Add to Collection
Article Cell Biology

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

Francesca Cignarella et al.

CELL METABOLISM (2018)

Add to Collection
Article Immunology

The contribution of neutrophils to CNS autoimmunity

Emily R. Pierson et al.

CLINICAL IMMUNOLOGY (2018)

Add to Collection
Article Neurosciences

Exercise training attenuates experimental autoimmune encephalomyelitis by peripheral immunomodulation rather than direct neuroprotection

Ofira Einstein et al.

EXPERIMENTAL NEUROLOGY (2018)

Add to Collection
Review Immunology

Implications of macrophage polarization in autoimmunity

Samanta C. Funes et al.

IMMUNOLOGY (2018)

Add to Collection
Article Sport Sciences

Effects of Two Training Programs on Transcriptional Levels of Neurotrophins and Glial Cells Population in Hippocampus of Experimental Multiple Sclerosis

Maryam Naghibzadeh et al.

INTERNATIONAL JOURNAL OF SPORTS MEDICINE (2018)

Add to Collection
Review Medicine, General & Internal

Multiple sclerosis

Alan J. Thompson et al.

LANCET (2018)

Add to Collection
Review Immunology

Reassessing B cell contributions in multiple sclerosis

Rui Li et al.

NATURE IMMUNOLOGY (2018)

Add to Collection
Article Endocrinology & Metabolism

Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis

Motahare Mokhtarzade et al.

NEUROPEPTIDES (2018)

Add to Collection
Article Psychology, Biological

Acute aerobic exercise induces a preferential mobilisation of plasmacytoid dendritic cells into the peripheral blood in man

Frankie F. Brown et al.

PHYSIOLOGY & BEHAVIOR (2018)

Add to Collection
Article Medicine, Research & Experimental

Effector T Cells in Multiple Sclerosis

Belinda J. Kaskow et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

Add to Collection
Article Oncology

Association of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non-Small Cell Lung Cancer

Laura Mezquita et al.

JAMA ONCOLOGY (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis

Ivan Jelcic et al.

CELL (2018)

Add to Collection
Article Cell Biology

Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α

Samuel K. Jensen et al.

CELL REPORTS (2018)

Add to Collection
Article Medicine, Research & Experimental

CNS-resident classical DCs play a critical role in CNS autoimmune disease

David A. Giles et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Add to Collection
Article Immunology

Metabolic, Mental and Immunological Effects of Normoxic and Hypoxic Training in Multiple Sclerosis Patients: A Pilot Study

Anja Maehler et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection
Article Clinical Neurology

Regular Exercise Modifies Histopathological Outcomes of Pharmacological Treatment in Experimental Autoimmune Encephalomyelitis

Danielle Bernardes et al.

FRONTIERS IN NEUROLOGY (2018)

Add to Collection
Review Clinical Neurology

Multiple sclerosis: experimental models and reality

Hans Lassmann et al.

ACTA NEUROPATHOLOGICA (2017)

Add to Collection
Article Anatomy & Morphology

Physical exercise induces structural alterations in the hippocampal astrocytes: exploring the role of BDNF-TrkB signaling

Atoossa Fahimi et al.

BRAIN STRUCTURE & FUNCTION (2017)

Add to Collection
Article Neurosciences

Physical Exercise Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Peripheral Immune Response and Blood-Brain Barrier Disruption

Priscila S. Souza et al.

MOLECULAR NEUROBIOLOGY (2017)

Add to Collection
Review Clinical Neurology

Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

Tomas Olsson et al.

NATURE REVIEWS NEUROLOGY (2017)

Add to Collection
Article Immunology

Voluntary wheel running differentially affects disease outcomes in male and female mice with experimental autoimmune encephalomyelitis

Katherine A. Mifflin et al.

JOURNAL OF NEUROIMMUNOLOGY (2017)

Add to Collection
Article Medicine, General & Internal

Diagnosis of multiple sclerosis: progress and challenges

Wallace J. Brownlee et al.

LANCET (2017)

Add to Collection
Article Clinical Neurology

Exercise in patients with multiple sclerosis

Robert W. Motl et al.

LANCET NEUROLOGY (2017)

Add to Collection
Article Sport Sciences

Comparable Neutrophil Responses for Arm and Intensity-matched Leg Exercise

Christof A. Leicht et al.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2017)

Add to Collection
Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow et al.

NATURE (2017)

Add to Collection
Review Neurosciences

The role of peripheral immune cells in the CNS in steady state and disease

Marco Prinz et al.

NATURE NEUROSCIENCE (2017)

Add to Collection
Article Neurosciences

REGULAR EXERCISE PROMOTES MEMORY FUNCTION AND ENHANCES HIPPOCAMPAL NEUROPLASTICITY IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MICE

Tae-Woon Kim et al.

NEUROSCIENCE (2017)

Add to Collection
Article Multidisciplinary Sciences

Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination

Hedwich F. Kuipers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection
Article Multidisciplinary Sciences

Dendritic cell MST1 inhibits Th17 differentiation

Chunxiao Li et al.

NATURE COMMUNICATIONS (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Kv1.3 channel blocker (ImKTx88) maintains blood-brain barrier in experimental autoimmune encephalomyelitis

Jie Huang et al.

CELL AND BIOSCIENCE (2017)

Add to Collection
Article Immunology

Chemokine CCL17 is expressed by dendritic cells in the CNS during experimental autoimmune encephalomyelitis and promotes pathogenesis of disease

Christina Ruland et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

Add to Collection
Review Immunology

Spasticity in multiple sclerosis: Contribution of inflammation, autoimmune mediated neuronal damage and therapeutic interventions

Robert Patejdl et al.

AUTOIMMUNITY REVIEWS (2017)

Add to Collection
Article Clinical Neurology

Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis

Tobias Zrzavy et al.

BRAIN (2017)

Add to Collection
Review Immunology

Neutrophil perversion in demyelinating autoimmune diseases: Mechanisms to medicine

Courtney S. Casserly et al.

AUTOIMMUNITY REVIEWS (2017)

Add to Collection
Review Immunology

T cell responses in the central nervous system

Thomas Korn et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Prior regular exercise improves clinical outcome and reduces demyelination and axonal injury in experimental autoimmune encephalomyelitis

Danielle Bernardes et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Add to Collection
Article Clinical Neurology

Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica

Laura Hertwig et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection
Article Clinical Neurology

Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica

Laura Hertwig et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection
Article Immunology

Acute bouts of exercise induce a suppressive effect proliferation in human subjects: A meta-analysis

Jacob A. Siedlik et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

Add to Collection
Article Immunology

Habitual physical activity is associated with the maintenance of neutrophil migratory dynamics in healthy older adults

David B. Bartlett et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

Add to Collection
Article Immunology

Myeloid cell transmigration across the CNS vasculature triggers IL-1β-driven neuroinflammation during autoimmune encephalomyelitis in mice

Sebastien A. Levesque et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Add to Collection
Article Immunology

Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators

Helcio Alvarenga-Filho et al.

JOURNAL OF NEUROIMMUNOLOGY (2016)

Add to Collection
Article Neurosciences

Resveratrol defends blood-brain barrier integrity in experimental autoimmune encephalomyelitis mice

Dong Wang et al.

JOURNAL OF NEUROPHYSIOLOGY (2016)

Add to Collection
Article Cell Biology

12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis

Nathalie Deckx et al.

MEDIATORS OF INFLAMMATION (2016)

Add to Collection
Article Sport Sciences

Dendritic Cells Are Involved in the Effects of Exercise in a Model of Asthma

Breanne Mackenzie et al.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2016)

Add to Collection
Article Cell Biology

Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier

Hanna Gerwien et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Add to Collection
Review Immunology

Neutrophil migration in infection and wound repair: going forward in reverse

Sofia de Oliveira et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Add to Collection
Article Nutrition & Dietetics

Effect of moderate exercise on peritoneal neutrophils from juvenile rats

Glauber Ruda Braz et al.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2015)

Add to Collection
Article Biochemistry & Molecular Biology

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

Mauricio F. Farez et al.

CELL (2015)

Add to Collection
Article Neurosciences

Voluntary wheel running delays disease onset and reduces pain hypersensitivity in early experimental autoimmune encephalomyelitis (EAE)

Curtis Benson et al.

EXPERIMENTAL NEUROLOGY (2015)

Add to Collection
Article Immunology

Neutrophil-related factors as biomarkers in EAE and MS

Julie M. Rumble et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Add to Collection
Article Cell Biology

Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L-and MMP-9-Dependent Process in Multiple Sclerosis

Nathalie Deckx et al.

MEDIATORS OF INFLAMMATION (2015)

Add to Collection
Article Radiology, Nuclear Medicine & Medical Imaging

Multiple Sclerosis: Myeloperoxidase Immunoradiology Improves Detection of Acute and Chronic Disease in Experimental Model

Benjamin Pulli et al.

RADIOLOGY (2015)

Add to Collection
Article Neurosciences

Chronic Exercise Confers Neuroprotection in Experimental Autoimmune Encephalomyelitis

William M. Pryor et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2015)

Add to Collection
Article Gastroenterology & Hepatology

Exercise and the microbiota

Orla O'Sullivan et al.

GUT MICROBES (2015)

Add to Collection
Article Immunology

An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: Role of IL-8 and noradrenaline

M. E. Bote et al.

BRAIN BEHAVIOR AND IMMUNITY (2014)

Add to Collection
Article Immunology

Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response

Agnieszka Wlodarczyk et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Add to Collection
Article Clinical Neurology

Circulating dendritic cells of multiple sclerosis patients are proinflammatory and their frequency is correlated with MS-associated genetic risk factors

Kristof Thewissen et al.

MULTIPLE SCLEROSIS JOURNAL (2014)

Add to Collection
Article Biochemistry & Molecular Biology

Regulatory T cell proliferative potential is impaired in human autoimmune disease

Fortunata Carbone et al.

NATURE MEDICINE (2014)

Add to Collection
Article Neurosciences

Exercise protects against chronic restraint stress-induced oxidative stress in the cortex and hippocampus

Kim M. Gerecke et al.

BRAIN RESEARCH (2013)

Add to Collection
Article Medicine, Research & Experimental

IL-17A secretion by CD8(+) T cells supports Th17-mediated autoimmune encephalomyelitis

Magdalena Huber et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Add to Collection
Article Neurosciences

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

Veronique E. Miron et al.

NATURE NEUROSCIENCE (2013)

Add to Collection
Article Neurosciences

Axons are injured by antigen-specific CD8+ T cells through a MHC class I- and granzyme B-dependent mechanism

Brian M. Sauer et al.

NEUROBIOLOGY OF DISEASE (2013)

Add to Collection
Article Clinical Neurology

Physical Activity in Multiple Sclerosis: A Comparative Study of Vitamin D, Brain-Derived Neurotrophic Factor and Regulatory T Cell Populations

A. Waschbisch et al.

EUROPEAN NEUROLOGY (2012)

Add to Collection
Article Physiology

Exercise delays neutrophil apoptosis by a G-CSF-dependent mechanism

Frank C. Mooren et al.

JOURNAL OF APPLIED PHYSIOLOGY (2012)

Add to Collection
Article Immunology

Two discreet subsets of CD8 T cells modulate PLP91-110 induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice

Ashutosh K. Mangalam et al.

JOURNAL OF AUTOIMMUNITY (2012)

Add to Collection
Article Immunology

Neutrophils in multiple sclerosis are characterized by a primed phenotype

Matthias Naegele et al.

JOURNAL OF NEUROIMMUNOLOGY (2012)

Add to Collection
Article Medicine, Research & Experimental

Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice

Yun-Hee Sung et al.

LIFE SCIENCES (2012)

Add to Collection
Review Clinical Neurology

The benefits of exercise training in multiple sclerosis

Robert W. Motl et al.

NATURE REVIEWS NEUROLOGY (2012)

Add to Collection
Article Multidisciplinary Sciences

CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells

Karola Poppensieker et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection
Article Biochemistry & Molecular Biology

NO signaling in exercise training-induced anti-apoptotic effects in human neutrophils

Shu-Hui Su et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Add to Collection
Article Immunology

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

Aine C. Murphy et al.

BRAIN BEHAVIOR AND IMMUNITY (2010)

Add to Collection
Article Immunology

Combined exercise training reduces IFN-γ and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis

Zahra Golzari et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2010)

Add to Collection
Article Physiology

Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes

Shlomit Radom-Aizik et al.

JOURNAL OF APPLIED PHYSIOLOGY (2010)

Add to Collection
Article Immunology

Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis

Nathan R. York et al.

JOURNAL OF AUTOIMMUNITY (2010)

Add to Collection
Article Immunology

An Imbalance of Two Functionally and Phenotypically Different Subsets of Plasmacytoid Dendritic Cells Characterizes the Dysfunctional Immune Regulation in Multiple Sclerosis

Nicholas Schwab et al.

JOURNAL OF IMMUNOLOGY (2010)

Add to Collection
Review Multidisciplinary Sciences

Myelination and support of axonal integrity by glia

Klaus-Armin Nave

NATURE (2010)

Add to Collection
Article Neurosciences

CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis

LiPing Liu et al.

NATURE NEUROSCIENCE (2010)

Add to Collection
Review Clinical Neurology

Targeting dendritic cells to treat multiple sclerosis

Manuel Comabella et al.

NATURE REVIEWS NEUROLOGY (2010)

Add to Collection
Article Immunology

Dysfunction of IL-10-producing type 1 regulatory T cells and CD4+CD25+ regulatory T cells in a mimic model of human multiple sclerosis in Cynomolgus monkeys

Anlun Ma et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2009)

Add to Collection
Article Sport Sciences

Antioxidant regulatory mechanisms in neutrophils and lymphocytes after intense exercise

Miguel D. Ferrer et al.

JOURNAL OF SPORTS SCIENCES (2009)

Add to Collection
Article Immunology

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

Juan M. Ilarregui et al.

NATURE IMMUNOLOGY (2009)

Add to Collection
Article Neurosciences

Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis

Silvia Rossi et al.

NEUROBIOLOGY OF DISEASE (2009)

Add to Collection
Article Physiology

Effects of 30 min of aerobic exercise on gene expression in human neutrophils

Shlomit Radom-Aizik et al.

JOURNAL OF APPLIED PHYSIOLOGY (2008)

Add to Collection
Article Immunology

Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes

Amit Saxena et al.

JOURNAL OF IMMUNOLOGY (2008)

Add to Collection
Article Biochemistry & Molecular Biology

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Hania Kebir et al.

NATURE MEDICINE (2007)

Add to Collection
Article Sport Sciences

Modulation of dendritic cells by endurance training

L.-M. Chiang et al.

INTERNATIONAL JOURNAL OF SPORTS MEDICINE (2007)

Add to Collection
Article Sport Sciences

Oat β-glucan effects on neutrophil respiratory burst activity following exercise

E. Angela Murphy et al.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2007)

Add to Collection
Article Biochemistry & Molecular Biology

Intense physical activity enhances neutrophil antioxidant enzyme gene expression. Immunocytochemistry evidence for catalase secretion

Antoni Sureda et al.

FREE RADICAL RESEARCH (2007)

Add to Collection
Article Sport Sciences

Gender differences in macrophage antiviral function following exercise stress

Adrienne S. Brown et al.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2006)

Add to Collection
Article Clinical Neurology

Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis

M Stasiolek et al.

BRAIN (2006)

Add to Collection
Article Physiology

Intracellular mechanisms responsible for exercise-induced suppression of macrophage antigen presentation

MA Ceddia et al.

JOURNAL OF APPLIED PHYSIOLOGY (2000)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.