Journal
EXPERT REVIEW OF NEUROTHERAPEUTICS
Volume 16, Issue 8, Pages 951-960Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14737175.2016.1193008
Keywords
Multiple sclerosis; exercise; disease progression; relapse; disability
Categories
Funding
- Acorda Therapeutics
- Biogen Idec
- Sun Health Technologies
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Introduction: There is consensus that exercise represents a behavioral approach for the restoration of function and management of symptoms among persons with multiple sclerosis (MS). The current paper provides a review on the topic of exercise and physical activity as MS-disease modifying treatments.Areas covered: Firstly, metrics for evaluating disease modification and progression in MS are described. Secondly, evidence for exercise as a MS-disease modifying therapy based on individual studies, literature reviews, and meta-analyses is summarized. Finally, the paper focuses on major limitations of the existing body of research.Expert commentary: Exercise and physical activity have been associated with reduced relapse rate, mobility disability and its progression, and lesion volume, and improved neuroperformance, particularly walking outcomes. This evidence provides a positive, yet preliminary, picture for exercise having possible effects on markers of disease modification and progression in MS.
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