BRAF V600E mutation in papillary thyroid microcarcinoma: is it a predictor for the prognosis of patients with intermediate to high recurrence risk?

Objective The BRAF(V600E) mutation is the universal genetic mutation in papillary thyroid microcarcinoma (PTMC). The present study is to estimate the role of the BRAFV600E mutation in the clinical outcome of PTMC with intermediate to high recurrence risk after radioactive iodine (RAI) therapy, which is considered to be an indolent tumor.Methods We conducted a single-center retrospective study. Between May 2016 and March 2019, PTMC patients with known BRAF(V600E) status who received RAI therapy were reviewed at the Second Hospital of Shandong University. Treatment and follow-up were defined according to criteria used in the 2015 ATA guidelines. The association between the BRAF(V600E) mutation and clinicopathological characteristics, response to RAI therapy, and recurrence after a period of follow-up were analyzed. Propensity score matching (PSM) and logistic regression were used to control confounding variables.Results Of the 322 patients with intermediate to high recurrence risk in PTMC, the mean age of the patients were 43.7 +/- 12.2 years, and 72.1% were women. BRAF(V600E )mutation was found in 64.9% (209/322). After PSM, 112 pairs of patients were matched, and except for multifocality (P = 0.001), extrathyroidal invasion (P = 0.003) and tumor size (P = 0.03), there was no significant difference in all baseline characteristics between the two groups. An excellent response (ER) to RAI therapy was observed in 273 patients (84.7%). At the end of the study, 17(5.2%) and 6(1.8%) patients showed structural incomplete response (SIR) and biochemical incomplete response (BIR) status. The proportion of patients who achieved ER status in the BRAF(V600E) mutation positive and negative groups was 86.6% and 81.4%, respectively. Kaplan-Meier analyses showed that the BRAF(V600E )mutation was not related to lower ER reached time. The median follow-up was 51 months.Conclusions We found the BRAF(V600E) mutation was associated with multifocality, extrathyroidal invasion, and tumor size in papillary thyroid microcarcinoma. However, the BRAF(V600E )mutation had no significant association with clinical outcomes in patients with intermediate to high recurrence risk after RAI therapy. Furthermore, the extra-thyroid uptake results and distant metastasis had been proven to be independent factor predicting the clinical response.Registration numberChiCTR2200062911

Automated summary

This study evaluated the role of the BRAFV600E mutation in the clinical outcomes of PTMC after RAI therapy. The BRAFV600E mutation was found to be associated with multifocality, extrathyroidal invasion, and tumor size in PTMC, but had no significant association with clinical outcomes in patients with intermediate to high recurrence risk.