One-pot furan synthesis through diethylzinc-mediated coupling reaction between two α-bromocarbonyl compounds

Polysubstituted furans were synthesized in one-pot through the Et2Zn-mediated coupling reaction between dibromoketones and monobromo carbonyl compounds and the subsequent beta-elimination with bromoacetyl bromide. Polysubstituted pyrroles were also prepared in one-pot by addition of primary amines after the coupling reaction.

Automated summary

Polysubstituted furans and pyrroles were synthesized in one-pot through coupling reactions and subsequent elimination reactions.