☆ 4.4 Article

Semisynthetic polymyxins with potent antibacterial activity and reduced kidney cell toxicity

RSC MEDICINAL CHEMISTRY (2023)

Related references

Note: Only part of the references are listed.

Article Medicine, General & Internal

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

Add to Collection

Review Microbiology

Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020

Neha K. Prasad et al.

Summary: The World Health Organization warns that our current arsenal of antibiotics is not innovative enough to combat multidrug-resistant Gram-negative pathogens. The lack of new antibiotics with novel mechanisms of action against these bacteria is concerning, with the last FDA-approved drug discovered nearly 60 years ago. A significant portion of antibiotic candidates initiated in the 2000s were discontinued, indicating a failure to translate scientific innovations into clinically beneficial treatments. This review aims to analyze the reasons for failure in clinical development of Gram-negative antibiotics to guide more successful future strategies.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

Add to Collection

Article Multidisciplinary Sciences

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

Kade D. Roberts et al.

Summary: The emergence of multidrug-resistant Gram-negative pathogens poses a global medical challenge. Polymyxin antibiotics are often the last therapeutic option against these pathogens, but they have limitations in safety and efficacy. This study reports the discovery and development of a synthetic lipopeptide that shows improved safety and efficacy against top-priority multidrug-resistant Gram-negative pathogens.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Chemistry, Medicinal

Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids

Cornelis J. Slingerland et al.

Summary: Polymyxins are potent and specific anti-infective agents against Gram-negative bacteria. The synthesis and evaluation of novel polymyxin analogues with reduced nephrotoxic effects were described in this study.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection

Article Chemistry, Medicinal

Polymyxin Stereochemistry and Its Role in Antibacterial Activity and Outer Membrane Disruption

Cornelis J. Slingerland et al.

Summary: With increasing antibiotic resistance, there is renewed interest in polymyxins, a type of lipopeptide antibiotics with potent anti-Gram-negative activity. This study synthesized the full enantiomers of polymyxin B and the polymyxin B nonapeptide (PMBN) to investigate their mechanism of action. The enantiomeric species showed reduced antibacterial activity, lower LPS binding, lower outer membrane permeabilization, and loss of synergetic potential, providing new insights into the stereochemical requirements of polymyxin B and PMBN.

ACS INFECTIOUS DISEASES (2022)

Add to Collection

Review Chemistry, Medicinal

Synergy by Perturbing the Gram-Negative Outer Membrane: Opening the Door for Gram-Positive Specific Antibiotics

Charlotte M. J. Wesseling et al.

Summary: New approaches targeting Gram-negative bacteria are crucial in combating antibiotic resistance. This review focuses on peptide-based and small organic compounds that disrupt the outer membrane of Gram-negative bacteria and synergize with clinically used antibiotics. The review also assesses the hemolytic activity of these compounds and their selectivity towards Gram-negative bacteria.

ACS INFECTIOUS DISEASES (2022)

Add to Collection

Article Infectious Diseases

Acute toxicity is a dose-limiting factor for intravenous polymyxin B: A safety and pharmacokinetic study in healthy Chinese subjects

Xiaofen Liu et al.

Summary: The study investigated the safety and pharmacokinetics of polymyxin B in healthy subjects, highlighting acute toxicity as a dose-limiting factor for intravenous polymyxin B administration.

JOURNAL OF INFECTION (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria

Kristen A. Munoz et al.

Summary: It has been over 50 years since the FDA approved a new class of antibiotics targeting problematic Gram-negative bacteria, with the main challenge being the inability of most small molecules to penetrate the gram-negative membrane and accumulate in the cell. A successful strategy has been developed to enhance the accumulation of Gram-positive antibiotics, resulting in broad-spectrum activity.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

Add to Collection

Review Pharmacology & Pharmacy

Are outer-membrane targets the solution for MDR Gram-negative bacteria?

Scott S. Walker et al.

Summary: The outer membrane of Gram-negative bacteria poses a significant barrier to antibacterial agents, containing proteins that could potentially serve as targets for new therapies.

DRUG DISCOVERY TODAY (2021)

Add to Collection

Article Chemistry, Medicinal

Potentiation of Antibiotics against Gram-Negative Bacteria by Polymyxin B Analogue SPR741 from Unique Perturbation of the Outer Membrane

Shawn French et al.

ACS INFECTIOUS DISEASES (2020)

Add to Collection

Editorial Material Microbiology

Antibiotic development - economic, regulatory and societal challenges

Christine Ardal et al.

NATURE REVIEWS MICROBIOLOGY (2020)

Add to Collection

Article Chemistry, Medicinal

Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206

Pamela Brown et al.

ACS INFECTIOUS DISEASES (2019)

Add to Collection

Article Infectious Diseases

Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli

Martti Vaara et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

Add to Collection

Article Multidisciplinary Sciences

Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics

Craig R. MacNair et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Review Biotechnology & Applied Microbiology

Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections

Pamela Brown et al.

JOURNAL OF ANTIBIOTICS (2017)

Add to Collection

Review Pharmacology & Pharmacy

The safety of polymyxin antibiotics

Theodoros Kelesidis et al.

EXPERT OPINION ON DRUG SAFETY (2015)

Add to Collection

Article Chemistry, Organic

Syntheses of Dap-3 Polymyxin Analogues via a Tris-Boc-Protected Polymyxin B Heptapeptide

Bryan Li et al.

SYNTHESIS-STUTTGART (2015)

Add to Collection

Article Toxicology

Early Prediction of Polymyxin-Induced Nephrotoxicity With Next-Generation Urinary Kidney Injury Biomarkers

Natalie D. Keirstead et al.

TOXICOLOGICAL SCIENCES (2014)

Add to Collection

Article Chemistry, Medicinal

Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections

Thomas V. Magee et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Add to Collection

Review Biotechnology & Applied Microbiology

Platforms for antibiotic discovery

Kim Lewis

NATURE REVIEWS DRUG DISCOVERY (2013)

Add to Collection

Article Infectious Diseases

Activity of Polymyxin B and the Novel Polymyxin Analogue CB-182,804 Against Contemporary Gram-Negative Pathogens in New York City

John Quale et al.

MICROBIAL DRUG RESISTANCE (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells

Marie-Paule Mingeot-Leclercq et al.

PEPTIDES (2012)

Add to Collection

Article Cell Biology

Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters

Martijn J. Wilmer et al.

CELL AND TISSUE RESEARCH (2010)

Add to Collection

Article Infectious Diseases

Polymyxin B and colistimethate are comparable as to efficacy and renal toxicity

Maura S. Oliveira et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2009)

Add to Collection

Review Pharmacology & Pharmacy

Role of glutathione transport processes in kidney function

LH Lash

TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)

Add to Collection

Article Biophysics

Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide

K Brandenburg et al.

BIOPHYSICAL JOURNAL (2005)

Add to Collection

Article Chemistry, Multidisciplinary

Synthesis of lipid A derivatives and their interactions with polymyxin B and polymyxin B nonapeptide

N Yin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.