Journal
ELIFE
Volume 5, Issue -, Pages -Publisher
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/elife.14315
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Funding
- European Regional Development Fund [CEITEC CZ.1.05/1.1.00/02.0068]
- International Headache Society
- Turkiye Bilimsel ve Teknolojik Arastirma Kurumu
- John Carroll University, Department of Physics
- Deutsche Forschungsgemeinschaft [DFG TH 2031/1]
- Natural Sciences and Engineering Research Council of Canada
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung
- National Institutes of Health [N5082097, EB003832, EB00790, S10RR029050, N5057198, U01NS094232]
- Norges Forskningsrad
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Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.
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