4.8 Article

Immediate perception of a reward is distinct from the reward's long-term salience

Journal

ELIFE
Volume 5, Issue -, Pages -

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ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.22283

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  1. Stowers Institute for Medical Research

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Reward perception guides all aspects of animal behavior. However, the relationship between the perceived value of a reward, the latent value of a reward, and the behavioral response remains unclear. Here we report that, given a choice between two sweet and chemically similar sugarsL- and D-arabinoseDrosophila melanogaster prefers D- over L- arabinose, but forms long-term memories of L-arabinose more reliably. Behavioral assays indicate that L-arabinose-generated memories require sugar receptor Gr43a, and calcium imaging and electrophysiological recordings indicate that L- and D-arabinose differentially activate Gr43a-expressing neurons. We posit that the immediate valence of a reward is not always predictive of the long-term reinforcement value of that reward, and that a subset of sugar-sensing neurons may generate distinct representations of similar sugars, allowing for rapid assessment of the salient features of various sugar rewards and generation of reward-specific behaviors. However, how sensory neurons communicate information about L-arabinose quality and concentrationfeatures relevant for long-term memoryremains unknown.

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